DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and Zscan2

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001369440.1	Gene:	Zscan2 / 22691	MGIID:	99176	Length:	614	Species:	Mus musculus

Alignment Length:	603	Identity:	150/603 - (24%)
Similarity:	219/603 - (36%)	Gaps:	155/603 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 QILQEADGKKGFDPQAE--QMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQ 145
            |..:.:|    |:.|:|  :....|...||.|..|....|...|.:.:...|...|
Mouse   129 QTFRHSD----FEIQSENGENSNEDMFEGVESHGMFLNISGGEGGQQSDGDSDFER--------- 180

  Fly   146 FDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPL---------SKP------------AS 189
                     .|.:...:...| .|.|.:||:.......|         .||            .|
Mouse   181 ---------DCGSGGAQGHAP-GEDPRVVPSEGREVGQLIGLQGTYLGEKPYECPQCGKTFSRKS 235

  Fly   190 ERVIRENQVRLRRYIK-DEMKYDLATGIESSR---KNAAKGPNECTMCDRKFVHASGLVRHMEKH 250
            ..:..|......:|.| ||.....:.|...||   .:..:.|.:|..|.:.|..::.|:.|...|
Mouse   236 HLITHERTHTGEKYYKCDECGKSFSDGSNFSRHQTTHTGEKPYKCRDCGKSFSRSANLITHQRIH 300

  Fly   251 ALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVP-- 313
                    |.|:|           .:|..||:.|........|...|..|      .|.: .|
Mouse   301 --------TGEKP-----------FQCAECGKSFSRSPNLIAHQRTHTGE------KPYS-CPEC 339

  Fly   314 ----SNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAE 374
                .||:..|                  ::|..:..:|.          ..|:.|...|:..:.
Mouse   340 GKSFGNRSSLN------------------THQGIHTGEKP----------YACKECGESFSYNSN 376

  Fly   375 LLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFA 439
            |:.|...|..|:.::||.|..:.:.:.....|.:|.             |..:.:.|..|...|:
Mouse   377 LIRHQRIHTGEKPYKCTECGQKFSQSSALITHRRTH-------------TGEKPYQCGECGKNFS 428

  Fly   440 NTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTG 504
            .:..|..||.|      .|.|...|    |..|..:|..:...:||               :.|.
Mouse   429 RSSNLATHRRT------HLVEKPYK----CGLCGKSFSQSSSLIAH---------------QGTH 468

  Fly   505 AGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERP 569
            .|. :.|.|..||:|::.||:|.:|.|.|.|.||:.|.:  |.:.|:.|..|..| ::.||||:|
Mouse   469 TGE-KPYECLTCGESFSWSSNLIKHQRTHTGEKPYRCGD--CGKGFSQRSQLVVH-QRTHTGEKP 529

  Fly   570 YLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKT 634
            |.||:|||.|..||:...|:..|.|::.|.|.||||.|.....|..|||||||||||.|..|.|.
Mouse   530 YKCLMCGKSFSRGSILVMHQRAHLGDKPYRCPECGKGFSWNSVLIIHQRIHTGEKPYRCPECGKG 594

  Fly   635 FRQRGDRDKHIRARHSHL 652
            |....:...|.|   :||
Mouse   595 FSNSSNFITHQR---THL 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	7/21 (33%)
		COG5048	<450..647	CDD:227381	72/196 (37%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	10/21 (48%)
		C2H2 Zn finger	513..564	CDD:275368	19/50 (38%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	14/25 (56%)
		C2H2 Zn finger	572..592	CDD:275368	9/19 (47%)
		zf-H2C2_2	585..609	CDD:290200	10/23 (43%)
		zf-C2H2	598..620	CDD:278523	11/21 (52%)
		C2H2 Zn finger	600..620	CDD:275368	10/19 (53%)
		zf-H2C2_2	612..637	CDD:290200	16/24 (67%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
Zscan2	NP_001369440.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..73
		SCAN	69..131	CDD:396558	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..200		8/56 (14%)
		COG5048	220..600	CDD:227381	125/475 (26%)
		C2H2 Zn finger	224..244	CDD:275368	2/19 (11%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		C2H2 Zn finger	280..300	CDD:275368	5/19 (26%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		C2H2 Zn finger	336..356	CDD:275368	5/37 (14%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		C2H2 Zn finger	392..412	CDD:275368	4/19 (21%)
		C2H2 Zn finger	420..440	CDD:275368	7/25 (28%)
		C2H2 Zn finger	448..468	CDD:275368	5/34 (15%)
		C2H2 Zn finger	476..496	CDD:275368	9/19 (47%)
		C2H2 Zn finger	504..524	CDD:275368	6/22 (27%)
		C2H2 Zn finger	532..552	CDD:275368	9/19 (47%)
		C2H2 Zn finger	560..580	CDD:275368	10/19 (53%)
		C2H2 Zn finger	588..608	CDD:275368	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910