DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and ZBTB48

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001265576.1	Gene:	ZBTB48 / 3104	HGNCID:	4930	Length:	688	Species:	Homo sapiens

Alignment Length:	717	Identity:	150/717 - (20%)
Similarity:	238/717 - (33%)	Gaps:	232/717 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 QEADGKKGFDPQAEQMKIRDFL---AGVTSSKM-----------------TTEQSVFHG-SRSNS 129
            |.|.|:.|..|.|.| .:...:   ||:...::                 :.::...|. ::|..
Human   122 QAAGGQSGLGPPASQ-NVNSHVKEPAGLEEEEVSRTLGLVPRDQEPRGSHSPQRPQLHSPAQSEG 185

  Fly   130 SASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIR 194
            .:|...::|               .:.:..|:|...|:..|        .||.||....::....
Human   186 PSSLCGKLK---------------QALKPCPLEDKKPEDCK--------VPPRPLEAEGAQLQGG 227

  Fly   195 ENQVRLRRYIKDEMKYD-------------------------------LATGIESSRKNAAKGPN 228
            .|:..:...::|:...|                               ||.....:||..|. |.
Human   228 SNEWEVVVQVEDDGDGDYMSEPEAVLTRRKSNVIRKPCAAEPALSAGSLAAEPAENRKGTAV-PV 291

  Fly   229 ECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRH 293
            ||..|.:||:....|..|..||        |.|:|           .:|..||:.::.     :.
Human   292 ECPTCHKKFLSKYYLKVHNRKH--------TGEKP-----------FECPKCGKCYFR-----KE 332

  Fly   294 GLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGS 358
            .|:.....:.|          ||::                                       .
Human   333 NLLEHEARNCM----------NRSE---------------------------------------Q 348

  Fly   359 VLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNV 423
            |..|..|:..|....||.||..||..|..::|::|..|....|:...|.    |.:..|
Human   349 VFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCSQQFMQKKDLQSHM----IKLHGA------ 403

  Fly   424 TLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEE 488
              .:...|..|...|.:...||.|..        ....|:||.: |:.|.......:....|.:.
Human   404 --PKPHACPTCAKCFLSRTELQLHEA--------FKHRGEKLFV-CEECGHRASSRNGLQMHIKA 457

  Fly   489 KHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIR 553
            ||.|:               |.::|:.|..::||.::|..|||.|.|.|||.|  ..|.:.|..:
Human   458 KHRNE---------------RPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQC--HLCGKTFRTQ 505

  Fly   554 PDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQH-RLIHRGERRYECEECGKRFYRADALKNHQ 617
            ..|:.| .:.||||||:.|..|.:||.......:| ...|:..|.:.|:.|||.|...:.|:.|.
Human   506 ASLDKH-NRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHV 569

  Fly   618 RIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSR-------------LMMQMQKF---- 665
            |.|.|.:.:.|..|...|    .|..|:|   .|::.:.|             |:::.:|.
Human   570 RRHKGVRKFECTECGYKF----TRQAHLR---RHMEIHDRVENYNPRQRKLRNLIIEDEKMVVVA 627

  Fly   666 -----QLETAAAQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTE----PSVAEMQYSITPEQQ 721
                 :||..:|        |.....:|.|...|.:| |....:.|    |.|.|....||....
Human   628 LQPPAELEVGSA--------EVIVESLAQGGLASQLP-GQRLCAEESFTGPGVLEPSLIITAAVP 683

  Fly   722 EE 723
            |:
Human   684 ED 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	56/197 (28%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	18/50 (36%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..581	CDD:290200	12/25 (48%)
		C2H2 Zn finger	572..592	CDD:275368	5/20 (25%)
		zf-H2C2_2	585..609	CDD:290200	8/24 (33%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	8/24 (33%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
ZBTB48	NP_001265576.1	BTB	16..119	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..140		7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..192		3/30 (10%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
		zf-H2C2_2	305..328	CDD:316026	10/41 (24%)
		C2H2 Zn finger	321..372	CDD:275368	15/104 (14%)
		SFP1	<374..459	CDD:227516	20/105 (19%)
		C2H2 Zn finger	380..401	CDD:275368	6/24 (25%)
		C2H2 Zn finger	409..425	CDD:275370	5/15 (33%)
		C2H2 Zn finger	438..459	CDD:275368	3/20 (15%)
		COG5048	<464..612	CDD:227381	49/157 (31%)
		C2H2 Zn finger	467..487	CDD:275368	8/19 (42%)
		C2H2 Zn finger	495..515	CDD:275368	5/22 (23%)
		C2H2 Zn finger	523..540	CDD:275368	4/16 (25%)
		C2H2 Zn finger	555..572	CDD:275368	7/16 (44%)
		C2H2 Zn finger	580..600	CDD:275368	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100