DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and pita

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	815	Identity:	158/815 - (19%)
Similarity:	274/815 - (33%)	Gaps:	282/815 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 AEQMKIRDFLAGVTSSKM----TTEQ---SVF-HGSRSNSSASTVNRIKCPTCLVQFDAVAFQNH 154
            |.::::|:  |.:|..::    .|||   |:| ...|..::|:...:|...|.:..:.......|
  Fly     2 AAKLEVRE--AMLTEKRVCRFCLTEQKLASIFEENPRVKTTANLPLQIMAITAIEVYAGDGMPGH 64

  Fly   155 SC---------------EAKPIEVAVPQQ----------EKPH------------LVPTVSAPPA 182
            .|               ..|..|..:.|.          |||.            :||..:|.|:
  Fly    65 ICLECRLLFEHCYRFKQMCKRAETLLRQYPLTGNWPSPLEKPRAPMTMVASKKLLVVPAKTAEPS 129

  Fly   183 --------PLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGP------------ 227
                    .::|.:|:.:|.:.||             |.:.:.:.|..|...|
  Fly   130 ETPKKLLNTMAKSSSQVIIEDVQV-------------LESAMVTPRTVAGSSPVPRRSHAYELKV 181

  Fly   228 ---NECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQV 289
               .|.:|.|.:.: ...:...:||...|:....:..:|..:..:.:.::.|..:..   .:|::
  Fly   182 DNNQELSMDDVQSM-LEDMASELEKEFPDIPQKASPVKPKVLNKSSIRILNKGPAAP---VEPRL 242

  Fly   290 AFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLID--NDPAFATSNQNTNPPKKEMFS 352
            |.......||.:..:    :|:|           ||.::.:|  :||   |.|           :
  Fly   243 ATPKVKRDDSGNVAI----VTEV-----------LDSDLPLDDQDDP---TKN-----------A 278

  Fly   353 SLILGSVLQCEFCEYIFADIAELL-VHSASHVAERRFECTACD----IQMNTAKEASIHFQTDCI 412
            ..:...|..|..||..| .:.:|| :|..:|...|.|:|..|:    .:.:.||...:|
  Fly   279 EKVATDVFPCPDCERSF-PLQQLLEIHRLNHTRSRSFQCLLCEKSFFSKYDLAKHNFVH------ 336

  Fly   413 FMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFE 477
                       |..|.|.|.:|...|....||..|.        |.:.:..|.:  |.:|:
  Fly   337 -----------TGERPFKCAICSKAFTRKALLHRHE--------RTHTDVPKFI--CVYCE---- 376

  Fly   478 FAHDFLAHSE-EKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVC 541
              ..||:..| |||..:.:::           |.:.|.:|.||:.....|.:|...|....||.|
  Fly   377 --KPFLSRQEMEKHAERHQKK-----------RPFQCGVCTKSFAFKQGLERHETVHSTNLPFPC 428

  Fly   542 QEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTG-----------------------S 583
            |  :|:|.|:....|..|: ..|.|:|.|.|..|.|.::..                       .
  Fly   429 Q--HCERSFSTASKLARHL-VAHAGKRAYPCKYCHKSYMLSHHLSRHLRTHTQTSDASFVCSECK 490

  Fly   584 VFY-------QHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDR 641
            |.|       .|.||| .....:|..|.|:....|::::|...|...:.::|.||...|..:...
  Fly   491 VSYSNYNDLLDHALIH-ATASLKCPMCRKQIEDIDSVESHMDQHKQSERHACEFCDHIFLTQKCL 554

  Fly   642 DKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTE 706
            .:||...|         :::|:.:|            |..:.|.:..||
  Fly   555 QRHIEDDH---------VVEMEPYQ------------NEFEDDGEGEGG---------------- 582

  Fly   707 PSVAEMQYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAVPMEEDGSGQHIIVFEQPGQNMDMMSI 771
              |.|.:..:  :..|:|     |.|....|::.|::...:.||    |:
  Fly   583 --VDEKEEHL--DDFEDM-----DNVKQEEFVTEYLEDDALYED----HL--------------- 619

  Fly   772 YDQQQVGEPMHESGVPKRPAEENARVVVVKNNPTK 806
                   :...||..|..|.:.       |.||.|
  Fly   620 -------DDSDESFTPPPPKQR-------KTNPPK 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	3/19 (16%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	52/227 (23%)
		C2H2 Zn finger	469..490	CDD:275368	6/21 (29%)
		zf-C2H2	511..533	CDD:278523	6/21 (29%)
		C2H2 Zn finger	513..564	CDD:275368	16/50 (32%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	9/25 (36%)
		C2H2 Zn finger	572..592	CDD:275368	7/49 (14%)
		zf-H2C2_2	585..609	CDD:290200	8/30 (27%)
		zf-C2H2	598..620	CDD:278523	5/21 (24%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		zf-H2C2_2	612..637	CDD:290200	6/24 (25%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
pita	NP_611806.3	zf-AD	17..92	CDD:214871	13/74 (18%)
		COG5048	<281..506	CDD:227381	63/272 (23%)
		C2H2 Zn finger	288..308	CDD:275368	7/20 (35%)
		C2H2 Zn finger	316..336	CDD:275368	4/19 (21%)
		zf-H2C2_2	328..353	CDD:290200	9/41 (22%)
		C2H2 Zn finger	344..364	CDD:275368	7/27 (26%)
		C2H2 Zn finger	372..388	CDD:275370	6/21 (29%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	428..448	CDD:275368	7/22 (32%)
		C2H2 Zn finger	456..476	CDD:275368	3/19 (16%)
		C2H2 Zn finger	486..506	CDD:275368	4/19 (21%)
		HARE-HTH	<566..625	CDD:294801	17/121 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030