DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Kr

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001261181.1	Gene:	Kr / 38012	FlyBaseID:	FBgn0001325	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	369	Identity:	94/369 - (25%)
Similarity:	143/369 - (38%)	Gaps:	83/369 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 LQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNT--GAG 506
            |.....|..|:.|.  :..:||.:..:| ......:.:.:.|:....::.........:|  |||
  Fly   143 LNSPNSTPQHHEPA--KKARKLSVKKEF-QTEISMSVNDMYHTSGGPISPPSSGSSPNSTHDGAG 204

  Fly   507 -------------RIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLND 558
                         |.:.:.|.||.:|:.....|..|.|.|.|.|||.|.|  |.::||....|..
  Fly   205 GNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQNHERTHTGEKPFECPE--CHKRFTRDHHLKT 267

  Fly   559 HIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGE 623
            |:| .||||:||.|..|.::|:..:...:|..:|.|||.|.||.|..:|..::.||:|..:|.||
  Fly   268 HMR-LHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNGE 331

  Fly   624 KPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQQDNDVA 688
            ||:.|..|...||:|           .|| .|.:..:|..    .|.|...|.|
  Fly   332 KPFECERCHMKFRRR-----------HHL-MNHKCGIQSP----PTPALSPAMS----------- 369

  Fly   689 GGASTSDVPSGSGFMSTEPSVAEMQYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAVPMEEDGSG 753
                 .|.|.....::.|.|.          .:...:|......|.|..|.   :|.| |:||.
  Fly   370 -----GDYPVAISAIAIEAST----------NRFAAMCATYGGSNESVDME---KATP-EDDGP- 414

  Fly   754 QHIIVFEQPGQNMDMMSIYDQQQVGEPMHESGVPKRPAEENARV 797
              :.:.|....::|             .|.|.:.:|.|::..||
  Fly   415 --LDLSEDGASSVD-------------GHCSNIARRKAQDIRRV 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368	2/8 (25%)
		COG5048	<450..647	CDD:227381	64/211 (30%)
		C2H2 Zn finger	469..490	CDD:275368	2/20 (10%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	20/50 (40%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	12/25 (48%)
		C2H2 Zn finger	572..592	CDD:275368	4/19 (21%)
		zf-H2C2_2	585..609	CDD:290200	10/23 (43%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	11/24 (46%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
Kr	NP_001261181.1	C2H2 Zn finger	224..244	CDD:275368	7/19 (37%)
		zf-H2C2_2	237..261	CDD:290200	12/25 (48%)
		C2H2 Zn finger	252..272	CDD:275368	8/22 (36%)
		zf-H2C2_2	264..289	CDD:290200	12/25 (48%)
		C2H2 Zn finger	280..300	CDD:275368	4/19 (21%)
		zf-H2C2_2	292..316	CDD:290200	9/23 (39%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		zf-H2C2_2	321..345	CDD:290200	11/23 (48%)
		C2H2 Zn finger	336..352	CDD:275368	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010