DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and D19B

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	131/569 - (23%)
Similarity:	195/569 - (34%)	Gaps:	123/569 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 LIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNP---PKKEMFSSLIL 356
            |...|.....|.|.....|.:.|...|     |...:::...::.:.:.||   ||::...:...
  Fly   188 LAQRSRRGATRGSKAKGKPKSAAKRQE-----EESEESEETSSSDDSDGNPKDKPKRKRIPATER 247

  Fly   357 G--SVLQCEFCEYIFADIAELLVHSASHVAERRFECT--ACDIQMNTAKEASIHFQTDCIFMREA 417
            .  .::.|..|...|........|...|.....|:||  :|.....||....:|
  Fly   248 DRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVH----------- 301

  Fly   418 IRSLNVTLSRYFVCNV--CELKFANTDLLQEHRCTSFHYFPRLNE-NGKKLLLPCDFCDVNFEFA 479
            :...:...|....|..  |...||...||      ||| ..|::: :..:...||..|:..|.
  Fly   302 VEHAHTETSAMHPCTYEGCNKSFARPVLL------SFH-MKRVHKVDTPQRDFPCTECEKVFR-- 357

  Fly   480 HDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEE 544
               ...:.:||:.|.          .|....:.|:||||.:..:|.|..||..|.|:|..||  .
  Fly   358 ---CPTALKKHMYKH----------TGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVC--P 407

  Fly   545 NCDRKFTIRPDLNDHIRKCHTGERPYLCLVC-----GKRFLTGSVFYQHRLIHRGERRYECEECG 604
            .|....|.|.:.|.|| ..||.|:.|.|..|     .|:.|...|    :::|...:.:.|:.||
  Fly   408 YCGVGKTTRQEWNKHI-LTHTKEKKYECRQCDHASHNKQALANHV----KVVHEKRKDFACQYCG 467

  Fly   605 KRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLET 669
            |.|.::.|.|.|:|.|||||...|..|.|.|.......||::. |...|        :.|.|...
  Fly   468 KTFGKSHACKIHERSHTGEKCCECKICGKVFLFEKGLTKHLKT-HEKRD--------LPKTQGTN 523

  Fly   670 A----------AAQKAQSH---NPEQQDNDVAGGASTSDVPS----------------------- 698
            |          ...|...|   ..|:.|.....|...:.:||
  Fly   524 ALMGDGASGSSTIAKPSPHLRGRVERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPD 588

  Fly   699 -GSGFMSTEPSVAEMQYSITPEQQEEMVC--VPIDEVNNSFFMSH-YMQA--VPMEEDGSGQHII 757
             |.||  ...|..::.|.:..::.::..|  .|.......:...| |:..  .|.|....|:|
  Fly   589 CGKGF--NHVSNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRHHEYIHTGEKPYECKVCGKH-- 649

  Fly   758 VFEQPGQNMDMMSIYDQQQVGEPMHESGVPKRPAEENAR--VVVVKNNP 804
             |.|.......|.::|     :|....|.||.||...|.  ..|.:..|
  Fly   650 -FRQEQVLKTHMKVHD-----KPPRPPGKPKEPAGPKAESSTAVKRQQP 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368	1/1 (100%)
		C2H2 Zn finger	431..453	CDD:275368	7/23 (30%)
		COG5048	<450..647	CDD:227381	62/202 (31%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	20/50 (40%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	10/30 (33%)
		C2H2 Zn finger	572..592	CDD:275368	5/24 (21%)
		zf-H2C2_2	585..609	CDD:290200	6/23 (26%)
		zf-C2H2	598..620	CDD:278523	9/21 (43%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	13/24 (54%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	283..335	CDD:275368	16/69 (23%)
		C2H2 Zn finger	318..338	CDD:275368	9/26 (35%)
		COG5048	<347..512	CDD:227381	58/187 (31%)
		C2H2 Zn finger	349..369	CDD:275368	5/24 (21%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		C2H2 Zn finger	406..426	CDD:275368	7/22 (32%)
		C2H2 Zn finger	434..455	CDD:275368	5/24 (21%)
		C2H2 Zn finger	463..483	CDD:275368	9/19 (47%)
		C2H2 Zn finger	491..511	CDD:275368	6/20 (30%)
		C2H2 Zn finger	586..607	CDD:275368	5/22 (23%)
		C2H2 Zn finger	615..635	CDD:275368	4/19 (21%)
		zf-H2C2_2	627..652	CDD:290200	7/27 (26%)
		C2H2 Zn finger	643..663	CDD:275368	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930