DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and Zfp746

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:XP_008761109.1 Gene:Zfp746 / 312303 RGDID:1306209 Length:656 Species:Rattus norvegicus


Alignment Length:219 Identity:57/219 - (26%)
Similarity:80/219 - (36%) Gaps:66/219 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   518 KSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKC-------------HTG--- 566
            |.:.....|.:|.....|.:||.|  ..|.:.|.::..|:.|.|.|             .||   
  Rat   439 KGFGHKPGLKKHPAAPPGGRPFTC--ATCGKSFQLQVSLSAHQRSCGLSDGAGTGAASTATGGGG 501

  Fly   567 ----------------ERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKN 615
                            .....|..||:.|...:...:||::|.|||.:.|.||.|||.....|.:
  Rat   502 GGGGGGSSAGGSSARDSSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLID 566

  Fly   616 HQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHN- 679
            |.|.|||.:|::|..|.|:|         ||..|            ::|.|....|..||.:|. 
  Rat   567 HYRTHTGVRPFTCTVCGKSF---------IRKDH------------LRKHQRNHPAVAKAPAHGQ 610

  Fly   680 --------PEQQDNDVAGG--AST 693
                    |:...:..|.|  |||
  Rat   611 PLPPLPAPPDPFKSPAAKGPMAST 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368
COG5048 <450..647 CDD:227381 43/160 (27%)
C2H2 Zn finger 469..490 CDD:275368
zf-C2H2 511..533 CDD:278523 3/14 (21%)
C2H2 Zn finger 513..564 CDD:275368 13/58 (22%)
C2H2 Zn finger 541..561 CDD:275368 5/19 (26%)
zf-H2C2_2 555..581 CDD:290200 10/57 (18%)
C2H2 Zn finger 572..592 CDD:275368 6/19 (32%)
zf-H2C2_2 585..609 CDD:290200 12/23 (52%)
zf-C2H2 598..620 CDD:278523 9/21 (43%)
C2H2 Zn finger 600..620 CDD:275368 9/19 (47%)
zf-H2C2_2 612..637 CDD:290200 11/24 (46%)
C2H2 Zn finger 628..646 CDD:275368 4/17 (24%)
Zfp746XP_008761109.1 KRAB 113..162 CDD:214630
KRAB_A-box <114..141 CDD:143639
COG5048 <522..600 CDD:227381 32/98 (33%)
zf-C2H2 522..543 CDD:278523 6/20 (30%)
C2H2 Zn finger 523..543 CDD:275368 6/19 (32%)
zf-H2C2_2 535..559 CDD:290200 11/23 (48%)
zf-C2H2 549..571 CDD:278523 9/21 (43%)
C2H2 Zn finger 551..571 CDD:275368 9/19 (47%)
zf-C2H2 577..599 CDD:278523 9/42 (21%)
C2H2 Zn finger 579..599 CDD:275368 9/40 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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