DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Zfp933

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_941021.1	Gene:	Zfp933 / 242747	MGIID:	1922865	Length:	468	Species:	Mus musculus

Alignment Length:	462	Identity:	117/462 - (25%)
Similarity:	155/462 - (33%)	Gaps:	177/462 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 KNAAKG--PNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRI 283
            |..|.|  |.||..|.:.|.:.|.|.||...|        |.|:|:           |||.|.:.
Mouse   122 KRIAIGEKPYECNQCGKAFTYHSQLRRHKRTH--------TGEKPY-----------KCNQCDKA 167

  Fly   284 FYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKK 348
            |...    .|.:||...|:                       ||
Mouse   168 FSQN----GHLIIHKRTHT-----------------------GE--------------------- 184

  Fly   349 EMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACD------IQMNTAKEASIHF 407
                     ...:|..|...|.|.::|.:|..:|..|:.::|..||      |.:...|.|.
Mouse   185 ---------KPYECNQCGKAFTDQSQLRIHKRAHTGEKPYKCNQCDKAFLQNINLRIHKRAH--- 237

  Fly   408 QTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFC 472
                            |..:.:.||.|:..||....|..|:.|
Mouse   238 ----------------TGEKPYKCNQCDKAFAQNGHLIIHKRT---------------------- 264

  Fly   473 DVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVK 537
                        |:.||                    .|.|:.|||::...|.|..|.|.|.|.|
Mouse   265 ------------HTGEK--------------------PYECNQCGKAFADQSQLRIHRRIHTGEK 297

  Fly   538 PFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEE 602
            |:.|.:  ||:.|....:|..| ::.||||:||.|..|.|.||.......|:..|.||:.|||.:
Mouse   298 PYKCNQ--CDKAFAQHSNLRIH-KRTHTGEKPYECNQCDKAFLQNINLKIHKRAHTGEKSYECSQ 359

  Fly   603 CGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIR-----------------ARHS 650
            |||.|.|...|:.|:||||.||||.|..|.|.|.|......|.|                 |.:|
Mouse   360 CGKAFARYYHLQCHERIHTEEKPYKCNQCDKVFSQSHSLQIHKRTHTGEKPYVCNQCGKAFADNS 424

  Fly   651 HLDANSR 657
            ||..:.|
Mouse   425 HLRRHKR 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	8/21 (38%)
		COG5048	<450..647	CDD:227381	63/213 (30%)
		C2H2 Zn finger	469..490	CDD:275368	2/20 (10%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	18/50 (36%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	12/25 (48%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	11/23 (48%)
		zf-C2H2	598..620	CDD:278523	11/21 (52%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	14/24 (58%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
Zfp933	NP_941021.1	KRAB	4..>45	CDD:214630
		KRAB	4..40	CDD:279668
		C2H2 Zn finger	109..125	CDD:275368	1/2 (50%)
		C2H2 Zn finger	133..153	CDD:275368	7/19 (37%)
		zf-H2C2_2	146..170	CDD:290200	12/42 (29%)
		COG5048	157..>467	CDD:227381	102/419 (24%)
		C2H2 Zn finger	161..181	CDD:275368	7/23 (30%)
		zf-H2C2_2	173..197	CDD:290200	8/76 (11%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		zf-H2C2_2	202..226	CDD:290200	7/23 (30%)
		C2H2 Zn finger	217..237	CDD:275368	5/19 (26%)
		zf-H2C2_2	229..254	CDD:290200	7/43 (16%)
		C2H2 Zn finger	245..265	CDD:275368	8/53 (15%)
		zf-H2C2_2	257..281	CDD:290200	11/77 (14%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..310	CDD:290200	11/25 (44%)
		C2H2 Zn finger	301..321	CDD:275368	6/22 (27%)
		zf-H2C2_2	313..338	CDD:290200	12/25 (48%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		zf-H2C2_2	341..366	CDD:290200	11/24 (46%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	14/24 (58%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..421	CDD:290200	2/23 (9%)
		C2H2 Zn finger	413..433	CDD:275368	5/19 (26%)
		zf-H2C2_2	425..450	CDD:290200	3/7 (43%)
		C2H2 Zn finger	441..461	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100