DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and CG17612

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster

Alignment Length:	663	Identity:	133/663 - (20%)
Similarity:	216/663 - (32%)	Gaps:	215/663 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KVSGEYTLAEIEVELDQQLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPMPT 68
            ::.|...:.::||..:.:...|       |:...:|..  |.::..:.             |...
  Fly    99 EIIGASNIVDVEVHENHRANND-------VILIQDSFA--EEVILEDH-------------PANN 141

  Fly    69 DV-VVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDFL--AGVTSSKMTTEQS-----VFHGS 125
            || :::.::|:.....|.:||  .:|.|.|.|...|.:.|  ..:.|.::..|||     :|..:
  Fly   142 DVIIIQDSVAEEELPVIKEEA--IEGEDLQGEYFIITECLEEPAIGSCRVCLEQSDNLTNIFDDA 204

  Fly   126 RSN----------------SSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLV 174
            ...                ....:.:...|.|||   |.|.......|:|...:.:.:|.|..::
  Fly   205 HQYGIPIATILSQYTGMPVEKGDSFSEYICVTCL---DVVKNAFDDLESKENTIQMYRQPKEEII 266

  Fly   175 PTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVH 239
            ...|.|..  :||....|                     ||         |.|:.|..|.:.|:.
  Fly   267 DIDSIPVK--NKPVDYEV---------------------TG---------KPPHRCPQCPKIFLL 299

  Fly   240 ASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTM 304
            |:.|..|:..|.    .::|:|.|.          :||..|..|:........|..||.:  |..
  Fly   300 AAKLQAHIRTHN----ETRTTEPPR----------LKCPMCPSIYMKRGCLEAHMWIHRA--SDE 348

  Fly   305 RQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSS---------------L 354
            |:|.:                       :|.:    :..:.||..::||               |
  Fly   349 RESEL-----------------------EPPY----RCPHCPKLFLYSSFLEIHIQTHEDVSQRL 386

  Fly   355 ILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASI------HFQTDCIF 413
            ...|..:|..|..:|:|::.|..|...|..||.|:|..|  .|:..:|:::      |.:..|..
  Fly   387 SRKSSHKCAQCADVFSDVSSLKDHVKIHAGERTFKCPLC--LMSFQEESNLKSHDCAHTRFKCHK 449

  Fly   414 MREAIRSLNV---------TLSRYFVCNVCELKFANTDLLQEH----RCTSFHYFPRLNENGKKL 465
            ..:...|.|.         |....|.|..|:..|...:.|:||    .|..|     |.......
  Fly   450 CSKFFESQNYLDFHFKKSHTTKGPFKCIKCQQTFQKRNGLKEHISSQVCVQF-----LRSKSPGQ 509

  Fly   466 LLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHL 530
            :.||..|...|....::..|    |...||.:..        |.::.|..|.|||.....|.:|:
  Fly   510 IFPCPKCPKKFSIEDNYQMH----HATHKKVKTV--------IERHNCTQCKKSYQNKKLLTKHI 562

  Fly   531 RFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRF-LTGSVFYQHRLIHRG 594
            ..|..     |  .:|...||.:..|..|              .|.:.: |.||         ||
  Fly   563 LSHNR-----C--VHCSMSFTSKYLLEQH--------------TCSQSYQLNGS---------RG 597

  Fly   595 ERR-----YECEE 602
            .:.     .||||
  Fly   598 RKNPNLNYNECEE 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	431..453	CDD:275368	7/25 (28%)
		COG5048	<450..647	CDD:227381	35/159 (22%)
		C2H2 Zn finger	469..490	CDD:275368	4/20 (20%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	14/50 (28%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	3/26 (12%)
		C2H2 Zn finger	572..592	CDD:275368	4/20 (20%)
		zf-H2C2_2	585..609	CDD:290200	6/23 (26%)
		zf-C2H2	598..620	CDD:278523	4/5 (80%)
		C2H2 Zn finger	600..620	CDD:275368	3/3 (100%)
		zf-H2C2_2	612..637	CDD:290200
		C2H2 Zn finger	628..646	CDD:275368
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	10/61 (16%)
		C2H2 Zn finger	290..310	CDD:275368	6/19 (32%)
		C2H2 Zn finger	323..343	CDD:275370	4/19 (21%)
		zf-C2H2_8	356..438	CDD:292531	20/87 (23%)
		C2H2 Zn finger	359..379	CDD:275368	4/19 (21%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	422..438	CDD:275368	4/17 (24%)
		C2H2 Zn finger	447..463	CDD:275368	3/15 (20%)
		C2H2 Zn finger	476..505	CDD:275368	9/33 (27%)
		C2H2 Zn finger	513..533	CDD:275368	5/23 (22%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		C2H2 Zn finger	568..584	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030