DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and CG3407

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_608809.1	Gene:	CG3407 / 33606	FlyBaseID:	FBgn0031573	Length:	714	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	175/763 - (22%)
Similarity:	265/763 - (34%)	Gaps:	208/763 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GATVLATNESTGGLERIVS-------------HEELSRFFAVGPAGALPMPTDVVVERTLADPAF 81
            |.|.|:||.|:|..|..|.             |..:.:|     ........|||..:..|.|.|
  Fly    34 GPTNLSTNPSSGNSESGVGYVEKESLTPELNFHNTIFQF-----VNKSSPENDVVPHQVDAQPTF 93

  Fly    82 KQILQE----ADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVF-------------------H 123
            ..:..|    .|...|....      .|.|....::..|..:.|.                   |
  Fly    94 PALAIEPTVPIDVSTGLHED------EDLLYAHNNASCTNARKVLPHKKRISRKLKGNIDPELDH 152

  Fly   124 GSRSNSSASTVNRIKCPTC----LVQFDAVAFQNHSCEAKPIE----VAVPQQEKPHLVPTVSAP 180
            ..:.....:..:...|..|    ..|.|..|......|...:|    |..|||:..      ...
  Fly   153 QHKHVQDVAPSSLYSCEICGYAVHTQLDFFAHLKQHYEPTVLEQRLVVQDPQQQHQ------QKE 211

  Fly   181 PAPLSKPASERVIRENQVRLRRYIKD-EMKYDLATGIESSRKNAAK-GPNECTMCDRKFVHASGL 243
            |..:...:::..:::.|.:|.:..:| ::.::....|.....:.|. |.|              :
  Fly   212 PLDMCGLSAQDKLQQEQAKLDQVFQDVQLNFENFHNISHHVNDVANVGVN--------------M 262

  Fly   244 VRH-MEKHALDLIPSQTSEQPHTIPAA-------------GLHVVVKC----NSCGRIFYDPQVA 290
            |.| .....|:.:...||..|:::|..             |:..||..    ::|..:.
  Fly   263 VLHGQATDKLNAVVVNTSSTPNSVPVVDDVEFSDTEDMLEGIRNVVDKVSIEDTCDELV------ 321

  Fly   291 FRHGLIHDSEHSTMRQSPMTQVP---SNRAD--FNELLLDGEMLIDNDPAFATSNQNTNPPKKEM 350
                   |.|   :..|.|| .|   :|..|  |..|||.||    ..||   |::...|..||
  Fly   322 -------DLE---LTSSGMT-APWFNNNFRDITFPALLLPGE----PPPA---SSEPATPLLKE- 367

  Fly   351 FSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECT---ACDIQMNTAKEASIHFQTDCI 412
              :..:|..:..:|.....||..|          |.:.|.|   ||:....|...|....||..|
  Fly   368 --NPHVGDHMALDFLSPEKADPQE----------EAKLEKTLSKACEPNEQTLLVAPPACQTPPI 420

  Fly   413 -------FMREAIRSLNVTLSRYFVC------------------------NVC-ELKFANTDLLQ 445
                   ...|.:|...:.||..|..                        |.| :::..:|.|.:
  Fly   421 PTVPPANSSIEQLRRSPLELSEAFKLEEDDMTDSRPASSFEEGDPDAEEPNECFQMEVLDTSLTE 485

  Fly   446 EHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQ 510
            |..          |:..:|..  ||.|:      .||.::      |..|..:.|.|    :.|.
  Fly   486 EAE----------NKTRRKHF--CDKCN------RDFNSY------NALKYHQYTHN----QERS 522

  Fly   511 YLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVC 575
            :.||.|.:|:...|.|..|.|.|.|||||.|  :.|:.:|....||..||...|:..:.::|..|
  Fly   523 HKCDSCERSFYTQSALKAHERTHSGVKPFKC--DKCEFQFRQWGDLKYHIISRHSDVKAHMCEFC 585

  Fly   576 GKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGD 640
            ||.|........||.||..|:.|.|:.|.|.|..:..|.:|.::||||:||.|..|.|.||..||
  Fly   586 GKSFSRRYSLVVHRRIHTREKNYACQYCDKTFRASSYLLSHIKVHTGERPYECSICEKKFRVSGD 650

  Fly   641 RDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQQDNDVA 688
            ..:|.|..    |.:.......:|.:.:.|||...|.  |.::|:::|
  Fly   651 LKRHSRIH----DPSRTSQPPAEKAKKKRAAASNKQL--PIEEDDELA 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	2/20 (10%)
		C2H2 Zn finger	277..297	CDD:275368	1/23 (4%)
		C2H2 Zn finger	431..453	CDD:275368	5/46 (11%)
		COG5048	<450..647	CDD:227381	65/196 (33%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	21/50 (42%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	10/25 (40%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	10/23 (43%)
		zf-C2H2	598..620	CDD:278523	7/21 (33%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:290200	12/24 (50%)
		C2H2 Zn finger	628..646	CDD:275368	8/17 (47%)
CG3407	NP_608809.1	COG5048	<494..656	CDD:227381	64/181 (35%)
		C2H2 Zn finger	497..517	CDD:275368	7/31 (23%)
		zf-H2C2_2	509..534	CDD:290200	8/28 (29%)
		C2H2 Zn finger	525..545	CDD:275368	8/19 (42%)
		zf-H2C2_2	537..562	CDD:290200	12/26 (46%)
		C2H2 Zn finger	555..574	CDD:275371	6/18 (33%)
		zf-C2H2	580..602	CDD:278523	7/21 (33%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
		zf-H2C2_2	594..617	CDD:290200	9/22 (41%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		zf-H2C2_2	622..645	CDD:290200	11/22 (50%)
		zf-C2H2	636..658	CDD:278523	10/21 (48%)
		C2H2 Zn finger	638..658	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100