DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and CG2120

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster

Alignment Length:	273	Identity:	73/273 - (26%)
Similarity:	112/273 - (41%)	Gaps:	70/273 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 AIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHD 481
            |::..|.|  .:...::|:.|  .|...:.||.|...:             .||.||..|..|::
  Fly    66 ALQQRNTT--EHKPTDMCKPK--RTPTTKRHRTTGKDH-------------TCDICDRRFSEAYN 113

  Fly   482 F----LAHSEEK------------HLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHL 530
            .    :.|::||            .|||.:....|....    |.:.||||||.:..:::|..|.
  Fly   114 LRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAE----RPHKCDICGKGFRYANYLTVHR 174

  Fly   531 RFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHT-----------GERP-------------YL 571
            |.|.|.||:.|...:|...|.     :.|.|:.||           .|.|             :.
  Fly   175 RLHTGEKPYPCLATDCHLSFH-----SIHARRIHTKLRHAAQTDPDPEHPLAEQEQRDTSALSFT 234

  Fly   572 CLVCGKRFLTGSVFYQ-HRLIHRGERRYEC--EECGKRFYRADALKNHQRIHTGEKPYSCLFCTK 633
            |.|| .|.||...:.. |...|..:|.:.|  .||||||:.|..||:||..||.::|::|..|..
  Fly   235 CPVC-SRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPA 298

  Fly   634 TFRQRGDRDKHIR 646
            .|.::.:..:|::
  Fly   299 RFLRKSNHKQHLK 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	65/240 (27%)
		C2H2 Zn finger	469..490	CDD:275368	9/36 (25%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	18/50 (36%)
		C2H2 Zn finger	541..561	CDD:275368	4/19 (21%)
		zf-H2C2_2	555..581	CDD:290200	10/49 (20%)
		C2H2 Zn finger	572..592	CDD:275368	7/20 (35%)
		zf-H2C2_2	585..609	CDD:290200	10/26 (38%)
		zf-C2H2	598..620	CDD:278523	12/23 (52%)
		C2H2 Zn finger	600..620	CDD:275368	12/21 (57%)
		zf-H2C2_2	612..637	CDD:290200	10/24 (42%)
		C2H2 Zn finger	628..646	CDD:275368	4/17 (24%)
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	3/24 (13%)
		C2H2 Zn finger	129..149	CDD:275368	3/19 (16%)
		zf-H2C2_2	142..166	CDD:290200	8/27 (30%)
		COG5048	151..>264	CDD:227381	32/122 (26%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	7/25 (28%)
		C2H2 Zn finger	235..255	CDD:275368	7/20 (35%)
		C2H2 Zn finger	263..285	CDD:275368	12/21 (57%)
		C2H2 Zn finger	293..313	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930