DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Zbtb11

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_766614.2	Gene:	Zbtb11 / 271377	MGIID:	2443876	Length:	1050	Species:	Mus musculus

Alignment Length:	804	Identity:	172/804 - (21%)
Similarity:	281/804 - (34%)	Gaps:	224/804 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VSGEYTLAEIEVELDQQLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPMPTD 69
            |:||...||...|.:||..|.         |:.|:..               :|.|...:|.|..
Mouse   366 VNGELPEAEQNGEPEQQPAPQ---------ASPEAEA---------------SVSPVEGIPEPHP 406

  Fly    70 VVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNS----- 129
            .:...:||             |:...|::...:....:|.|  ....::::|.:.|:.:|
Mouse   407 EMGTASLA-------------KESNQPESAVTREDGIVASV--HPKISKENVTNASQEDSDTGND 456

  Fly   130 -SASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVI 193
             |...:....||            :||  ..|   ..|.:::..|........:..........:
Mouse   457 TSPEDIGAKDCP------------DHS--QSP---GQPSKDEDTLTEATEKTDSGPDDDTYRSRL 504

  Fly   194 RENQVRLRRYIKDEMKYDLATGIESS-RKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPS 257
            |:..|....||:      |..|:|.. :|..|...:......:|.|.....::..::.|.:
Mouse   505 RQRSVNEGGYIR------LHKGMEKKLQKRKAISKSAVQQVAQKLVQRGKKMKQPKRDAKE---- 559

  Fly   258 QTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNEL 322
            .|.|..|           ||..||.:| ..:.||   ::|..:|...|.   .:.|..:..|...
Mouse   560 STEETAH-----------KCGECGMVF-PRRYAF---IMHTLKHERARD---YKCPLCKKQFQYS 606

  Fly   323 LLDGEMLIDND----PAFATSNQNTNP----------PKKEMFSSLILGSVLQCEFCEYIFADIA 373
            ......||.:.    |..::||..:..          .|:|..          |..|......:.
Mouse   607 ASLRAHLIRHTRKEAPTSSSSNSTSTEASGGSSEKGRTKREFI----------CSICGRTLPKLY 661

  Fly   374 ELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKF 438
            .|.:|...|...:...|..|...........:|            :||:.: .:.|.|.:|...|
Mouse   662 SLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLH------------QSLHQS-QKQFQCELCVKSF 713

  Fly   439 ANTDLLQEHRCTSFH-----YFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREK 498
            .....||||  .|.|     ||             |..|..:|......     .|||.|.:.:.
Mouse   714 VTKRSLQEH--MSIHTGESKYF-------------CSICGKSFHRGSGL-----SKHLKKHQPKP 758

  Fly   499 ETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKC 563
            |        :|.|.|..|.||:.::..|.||:..|.|||||.||  .||:.::.:.|...|: |.
Mouse   759 E--------VRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQ--FCDKCYSWKKDWYSHV-KS 812

  Fly   564 HTGERPYLCLVCGKRFLTGSVFYQH--RLIH----RGERRYE--CEECGKRF-----YR------ 609
            |:...||.|.:|||.|...::|.:|  :..|    |.::..|  |::||::|     ||
Mouse   813 HSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCDQCGRKFTQLREYRRHMNNH 877

  Fly   610 ---------------ADA--LKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSR 657
                           |||  ||.|.|.||||:||.|..|::.:.......||:...|... ...:
Mouse   878 EGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDY-VPCK 941

  Fly   658 LMMQMQKFQLE-------------TAAAQKAQSHNPEQQDNDVAGG---------ASTSDVPSGS 700
            :|::....|..             ||..|:.:|..|::.:..|..|         |:|.:.||.|
Mouse   942 IMLEKDTLQFHNQGTQVEHAVSILTADMQEQESSGPQELETVVVTGETMEVLEAVAATEECPSVS 1006

  Fly   701 GFMSTEPSVAEMQYSITPEQQEEM 724
             .:|.:..:..:.|.:..:|.:::
Mouse  1007 -TLSDQSIMQVVNYVLAQQQGQKL 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	2/19 (11%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..453	CDD:275368	8/21 (38%)
		COG5048	<450..647	CDD:227381	70/237 (30%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	20/50 (40%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	11/25 (44%)
		C2H2 Zn finger	572..592	CDD:275368	7/21 (33%)
		zf-H2C2_2	585..609	CDD:290200	9/36 (25%)
		zf-C2H2	598..620	CDD:278523	14/51 (27%)
		C2H2 Zn finger	600..620	CDD:275368	13/47 (28%)
		zf-H2C2_2	612..637	CDD:290200	13/26 (50%)
		C2H2 Zn finger	628..646	CDD:275368	4/17 (24%)
Zbtb11	NP_766614.2	Integrase_H2C2	68..120	CDD:375431
		BTB_POZ_ZBTB11	195..312	CDD:349511
		Trypan_PARP	<367..>421	CDD:392002	17/90 (19%)
		C2H2 Zn finger	568..588	CDD:275368	7/23 (30%)
		C2H2 Zn finger	596..616	CDD:275368	4/19 (21%)
		C2H2 Zn finger	650..670	CDD:275368	4/19 (21%)
		COG5048	<664..837	CDD:227381	58/216 (27%)
		C2H2 Zn finger	678..698	CDD:275368	4/31 (13%)
		C2H2 Zn finger	706..726	CDD:275368	8/21 (38%)
		C2H2 Zn finger	734..754	CDD:275368	6/24 (25%)
		C2H2 Zn finger	765..785	CDD:275368	7/19 (37%)
		C2H2 Zn finger	793..813	CDD:275368	7/22 (32%)
		C2H2 Zn finger	857..877	CDD:275368	6/19 (32%)
		C2H2 Zn finger	885..905	CDD:275368	7/19 (37%)
		zf-H2C2_2	897..920	CDD:372612	12/22 (55%)
		C2H2 Zn finger	913..934	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910