DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and CG17328

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_609786.2	Gene:	CG17328 / 34962	FlyBaseID:	FBgn0028895	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	75/305 - (24%)
Similarity:	122/305 - (40%)	Gaps:	64/305 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 CTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCEL----KFANTDLLQEHRCT 450
            |..|..::..|    .||:.:|       .:.::.|.:|.  .:.|.    ...|||.:::
  Fly    54 CNNCIYRLGVA----FHFKQEC-------ENSDLRLRQYL--GILESWRQDAATNTDFVEK---- 101

  Fly   451 SFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQ--YLC 513
                 |.|.:.......|.|            ...|:.:...::|..:|.:..|...:.:  :.|
  Fly   102 -----PLLPQRDSDEEEPVD------------AKVSKRRSRYQRKPPEEHKKRGPKPVPKMPHTC 149

  Fly   514 DICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKR 578
            ..|.||:...:.|.||:|.|.|.||:.|  ..|.::|..:.:|..| .:.|||::|:.|.:|.|:
  Fly   150 YECHKSFKCIAQLTQHIRTHTGEKPYQC--SFCIQRFAQKYNLKVH-ERTHTGDKPFQCEICSKQ 211

  Fly   579 FLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDK 643
            |.....|..|:.||.|.|...|..|.|.||.|..|..|...|||.|.:.|..|.|.|.:|.|
  Fly   212 FSALGNFQAHQKIHLGVRDQVCSLCQKGFYTAGDLSKHMITHTGIKNHHCDVCGKAFSRRRD--- 273

  Fly   644 HIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQQDNDVA 688
                              |:..:|:....:.:.:|:....|:|.|
  Fly   274 ------------------MRTHKLKLHPLESSTNHDIVDDDDDEA 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368	4/25 (16%)
		COG5048	<450..647	CDD:227381	57/198 (29%)
		C2H2 Zn finger	469..490	CDD:275368	2/20 (10%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	17/50 (34%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..581	CDD:290200	10/25 (40%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	10/23 (43%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	10/24 (42%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
CG17328	NP_609786.2	zf-AD	8..80	CDD:214871	7/36 (19%)
		COG5048	146..>211	CDD:227381	23/67 (34%)
		C2H2 Zn finger	149..169	CDD:275368	8/19 (42%)
		C2H2 Zn finger	177..197	CDD:275368	5/22 (23%)
		zf-H2C2_2	189..213	CDD:404364	9/24 (38%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		C2H2 Zn finger	233..253	CDD:275368	8/19 (42%)
		zf-H2C2_2	245..270	CDD:404364	10/24 (42%)
		C2H2 Zn finger	261..282	CDD:275368	8/41 (20%)
		C2H2 Zn finger	318..338	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446698
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930