DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and ZNF879

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001129588.1	Gene:	ZNF879 / 345462	HGNCID:	37273	Length:	563	Species:	Homo sapiens

Alignment Length:	451	Identity:	125/451 - (27%)
Similarity:	172/451 - (38%)	Gaps:	142/451 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 NAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYD 286
            |..:...:|.:|.:.|:|:|.|.:|...|        |.|:           :.||..|.:.|..
Human   198 NTVRKCYKCNICGKIFLHSSSLSKHQRIH--------TGEK-----------LYKCKECRKAFSQ 243

  Fly   287 PQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMF 351
            .....:|..:|..|...:
Human   244 SSSLTQHLRVHTGEKPYI----------------------------------------------- 261

  Fly   352 SSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMRE 416
                      |..|...|:....|:.|...|..||.::|..|.   .|.|.:|
Human   262 ----------CSECGKAFSFTTSLIGHQRMHTGERPYKCKECG---KTFKGSS------------ 301

  Fly   417 AIRSLN-----VTLSRYFVCNVCELKFAN-TDLLQEHR---------CT----SFHYFPRLNEN- 461
               |||     .|..:.:.||.|...|:. :.|:|.||         ||    :|....||:.:
Human   302 ---SLNNHQRIHTGEKPYKCNECGRAFSQCSSLIQHHRIHTGEKPYECTQCGKAFTSISRLSRHH 363

  Fly   462 ----GKKLLLP--CDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSY 520
                |:|   |  |:.|...|.: |..|...:..|..:|               .|.|..|||::
Human   364 RIHTGEK---PFHCNECGKVFSY-HSALIIHQRIHTGEK---------------PYACKECGKAF 409

  Fly   521 TQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVF 585
            :|||.|.||.|.|.|.||:.|.|  |.:.|:....||.| .:.||||:||.|..|||.|.:.|..
Human   410 SQSSALIQHQRIHTGEKPYKCNE--CGKAFSWISRLNIH-HRIHTGEKPYNCKECGKAFSSHSGV 471

  Fly   586 YQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIR 646
            ..||.||.||:.|:|.:|.|.|.::.||..|||||||||||:|..|.|.|||......|:|
Human   472 NTHRKIHTGEKPYKCNDCEKAFNQSSALIQHQRIHTGEKPYNCKVCGKAFRQSSSLMTHMR 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	431..453	CDD:275368	10/35 (29%)
		COG5048	<450..647	CDD:227381	81/208 (39%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	12/21 (57%)
		C2H2 Zn finger	513..564	CDD:275368	22/50 (44%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	14/25 (56%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..609	CDD:290200	11/23 (48%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	17/24 (71%)
		C2H2 Zn finger	628..646	CDD:275368	7/17 (41%)
ZNF879	NP_001129588.1	KRAB	14..74	CDD:214630
		COG5048	202..558	CDD:227381	124/447 (28%)
		C2H2 Zn finger	206..226	CDD:275368	7/19 (37%)
		C2H2 Zn finger	234..254	CDD:275368	4/19 (21%)
		C2H2 Zn finger	262..282	CDD:275368	5/19 (26%)
		C2H2 Zn finger	290..310	CDD:275368	8/37 (22%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		C2H2 Zn finger	346..366	CDD:275368	5/19 (26%)
		C2H2 Zn finger	374..394	CDD:275368	5/20 (25%)
		C2H2 Zn finger	402..422	CDD:275368	11/19 (58%)
		C2H2 Zn finger	430..450	CDD:275368	7/22 (32%)
		C2H2 Zn finger	458..478	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..506	CDD:275368	9/19 (47%)
		C2H2 Zn finger	514..534	CDD:275368	8/19 (42%)
		C2H2 Zn finger	542..562	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910