DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Zfp212

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_006236507.1	Gene:	Zfp212 / 297066	RGDID:	1307836	Length:	492	Species:	Rattus norvegicus

Alignment Length:	174	Identity:	52/174 - (29%)
Similarity:	71/174 - (40%)	Gaps:	28/174 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 CDFCDVNFEFAHDFLAHSE-------------EKHLNKKKREKETRNTGAGRIRQYLCDICGKSY 520
            |..|.::|.:.....||.:             |:.|..:.|.|..    |.|.:.:.||:|.:|:
  Rat   315 CSECQISFRYKQQLTAHLQSHTSRESYSATEPEESLRPRPRLKPQ----AKRSKLHQCDVCHRSF 375

  Fly   521 TQSSHLWQHLRFHQGVKPFV---CQEENCDRKFTIRPDLNDHI--RKCHTGERPYLCLVCGKRFL 580
            :....|..|.|.||...|..   .||..........|   .||  ||..:.   .:|..|||.|.
  Rat   376 SCKVSLVTHQRCHQQEGPSTSPQIQERFSPNSLVALP---GHIPWRKSRSS---LICGYCGKSFS 434

  Fly   581 TGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEK 624
            ..|...:|:.||.|||.|.|.||.|.|.:...|..||:||..|:
  Rat   435 HPSDLVRHQRIHTGERPYSCPECEKSFVQKQHLLQHQKIHQRER 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368
		COG5048	<450..647	CDD:227381	52/174 (30%)
		C2H2 Zn finger	469..490	CDD:275368	6/33 (18%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	17/55 (31%)
		C2H2 Zn finger	541..561	CDD:275368	5/21 (24%)
		zf-H2C2_2	555..581	CDD:290200	9/27 (33%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	12/23 (52%)
		zf-C2H2	598..620	CDD:278523	9/21 (43%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	6/13 (46%)
		C2H2 Zn finger	628..646	CDD:275368
Zfp212	XP_006236507.1	KRAB_A-box	142..180	CDD:143639
		zf-C2H2	313..335	CDD:278523	5/19 (26%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		COG5048	<329..>474	CDD:227381	46/154 (30%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..446	CDD:275368	7/19 (37%)
		zf-C2H2	426..446	CDD:278523	7/19 (37%)
		zf-H2C2_2	438..463	CDD:290200	12/24 (50%)
		C2H2 Zn finger	454..474	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100