DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and ZNF749

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001018855.2	Gene:	ZNF749 / 388567	HGNCID:	32783	Length:	778	Species:	Homo sapiens

Alignment Length:	610	Identity:	144/610 - (23%)
Similarity:	218/610 - (35%)	Gaps:	187/610 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 AFKQILQEADGKKGF-------DPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRI 137
            |...:||:.....|:       |.:|.|.:..||.:.........:..:|...::::........
Human   163 ASSDLLQQQVLNSGWKLYRDTQDGEAFQGEQNDFNSSQGGKDFCHQHGLFEHQKTHNGERPYEFS 227

  Fly   138 KC------PTCLVQFDAVAFQNHSCEAKPIEVA-----------VPQQEKPHLVPTVSAPPAPLS 185
            :|      .:.|:::.    |||:.| :|.|..           :.|.:|.|....:|....|:
Human   228 ECGELFRYNSNLIKYQ----QNHAGE-RPYEGTEYGKTFIRKSNLVQHQKIHSEGFLSKRSDPI- 286

  Fly   186 KPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKH 250
                     |:|..|.|                      ..|.|||.|.:.|:..:.||.|.:.|
Human   287 ---------EHQEILSR----------------------PTPYECTQCGKAFLTQAHLVGHQKTH 320

  Fly   251 ALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSN 315
                    |.|||:           :||.||:.|.......||..:|..|              .
Human   321 --------TGEQPY-----------ECNKCGKFFMYNSKLIRHQKVHTGE--------------R 352

  Fly   316 RADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSA 380
            |.:.:|.   |::.:|   :|...........:..|         :|..|...|:..:.|.:|..
Human   353 RYECSEC---GKLFMD---SFTLGRHQRVHTGERPF---------ECSICGKFFSHRSTLNMHQR 402

  Fly   381 SHVAERRFECTAC----DIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANT 441
            .|..:|.::|:.|    .::.|..:...||                 |..|.:.|..||..|...
Human   403 VHAGKRLYKCSECGKAFSLKHNVVQHLKIH-----------------TGERPYECTECEKAFVRK 450

  Fly   442 DLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAG 506
            ..|.:|:        :::.:.             |....|.:.|   |.::.
Human   451 SHLVQHQ--------KIHTDA-------------FSKRSDLIQH---KRIDI------------- 478

  Fly   507 RIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTG----- 566
            |.|.|.|..|||::...:||..|.:.|.|.:|:.|.:  |.:.|..:..|..| .|.||.
Human   479 RPRPYTCSECGKAFLTQAHLVGHQKIHTGERPYECTQ--CAKAFVRKSHLVQH-EKIHTDAFSKR 540

  Fly   567 ------------ERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRI 619
                        .|||:|..|||.|||.:....|:.|..|||||||.||||.|..:..|..||||
Human   541 SDLIQHKRIDLRPRPYVCSECGKAFLTQAHLDGHQKIQTGERRYECNECGKFFLDSYKLVIHQRI 605

  Fly   620 HTGEKPYSCLFCTKTFRQRGDRDKH 644
            |||||||.|..|.|.||.|....:|
Human   606 HTGEKPYKCSKCGKFFRYRCTLSRH 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	68/212 (32%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	16/50 (32%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..581	CDD:290200	13/42 (31%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..609	CDD:290200	14/23 (61%)
		zf-C2H2	598..620	CDD:278523	12/21 (57%)
		C2H2 Zn finger	600..620	CDD:275368	10/19 (53%)
		zf-H2C2_2	612..637	CDD:290200	16/24 (67%)
		C2H2 Zn finger	628..646	CDD:275368	7/17 (41%)
ZNF749	NP_001018855.2	KRAB	8..62	CDD:214630
		KRAB	10..47	CDD:279668
		C2H2 Zn finger	202..218	CDD:275368	1/15 (7%)
		C2H2 Zn finger	226..246	CDD:275368	3/23 (13%)
		C2H2 Zn finger	258..274	CDD:275368	2/15 (13%)
		COG5048	295..689	CDD:227381	117/441 (27%)
		C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		C2H2 Zn finger	328..348	CDD:275368	7/19 (37%)
		C2H2 Zn finger	356..376	CDD:275368	4/25 (16%)
		zf-H2C2_2	371..393	CDD:290200	4/30 (13%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		C2H2 Zn finger	412..432	CDD:275368	3/19 (16%)
		zf-H2C2_2	424..449	CDD:290200	9/41 (22%)
		C2H2 Zn finger	440..460	CDD:275368	6/27 (22%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		C2H2 Zn finger	513..533	CDD:275368	6/22 (27%)
		C2H2 Zn finger	558..578	CDD:275368	8/19 (42%)
		C2H2 Zn finger	586..606	CDD:275368	10/19 (53%)
		zf-H2C2_2	599..623	CDD:290200	16/23 (70%)
		C2H2 Zn finger	614..634	CDD:275368	7/17 (41%)
		zf-H2C2_2	627..649	CDD:290200	1/4 (25%)
		C2H2 Zn finger	642..662	CDD:275368
		C2H2 Zn finger	670..689	CDD:275368
		C2H2 Zn finger	698..718	CDD:275368
		C2H2 Zn finger	727..745	CDD:275368
		C2H2 Zn finger	753..773	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910