DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and Glis1

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_006238623.1	Gene:	Glis1 / 298732	RGDID:	1308030	Length:	793	Species:	Rattus norvegicus

Alignment Length:	366	Identity:	87/366 - (23%)
Similarity:	134/366 - (36%)	Gaps:	95/366 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 CDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGV 536
            |...:|...:.:.|.|:.|::::|.|..| ...||.:|:|      |.:.....|..|:|.|.|.
  Rat   377 CCAAYEQQEELVRHIEKSHIDQRKGEDFT-CFWAGCVRRY------KPFNARYKLLIHMRVHSGE 434

  Fly   537 KPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECE 601
            ||..|..|.|.:.|:...:|..|:|. ||||:||||              ||            .
  Rat   435 KPNKCMFEGCSKAFSRLENLKIHLRS-HTGEKPYLC--------------QH------------P 472

  Fly   602 ECGKRFYRADALKNHQRIHTGEKPYSCLF--CTKTFRQRGDRDKHIRAR-----------HSHLD 653
            .|.|.|..:.....|||.|...|||:|..  |:|.:.......||::|.           |:..|
  Rat   473 GCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHTGAD 537

  Fly   654 ANSRLM---MQMQKFQLET---AAAQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTEPSVAEM 712
            ..:.::   :.:|:.|..|   |:..|......::....|..|:.|......||.:|....|...
  Rat   538 PEAAVLSECLALQQLQASTPLPASRGKGSQTLSQELLPGVYPGSVTPQNGLASGILSPSHDVPSR 602

  Fly   713 QYSITPEQQEEMVCVPIDEVNNSFFMSHYMQAVPMEE---DGSGQHIIVFEQPGQNMDMMSIYDQ 774
            .:             |::....|   .|::..:|..|   ||.|        ||....|:|
  Rat   603 HH-------------PLEVTTGS---HHHLSPLPTAESTRDGLG--------PGLLSPMVS---- 639

  Fly   775 QQVGEPMHESGVPKRPAEENAR------VVVVKNNPTKPIF 809
                 |:...|.|..|....::      ...:.:.||.|.|
  Rat   640 -----PLKGLGPPPLPPASQSQSPGAQSFSTIPSKPTYPPF 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368
		COG5048	<450..647	CDD:227381	52/176 (30%)
		C2H2 Zn finger	469..490	CDD:275368	4/17 (24%)
		zf-C2H2	511..533	CDD:278523	5/21 (24%)
		C2H2 Zn finger	513..564	CDD:275368	15/50 (30%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	11/25 (44%)
		C2H2 Zn finger	572..592	CDD:275368	3/19 (16%)
		zf-H2C2_2	585..609	CDD:290200	5/23 (22%)
		zf-C2H2	598..620	CDD:278523	6/21 (29%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:290200	10/26 (38%)
		C2H2 Zn finger	628..646	CDD:275368	5/19 (26%)
Glis1	XP_006238623.1	C2H2 Zn finger	376..395	CDD:275368	4/17 (24%)
		C2H2 Zn finger	406..431	CDD:275368	8/30 (27%)
		COG5048	435..>514	CDD:227381	32/105 (30%)
		C2H2 Zn finger	439..461	CDD:275368	7/22 (32%)
		zf-H2C2_2	453..480	CDD:290200	16/53 (30%)
		C2H2 Zn finger	469..491	CDD:275368	9/47 (19%)
		C2H2 Zn finger	499..521	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910