DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment topi and ZNF808

DIOPT Version :10

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_001034975.2 Gene:ZNF808 / 388558 HGNCID:33230 Length:903 Species:Homo sapiens


Alignment Length:741 Identity:173/741 - (23%)
Similarity:271/741 - (36%) Gaps:235/741 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 VLATNES------TGGLERIVSHEELSRFFAVGPAGALPMPTDVVVERTLADPAFKQILQE---- 87
            ||:|.:.      ||.|:|..|:.                         :.|..|::|.:|    
Human    74 VLSTGQGNREVIHTGTLQRHQSYH-------------------------IGDFCFQEIEKEIHNI 113

  Fly    88 -----ADGKKGFDPQAEQMK------------------IRDFLAGVTSSKMTTEQSVFH--GSRS 127
                 .|.:.|.:....::|                  |:|.|.....|.: .|..:|.  |..:
Human   114 EFQCQEDERNGHEAPTTKIKKLTGSTDQHDHRHAGNKPIKDQLGSSFYSHL-PELHIFQIKGEIA 177

  Fly   128 N---------SSASTVNRIKC-PTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPA 182
            |         ||.||..||.| |...:..:   :.|:...:.    .:||:::.|:        .
Human   178 NQLEKSTSDASSVSTSQRISCRPQIHISNN---YGNNPLNSS----LLPQKQEVHM--------R 227

  Fly   183 PLSKPASE--------RVIRENQVRLRRYIKD-EMKYDLATGIESSRK--------NAAKGPNEC 230
            ..|.|.:|        .::|::|:   .::.| :.|.|:...:.:.::        :..:.|.:|
Human   228 EKSFPCNESGKAFNCSSLLRKHQI---PHLGDKQYKCDVCGKLFNHKQYLACHRRCHTGEKPYKC 289

  Fly   231 TMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGL 295
            ..|.:.|.:.|.|..|...|        |..:|:           |||.||::|........|..
Human   290 KECGKSFSYKSSLTCHHRLH--------TGVKPY-----------KCNECGKVFRQNSALVIHKA 335

  Fly   296 IHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVL 360
            ||..|      .|.......:| ||:            .:..:.:|..:...|.          .
Human   336 IHTGE------KPYKCNECGKA-FNQ------------QSHLSRHQRLHTGVKP----------Y 371

  Fly   361 QCEFCEYIFADIAELLVHSASHVAERRFECTAC----DIQMNTAKEASIHF--------QTDCIF 413
            :|:.||..||..:.|..|:..|..|:.::|..|    :.|.:.|:...:|.        :.|.:|
Human   372 KCKICEKAFACHSYLANHTRIHSGEKTYKCNECGKAFNHQSSLARHHILHTGEKPYKCEECDKVF 436

  Fly   414 MREAIRSLNVTLSRY---------FVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPC 469
            .:::      ||.|:         :.|.||:..|.....|..||        |:: .|:| ...|
Human   437 SQKS------TLERHKRIHTGEKPYKCKVCDTAFTCNSQLARHR--------RIH-TGEK-TYKC 485

  Fly   470 DFCDVNFEFAHDFLA----HSEEK-------------------HLNKKKREKETRNTGAGRI--- 508
            :.|...|......|.    ||.||                   |......||..:.|...::   
Human   486 NECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASLVYHRRLHTLEKSYKCTVCNKVFMR 550

  Fly   509 --------------RQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDH 559
                          :.|.|:.|||::.|.|||.:|.|.|.|.||:.|  |.||:.|..:..|..|
Human   551 NSVLAVHTRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKC--EACDKVFGQKSALESH 613

  Fly   560 IRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEK 624
             ::.||||:||.|.||...|...|...:|..||.||:.|:|.||||.|....:|..|:|:|.|||
Human   614 -KRIHTGEKPYRCQVCDTAFTWNSQLARHTRIHTGEKTYKCNECGKTFSYKSSLVWHRRLHGGEK 677

  Fly   625 PYSCLFCTKTFRQRGDRDKHIRARHS 650
            .|.|..|.|.|..|....||.|. ||
Human   678 SYKCKVCDKAFVCRSYVAKHTRI-HS 702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275370 6/19 (32%)
C2H2 Zn finger 277..297 CDD:275370 6/19 (32%)
C2H2 Zn finger 431..453 CDD:275368 7/21 (33%)
COG5048 <450..647 CDD:227381 75/236 (32%)
C2H2 Zn finger 469..490 CDD:275368 8/43 (19%)
C2H2 Zn finger 513..564 CDD:275368 21/50 (42%)
C2H2 Zn finger 541..561 CDD:275368 7/19 (37%)
C2H2 Zn finger 572..592 CDD:275368 6/19 (32%)
C2H2 Zn finger 600..620 CDD:275368 9/19 (47%)
zf-H2C2_2 612..637 CDD:463886 12/24 (50%)
C2H2 Zn finger 628..646 CDD:275368 7/17 (41%)
ZNF808NP_001034975.2 KRAB 24..60 CDD:460171
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..154 3/32 (9%)
COG5048 206..585 CDD:227381 88/460 (19%)
C2H2 Zn finger 233..253 CDD:275368 3/22 (14%)
C2H2 Zn finger 261..281 CDD:275368 1/19 (5%)
C2H2 Zn finger 289..309 CDD:275368 6/19 (32%)
C2H2 Zn finger 317..337 CDD:275368 6/19 (32%)
C2H2 Zn finger 345..365 CDD:275368 4/32 (13%)
C2H2 Zn finger 373..393 CDD:275368 7/19 (37%)
COG5048 397..839 CDD:227381 95/326 (29%)
C2H2 Zn finger 401..421 CDD:275368 4/19 (21%)
C2H2 Zn finger 429..449 CDD:275368 5/25 (20%)
C2H2 Zn finger 457..477 CDD:275368 8/27 (30%)
C2H2 Zn finger 485..505 CDD:275368 4/19 (21%)
C2H2 Zn finger 513..533 CDD:275368 1/19 (5%)
C2H2 Zn finger 541..561 CDD:275368 1/19 (5%)
C2H2 Zn finger 569..589 CDD:275368 10/19 (53%)
C2H2 Zn finger 597..617 CDD:275368 7/22 (32%)
C2H2 Zn finger 625..645 CDD:275368 6/19 (32%)
C2H2 Zn finger 653..673 CDD:275368 9/19 (47%)
C2H2 Zn finger 681..701 CDD:275368 8/20 (40%)
C2H2 Zn finger 709..729 CDD:275368
C2H2 Zn finger 737..757 CDD:275368
C2H2 Zn finger 765..785 CDD:275368
C2H2 Zn finger 793..813 CDD:275368
C2H2 Zn finger 821..841 CDD:275368
zf-H2C2_2 833..858 CDD:463886
C2H2 Zn finger 849..869 CDD:275368
zf-H2C2_2 861..885 CDD:463886
C2H2 Zn finger 877..897 CDD:275368
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.