DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and AgaP_AGAP011405

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_554837.3	Gene:	AgaP_AGAP011405 / 3291310	VectorBaseID:	AGAP011405	Length:	438	Species:	Anopheles gambiae

Alignment Length:	225	Identity:	63/225 - (28%)
Similarity:	97/225 - (43%)	Gaps:	34/225 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 RYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLL-PCDFCDVNFEFAHDFLAHSEEKH 490
            |.::|:.|.:      |:.:        .||...|..||:. .|..|.|......:.|.|.|..|
Mosquito   230 RKYLCDTCGV------LIND--------LPRHTLNHSKLIKHACPHCPVEMVEYSNLLRHIEAVH 280

  Fly   491 LNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGV-KPFVCQEENCDRKFTIRP 554
                  ||..|.:         |::|||.:|.::.|..|:..|.|: ....|:.  |.:.|....
Mosquito   281 ------EKRIRKS---------CELCGKGFTHNNSLVSHMVVHHGIGDTHKCKV--CPKVFRHAS 328

  Fly   555 DLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRI 619
            .|..|::|||:....:.|.:||..|.:.....:|...|..||.|||.||||||....|.:.|::.
Mosquito   329 GLRGHVKKCHSNATKFECSLCGAFFSSRYDLKKHGRSHSSERPYECSECGKRFKSQYARRIHEQA 393

  Fly   620 HTGEKPYSCLFCTKTFRQRGDRDKHIRARH 649
            |:| ..|.|..|.:.:|.:.....|::..|
Mosquito   394 HSG-LLYECDVCRRPYRYKALMRMHMKRTH 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368	3/21 (14%)
		COG5048	<450..647	CDD:227381	58/198 (29%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	15/51 (29%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..581	CDD:290200	9/25 (36%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	585..609	CDD:290200	13/23 (57%)
		zf-C2H2	598..620	CDD:278523	11/21 (52%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	7/24 (29%)
		C2H2 Zn finger	628..646	CDD:275368	4/17 (24%)
AgaP_AGAP011405	XP_554837.3	zf-AD	12..86	CDD:285071
		C2H2 Zn finger	259..280	CDD:275370	6/20 (30%)
		C2H2 Zn finger	288..308	CDD:275370	7/19 (37%)
		C2H2 Zn finger	317..338	CDD:275368	6/22 (27%)
		C2H2 Zn finger	346..366	CDD:275368	5/19 (26%)
		zf-H2C2_2	358..383	CDD:290200	13/24 (54%)
		C2H2 Zn finger	374..394	CDD:275368	9/19 (47%)
		C2H2 Zn finger	401..422	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910