Protein Alignment topi and CG12605

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_647845.2
• Gene: CG12605 / 38468
• FlyBaseID: FBgn0035481
• Length: 619
• Species: Drosophila melanogaster
• Alignment Length: 662
• Identity: 131/662 - (19%)
• Similarity: 206/662 - (31%)
• Gaps: 266/662 - (40%)

  Fly     8 EYTLAEIEVELDQQLTPDDLQPG-----ATVLATNESTGGLERIVSH---EELSRFFAVGPA--- 61
            |::.|:..|:::........:.|     |||.|...::..|.|.|..   |:....|...||
  Fly   126 EWSAAQSLVQMNSSKQEKQRRAGTTGSPATVAAPVSASVSLRRPVGRAPAEDGKVIFYAPPASAS 190

  Fly    62 GALPMPTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRD--FLAGVTSSKMTTEQSVFHG 124
            |:...|..|.::|.          :|.|.::..:.:.|:.::|:  .:|.      |...|::.|
  Fly   191 GSPRQPEPVALKRE----------RERDKEREREKERERDRMREQQLVAA------TAAASIYRG 239

  Fly   125 SRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPAS 189
            .                                      :|.:.|..|.:.::|....||..|..
  Fly   240 R--------------------------------------SVEETEAAHDLLSLSQSLPPLIPPCV 266

  Fly   190 ERVIRENQVRLR--------------------RYIKDEMKYDLATGIESSRKNAAKGPNECTMCD 234
            ..::::.|.:||                    |:| ....|||..|       :::|.|.|
  Fly   267 VTIMKQEQEQLRSPEIQEISNSASSRSPQSTIRFI-GSSSYDLMGG-------SSEGANNC---- 319

  Fly   235 RKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDS 299
                  |.|......|:.|:....:|                                      |
  Fly   320 ------SPLTPPNSDHSSDVDIDMSS--------------------------------------S 340

  Fly   300 EHSTMRQ--SPMTQVPSNRADFNEL---LLDGEMLIDNDPAFATSNQNTNPP----KKEMFSSLI 355
            ..|.::|  .|..|....||...::   :|||......  |.|.:.|:...|    .|...|:..
  Fly   341 SESGLQQWGKPNPQQNQQRASALKMCLNMLDGRTKASK--AAAVTKQDRQEPMQPRPKSAQSNAS 403

  Fly   356 LGSVLQCEFCEYIFADIAELLVHSAS----HVAERR---FECTACDIQMNTAKEASIHFQTDCIF 413
            .|.....|..|    :.|..|.||:|    :.|:|:   ::|..|..|..|:...|.|.||.
  Fly   404 SGGGPPSEPPE----NPAASLGHSSSGNGENYAKRKRGCYKCCECGKQYATSSNLSRHKQTH--- 461

  Fly   414 MREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEF 478
                 |||:...::  .||.|...:.:...|..|..|
  Fly   462 -----RSLDSQSAK--KCNTCGKAYVSMPALAMHLLT---------------------------- 491

  Fly   479 AHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQE 543
             |. |:||                          ||||||.:::...|..|||
  Fly   492 -HK-LSHS--------------------------CDICGKLFSRPWLLQGHLR------------ 516

  Fly   544 ENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFY 608
                               .||||:||.|:.|||.|...|....|...|.|::.::|..|.|.|
  Fly   517 -------------------SHTGEKPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTF- 561

  Fly   609 RADALKNHQRIH 620
               |||::...|
  Fly   562 ---ALKSYLNKH 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	3/19 (16%)
		C2H2 Zn finger	277..297	CDD:275370	0/19 (0%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	38/171 (22%)
		C2H2 Zn finger	469..490	CDD:275368	4/20 (20%)
		C2H2 Zn finger	513..564	CDD:275368	10/50 (20%)
		C2H2 Zn finger	541..561	CDD:275368	0/19 (0%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:463886	4/9 (44%)
		C2H2 Zn finger	628..646	CDD:275368
CG12605	NP_647845.2	COG5048	283..>561	CDD:227381	89/436 (20%)
		zf-C2H2	439..461	CDD:395048	7/21 (33%)
		C2H2 Zn finger	441..461	CDD:275370	7/19 (37%)
		C2H2 Zn finger	472..492	CDD:275368	6/48 (13%)
		zf-C2H2	496..518	CDD:395048	12/78 (15%)
		C2H2 Zn finger	498..518	CDD:275368	10/50 (20%)
		zf-H2C2_2	511..534	CDD:463886	14/53 (26%)
		zf-C2H2	524..546	CDD:395048	8/21 (38%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	538..562	CDD:463886	7/27 (26%)
		C2H2 Zn finger	554..571	CDD:275368	8/21 (38%)