DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and ZNF662

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001128128.1	Gene:	ZNF662 / 389114	HGNCID:	31930	Length:	452	Species:	Homo sapiens

Alignment Length:	499	Identity:	132/499 - (26%)
Similarity:	193/499 - (38%)	Gaps:	150/499 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 GLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQ 306
            |||       |:|:|.|.:     :|.|....|.        |.|..|.|       ||:..:..
Human    13 GLV-------LELLPGQPA-----LPRARRESVT--------FEDVAVYF-------SENEWIGL 50

  Fly   307 SPMTQVPSNRADFNELLLD-----------------------GEM--------LIDNDPAFATSN 340
            .     |:.||.:.:::|:                       ||.        .:|.:.....|:
Human    51 G-----PAQRALYRDVMLENYGAVASLAFPFPKPALISQLERGETPWCSVPRGALDGEAPRGISS 110

  Fly   341 QNTNPPKKEMF-----------SSLILGSVLQ-CEFCEYIFADIAE---LLVHSASHVAERRFEC 390
            :.....|||.|           ..::|.|..| |...|..|....|   .|.....::...|.|.
Human   111 EGVLKRKKEDFILKEEIIEEAQDLMVLSSGPQWCGSQELWFGKTCEEKSRLGRWPGYLNGGRMES 175

  Fly   391 TACDI-------QMNTAKEAS----------IHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKF 438
            :..||       :|.:.:|:|          ||.:    .:.|.|         :::|..|...|
Human   176 STNDIIEVIVKDEMISVEESSGNTDVNNLLGIHHK----ILNEQI---------FYICEECGKCF 227

  Fly   439 ANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKRE------ 497
            ...:...:|:.|         .||:| :..|..|...|.|....:|| :..|...|..|
Human   228 DQNEDFDQHQKT---------HNGEK-VYGCKECGKAFSFRSHCIAH-QRIHSGVKPYECQECAK 281

  Fly   498 ----------KETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTI 552
                      .:..:||.   :.:.|..|||.::|::.|.||.|.|.|.||:.|:|  |.:.||.
Human   282 AFVWKSNLIRHQRIHTGE---KPFECKECGKGFSQNTSLTQHQRIHTGEKPYTCKE--CGKSFTR 341

  Fly   553 RPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQ 617
            .|.|..| ::.||||:||.|..|||.|:..|...||:.:|.|::.:||.:|||.|:....|..||
Human   342 NPALLRH-QRMHTGEKPYECKDCGKGFMWNSDLSQHQRVHTGDKPHECTDCGKSFFCKAHLIRHQ 405

  Fly   618 RIHTGEKPYSCLFCTKTFRQ---------RGDRDKHIRARHSHL 652
            ||||||:||.|..|.|.|.|         |..|||....:.|||
Human   406 RIHTGERPYKCNDCGKAFSQNSVLIKHQRRHARDKPYNCQISHL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	3/7 (43%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	78/221 (35%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	21/50 (42%)
		C2H2 Zn finger	541..561	CDD:275368	8/19 (42%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..609	CDD:290200	10/23 (43%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	9/26 (35%)
ZNF662	NP_001128128.1	KRAB	33..92	CDD:214630	13/78 (17%)
		KRAB	33..72	CDD:279668	11/58 (19%)
		C2H2 Zn finger	220..240	CDD:275368	5/28 (18%)
		C2H2 Zn finger	248..268	CDD:275368	6/20 (30%)
		zf-H2C2_2	264..284	CDD:290200	4/20 (20%)
		COG5048	<272..427	CDD:227381	63/160 (39%)
		C2H2 Zn finger	276..296	CDD:275368	0/19 (0%)
		zf-H2C2_2	288..313	CDD:290200	6/27 (22%)
		C2H2 Zn finger	304..324	CDD:275368	9/19 (47%)
		zf-H2C2_2	316..341	CDD:290200	12/26 (46%)
		C2H2 Zn finger	332..352	CDD:275368	8/22 (36%)
		zf-H2C2_2	344..367	CDD:290200	12/23 (52%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		zf-H2C2_2	372..395	CDD:290200	9/22 (41%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		zf-H2C2_2	400..425	CDD:290200	15/24 (63%)
		C2H2 Zn finger	416..436	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910