Protein Alignment topi and GLI3

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_000159.3
• Gene: GLI3 / 2737
• HGNCID: 4319
• Length: 1580
• Species: Homo sapiens
• Alignment Length: 227
• Identity: 41/227 - (18%)
• Similarity: 72/227 - (31%)
• Gaps: 71/227 - (31%)

  Fly   283 EFVRMRGP---QGK-------------------GYAEMAVARVPNCGYETPLTENPIDFSEL--- 322
            |.:|:|||   .|:                   .|:..||.|.|..|....|.:.|.....|
Human   536 EQMRLRGPSLHHGRPHLGSVPDFRFSVADGHVDAYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQ 600

  Fly   323 -------AGVEQSLGKRRMSETNLAGG----TRMFPSRSIATPSHSSRGR----RWQSEADTVN- 371
                   |.|..::.:...|:.:::.|    ..:..|..:.:||..:..:    ..|.:.|.:|
Human   601 DWERAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADAQTLAMMLQEQLDAINK 665

  Fly   372 ---------QYPEVEGSNIDDELDEGPTNKLWSMRGFAQV--------------WHGLREKKRAE 413
                     :..|.....|:..:..|..:.|...|..:.:              ..|....:|..
Human   666 EIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLAGSSPPGSGRSTPRRVP 730

  Fly   414 CTPLNAF--LTYVTLPWNSILNDLLSERQKRP 443
            .:|....  |..:|||     :||...|::.|
Human   731 HSPAREVDRLGVMTLP-----SDLRKHRRQLP 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370
		C2H2 Zn finger	277..297	CDD:275370	7/35 (20%)
		C2H2 Zn finger	431..453	CDD:275368	4/13 (31%)
		COG5048	<450..647	CDD:227381
		C2H2 Zn finger	469..490	CDD:275368
		C2H2 Zn finger	513..564	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368
		C2H2 Zn finger	572..592	CDD:275368
		C2H2 Zn finger	600..620	CDD:275368
		zf-H2C2_2	612..637	CDD:463886
		C2H2 Zn finger	628..646	CDD:275368
GLI3	NP_000159.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..475
		SFP1	<542..632	CDD:227516	16/89 (18%)
		C2H2 Zn finger	548..570	CDD:275368	1/21 (5%)
		C2H2 Zn finger	578..601	CDD:275368	5/22 (23%)
		C2H2 Zn finger	609..630	CDD:275368	3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	620..728		14/107 (13%)
		Mediates interaction with DZIP1. /evidence=ECO:0000250|UniProtKB:Q61602	745..845		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..918
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	981..1042