DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and Oaz

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	170/969 - (17%)
Similarity:	269/969 - (27%)	Gaps:	393/969 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ELDQQLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPMPTDVVVERTLADPA- 80
            |..||..|...:|.|......|.    |.....|||..            |.|.||....|..|
  Fly    72 ESQQQSWPTADEPAAPAAVAKEE----EAEEGSEELQH------------PRDEVVASDAAANAN 120

  Fly    81 --FKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSK---------MTTEQSVFHGSRSNSSAS-- 132
              .|....|.|.....:|  |.:::.|.|..::..:         :.:..|..:.:.::||.|
  Fly   121 GHCKSSGHEEDAVDAEEP--EDLELDDELLSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSYSPS 183

  Fly   133 ------TVNR---IKCPTCLVQFDAVAFQNHSCEAK----------PIEVAVPQQEKPHLVPTVS 178
                  |.|.   |..||      |...::|..|.|          |....:|.....|
  Fly   184 ISDGTMTPNSHHLIGAPT------AAGQEDHPTEGKINGGADGEDLPKPKRLPHFHHHH------ 236

  Fly   179 APPAPLSKPASERVIRENQV-----RLRRYIKD--------------EMKYDLATGIESSRKNAA 224
                       .......|.     :||:..|:              ..|:|..||  ...|:..
  Fly   237 -----------HHHYHHQQALKIANKLRKINKEAKMGATAGGGATGAASKFDKLTG--EGIKSRG 288

  Fly   225 KGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQV 289
            .|..:|..|::.|.....|..|::.||                   .|:..||..|.::|...:.
  Fly   289 DGSYQCQFCEKTFPRLGYLKHHVQSHA-------------------EHLPFKCEYCSKLFKHKRS 334

  Fly   290 AFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSL 354
            ..||..:|.:|.:
  Fly   335 RDRHKKLHTNERN---------------------------------------------------- 347

  Fly   355 ILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQ----------- 408
                 .:|..||..|:....|.:|..:|..::.|:|:.|:...|||...:.|.|
  Fly   348 -----YKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAA 407

  Fly   409 ----TDCIFMREAIRSLNVTLS--------RYFV------------------------------- 430
                ....:...:..|.:.::|        ||.:
  Fly   408 GGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGGTTTTATP 472

  Fly   431 -----CNVCE--LKFANTDLLQEHRCTSFHYFPRLN------ENGKKLLLPCDFCDVNFE----- 477
                 |:.|.  .:|::.:.|..| ..|.|..|:..      :.|:...|.|::|.:.|.
  Fly   473 TPLLRCSYCPKVTEFSSLEQLNAH-LQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIAGL 536

  Fly   478 FAHDFLAHSEE--------KHLNK----------------------KKREKETR----------- 501
            |.|....|.:.        :|.|:                      ...|:|:|
  Fly   537 FQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERESRPAEDDLPTDLS 601

  Fly   502 --------------------------------NTGAGRIR--------------QYLCDICGKSY 520
                                            |.|.....              |.:|..||.|.
  Fly   602 NNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLVCPHCGMSL 666

  Fly   521 TQSSHLWQHLRFHQGV--KPFVCQEENCDRKFTIRPDLNDH--------IRKC------------ 563
            .:.|...:|:..|..:  ..|.| ..:|.:.|....||..|        :.||
  Fly   667 PEQSEFERHVVGHFLITGSEFNC-SSSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRMA 730

  Fly   564 --------HTGERPYL-CLVCGKRFLTGSVFYQH-RLIHR-------------GERRYECEECGK 605
                    |:.|...| |..|.:.|.:.:.|:.| :..|:             .....:|..|
  Fly   731 MQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMFC-- 793

  Fly   606 RFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHL---DANSRLMMQMQKFQL 667
            |...:..|:.|..:....:.:.|..|.:||......|:|::::|..:   :|||..|..:....|
  Fly   794 RAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDKEANSPNMGSLYVNAL 858

  Fly   668 -----ETAAAQKAQSHNPEQQDNDVA-----GGASTSDVPSGSGFMS-TEPSVAEMQYS 715
                 ..|||..|.::|....|.:||     ||||......|.|..| ..|..|...||
  Fly   859 LPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAPPSANKFYS 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	6/23 (26%)
		COG5048	<450..647	CDD:227381	55/339 (16%)
		C2H2 Zn finger	469..490	CDD:275368	6/33 (18%)
		zf-C2H2	511..533	CDD:278523	6/21 (29%)
		C2H2 Zn finger	513..564	CDD:275368	16/80 (20%)
		C2H2 Zn finger	541..561	CDD:275368	6/27 (22%)
		zf-H2C2_2	555..581	CDD:290200	11/54 (20%)
		C2H2 Zn finger	572..592	CDD:275368	5/20 (25%)
		zf-H2C2_2	585..609	CDD:290200	6/37 (16%)
		zf-C2H2	598..620	CDD:278523	5/21 (24%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		zf-H2C2_2	612..637	CDD:290200	6/24 (25%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	322..342	CDD:275368	5/19 (26%)
		zf-H2C2_2	334..359	CDD:290200	8/81 (10%)
		COG5048	336..769	CDD:227381	71/491 (14%)
		zf-C2H2	348..370	CDD:278523	6/21 (29%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	630..650	CDD:275368	2/19 (11%)
		C2H2 Zn finger	659..679	CDD:275368	6/19 (32%)
		C2H2 Zn finger	689..707	CDD:275368	5/18 (28%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446607
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930