DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Zfp438

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_017456046.1	Gene:	Zfp438 / 307024	RGDID:	1307214	Length:	800	Species:	Rattus norvegicus

Alignment Length:	766	Identity:	151/766 - (19%)
Similarity:	252/766 - (32%)	Gaps:	214/766 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 AGVTSSKMTTEQSVFHGSRSNSSASTV----------NRI-KCPTCLVQFDAVAF---------Q 152
            :|.|.|..|        |:|.|...|:          :|: .||:.|....::|.         |
  Rat    22 SGTTQSGKT--------SQSKSQFRTIAPKIVPKVLPSRVLPCPSSLSDQGSLALMSKPLGMHTQ 78

  Fly   153 NHSC------EAKPIEVAVPQ--QEKPHLVPTVSAP-----PAPLSKPASERVIRENQVRLRRYI 204
            |::.      |.....||:|.  ..:|...|.:|..     |.|..:|.|.:.:|:
  Rat    79 NYALMQVAGQEGTFSLVALPNVASAQPVQKPRMSIHENLKLPIPRYQPLSSKGLRK--------- 134

  Fly   205 KDEMKYDLATGIESSRKNAAKG-PNECTMCDRKFVHASGLVR-HME--------KHALDLIPSQT 259
                |:||     ||.|..::. |....:|     |.|...: |.|        |....|.||.|
  Rat   135 ----KHDL-----SSPKGGSRDPPGPAQLC-----HLSPSPQAHPELLHKPSPWKRMPTLNPSPT 185

  Fly   260 SEQPHTIPAA---GLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNE 321
            :....|:.:|   |....::.:|||.: ..|.:.     .:.:|:|:.:..|.:...:..|
  Rat   186 NINTATVTSAIGQGDLSPLETDSCGDL-EPPAIP-----AYSTENSSPQSLPASMQKAGCA---- 240

  Fly   322 LLLDGEMLIDNDPAFATSN-QNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAE 385
                 .......||.|:.. |....|...:.||.:       :....:..|...:|..|.....|
  Rat   241 -----RKETPTKPAVASEELQEQVAPAHSVVSSTV-------QSVSVVTKDKLPILPSSRVKTTE 293

  Fly   386 --------RRFECTACDIQMNTAKEASI----HFQTDCIFMREAIRSLNVTLSRYFVCNVCELKF 438
                    ...|.::...:.|..:..||    ...|:......|:.....:..:...|.|.:|
  Rat   294 VVKVEPDAENAESSSSGCRANCEERLSITEGFDAATEIANKTPALHGSKQSACKSAFCPVTKL-- 356

  Fly   439 ANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDF---------CDVNFEFAHDFLAHSEEKHLNK- 493
               ||.::.:.:|     .:...|:|..:|.|.         |.:.      ....|.|:..|.
  Rat   357 ---DLNRKAKPSS-----GVKRRGRKWKVPDDILALQGKRRRCIIG------MCGDSIERARNNP 407

  Fly   494 -KKREKETRNTGAGRIRQY-------------LCDICGKSYTQS---SHLWQHLRFHQGVKPFVC 541
             :.|:::.|.|.    |:|             |..:...:...|   |.|.|.: .:..:.|...
  Rat   408 PEPRDQKPRATS----RKYRSIMPKPVIVLSALAPLASPAAMLSQAPSGLGQDV-LNNALPPKCL 467

  Fly   542 QEENCDRKFTIRPDLNDHIRKCHTG-ERP-YLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECG 604
            ..:..|   .:.|..:..:|...:| ::| ::|.||...|........|...|...|.|.|..|.
  Rat   468 SSKQSD---NLAPKPSSALRNGFSGIKKPWHMCPVCNYHFQFKHHLLDHMNTHTNRRPYSCGICR 529

  Fly   605 KRFYRADALKNHQRIHTGE----KPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKF 665
            |.:.|..:|..|.::|.|:    |...|.||.|.|       .|:|....||....|:::
  Rat   530 KTYVRPGSLSAHMKLHHGDNRPKKLVCCEFCAKVF-------GHVRVYFGHLKEVHRVVI----- 582

  Fly   666 QLETAAAQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTEPSVAEMQYSITPEQQEEMVCVPID 730
            ..|...::......|:.:|.|          ||..|     |. :.::.......:|:.:....|
  Rat   583 STEPTPSELQSEDTPKNKDRD----------PSMQG-----PD-SSLERETKSSLEEDFLLNQAD 631

  Fly   731 EVN------------NSF--FMSHYMQAVPMEEDGSGQHIIVFEQPGQNMD 767
            ||.            .||  ...|.:.....|..|..|.:   .|||...|
  Rat   632 EVKLQIRCGRCQITAQSFAEIKFHLLHVHGEEIQGRLQEV---GQPGSRTD 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/28 (18%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	48/229 (21%)
		C2H2 Zn finger	469..490	CDD:275368	4/29 (14%)
		zf-C2H2	511..533	CDD:278523	6/37 (16%)
		C2H2 Zn finger	513..564	CDD:275368	8/53 (15%)
		C2H2 Zn finger	541..561	CDD:275368	2/19 (11%)
		zf-H2C2_2	555..581	CDD:290200	7/27 (26%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	585..609	CDD:290200	7/23 (30%)
		zf-C2H2	598..620	CDD:278523	7/21 (33%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:290200	10/28 (36%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
Zfp438	XP_017456046.1	C2H2 Zn finger	497..517	CDD:275368	5/19 (26%)
		zf-H2C2_2	509..534	CDD:290200	7/24 (29%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		C2H2 Zn finger	557..575	CDD:275368	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100