DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and CG7386

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	713	Identity:	131/713 - (18%)
Similarity:	203/713 - (28%)	Gaps:	297/713 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 CPTCLVQFDAVAFQNHSCEAKPI----EVAVPQQEKP-----HLVPTVSAPPAPLSKPAS----- 189
            |..|..:.:.:......| |:.|    |:...|:..|     .:.....||..| .:|||
  Fly    55 CTQCFTKLNDLHDFRELC-AESIKRLKEMMTSQRNMPMGVFESIADDSEAPERP-EEPASFDPLL 117

  Fly   190 ----ERVIRENQV---------RLRRYIKDEMKYDLAT----GIESSRKNA---------AKGPN 228
                |.:..|..|         .|..:.:|:.:...::    |:|..:|.:         |.|..
  Fly   118 NNKLEMIDNEEDVFKLLEKVDKELEEHSRDQSEEHFSSAEHNGLEEEKKESEGFNSDDEQAMGQR 182

  Fly   229 -------------ECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQP-----HTIPAAGLHV-- 273
                         .|::|.:||...|....|| ||..||:|.|..|:.     .|..|..|||
  Fly   183 RIANDKRKLFRLMSCSICQQKFKKQSKFEEHM-KHHNDLLPFQCQEESCRKGFTTAGALRLHVDY 246

  Fly   274 --------------------------------------VV------KCNSCGRIFYDPQVAFRHG 294
                                                  |:      .|..||.:|..|....:|.
  Fly   247 AHSKKEDTVPCTVEGCQLVFSRLRLLTIHLKKVHNQARVIAPRGEQSCKECGVVFRCPVAMKKHM 311

  Fly   295 LIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSV 359
            ..|..|          ::|
  Fly   312 YTHTGE----------ELP---------------------------------------------- 320

  Fly   360 LQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVT 424
            ..|..|...|...:.|..|...|...:.:.|..|.::..|.:|.|.|.             |..|
  Fly   321 YPCTICGKGFYINSALKNHLLRHAGIKNYVCQYCGVRKTTRQEWSKHI-------------LIHT 372

  Fly   425 LSRYFVCNVCELKFANTDLLQEH------RCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFL 483
            ....|.|.:|:.......:|:.|      :..:|               .|.:|...|..|:...
  Fly   373 QRNQFKCRICDYATHTKRVLESHVKIVHEKIRNF---------------ACQYCGKTFGKAYACK 422

  Fly   484 AHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQ-------------- 534
            .| |..|..:|:.|               |.:|.|.:..|..|..||:.|:
  Fly   423 IH-EMAHTGEKRCE---------------CKVCDKKFLHSESLNNHLKIHEKSVERALETYKQVQ 471

  Fly   535 --------------------------------------------GVKP-----FVCQE-----EN 545
                                                        .|.|     ||.:|     .:
  Fly   472 VNGDASDTQVDSHQLLKVYAESVASIPKNPRRVEQVDVALLAGTAVNPTDEIQFVQKEGMYLCPS 536

  Fly   546 CDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRA 610
            |.:.|....::..|.:..|...:.:.|..|.:||.......||..||.||:.:||:.||.||.:.
  Fly   537 CSQGFKSIGNMKRHYKSVHEKVKDFECRFCSRRFANSQSVKQHEWIHTGEKPFECKTCGNRFRQV 601

  Fly   611 DALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHL---------DANSRLMMQMQK 664
            .||..||::| .|||      .|...:|.||.:.:.|....:         |..::|.::.|:
  Fly   602 AALIRHQKVH-DEKP------AKPLGERNDRKQKVEALRQEIAKVAKKELKDLKNQLALEKQQ 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..453	CDD:275368	4/27 (15%)
		COG5048	<450..647	CDD:227381	55/264 (21%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	16/118 (14%)
		C2H2 Zn finger	541..561	CDD:275368	4/24 (17%)
		zf-H2C2_2	555..581	CDD:290200	6/25 (24%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	12/23 (52%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	9/24 (38%)
		C2H2 Zn finger	628..646	CDD:275368	4/17 (24%)
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	5/26 (19%)
		C2H2 Zn finger	197..217	CDD:275368	8/20 (40%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		C2H2 Zn finger	323..343	CDD:275368	5/19 (26%)
		C2H2 Zn finger	351..371	CDD:275368	7/32 (22%)
		C2H2 Zn finger	379..400	CDD:275368	4/20 (20%)
		C2H2 Zn finger	408..428	CDD:275368	6/20 (30%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	534..555	CDD:275368	3/20 (15%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		zf-H2C2_2	575..600	CDD:290200	12/24 (50%)
		C2H2 Zn finger	591..611	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840