DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and CG11398

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001259122.2	Gene:	CG11398 / 31070	FlyBaseID:	FBgn0040366	Length:	329	Species:	Drosophila melanogaster

Alignment Length:	379	Identity:	93/379 - (24%)
Similarity:	143/379 - (37%)	Gaps:	67/379 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 EYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFV 430
            :|..|:|..||.|:   ..:........::|.....|.|.|.|..               |..||
  Fly     5 QYKEAEILALLPHT---YEDEELSLNTEELQFEELNERSQHQQGG---------------SPSFV 51

  Fly   431 CNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLP-----CDFCDVNFEFAHDFLAHSEEKH 490
            |..|...|...:.|..||.|  |.:    :.|::  .|     ||.|...|: .|:.|.    .|
  Fly    52 CRRCPALFLTREELAAHRPT--HRY----QGGQQ--TPASEHACDACGRVFQ-KHNALV----DH 103

  Fly   491 LNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLR-FHQGVKPFVCQEENCDRKFTIRP 554
            :|           ....:|.|.|..|...:.|.|:...||: .|:.|....|.|..|.::|..|.
  Fly   104 MN-----------AHNDVRNYPCPECPARFVQRSNRECHLKNVHRKVYLHSCPEPGCKKRFQQRR 157

  Fly   555 DLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRI 619
            :.:.|::..|..||..:|..|..||.....:.:|...|...:.|.|..|||.|.|.:....|..:
  Fly   158 ECDQHVKTVHQNERNLVCDTCSARFSHPVNYRKHLASHGSAKSYGCPICGKLFGRPENRDVHLFV 222

  Fly   620 HTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQ-SHNPEQQ 683
            |:..|.|.|..|...:.:|....:|..|...|   |..::.|..:|....||..::| |...|.|
  Fly   223 HSICKAYICSVCGADYMRRNQLIRHGLASGHH---NDPIVRQKPQFSPALAAKNRSQRSAIDESQ 284

  Fly   684 DNDV--AGGASTSDVPSGSGFMSTEPSVAEMQYSITPEQQEEMVCVPIDEVNNS 735
            |.::  ..|....|   .:|::...      |:|.|    .:|..:..::.|.|
  Fly   285 DEELQWLKGVDALD---SAGYLENS------QFSNT----GKMTAIFAEDENES 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368	7/21 (33%)
		COG5048	<450..647	CDD:227381	52/202 (26%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		zf-C2H2	511..533	CDD:278523	7/22 (32%)
		C2H2 Zn finger	513..564	CDD:275368	14/51 (27%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	8/25 (32%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	585..609	CDD:290200	8/23 (35%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	6/24 (25%)
		C2H2 Zn finger	628..646	CDD:275368	4/17 (24%)
CG11398	NP_001259122.2	C2H2 Zn finger	52..72	CDD:275368	7/21 (33%)
		C2H2 Zn finger	87..107	CDD:275368	8/35 (23%)
		C2H2 Zn finger	115..136	CDD:275368	6/20 (30%)
		C2H2 Zn finger	144..165	CDD:275368	6/20 (30%)
		C2H2 Zn finger	175..195	CDD:275368	5/19 (26%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..247	CDD:275368	3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930