DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and E4F1

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_005255212.1	Gene:	E4F1 / 1877	HGNCID:	3121	Length:	837	Species:	Homo sapiens

Alignment Length:	879	Identity:	187/879 - (21%)
Similarity:	302/879 - (34%)	Gaps:	246/879 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKVKVSGEYTLAEIEVELDQQLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALP 65
            |.|:|:..:| ||.:.|                 |..|:..|....|:       .|:.|:|.|.
Human     5 MAVRVTAAHT-AEAQAE-----------------AGREAGEGAVAAVA-------AALAPSGFLG 44

  Fly    66 MPTDVVVERTLADPAFKQILQEADGKKGFDP-QAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNS 129
            :|.....|...|||      :.|.|.:...| .||....|  .||.|........:...|....|
Human    45 LPAPFSEEGNRADP------EGAAGVRAVHPGLAEARMAR--AAGSTDPPRPRHLADLAGPSQPS 101

  Fly   130 S----ASTVNRIKCPTCLVQFDAVA-FQNH----SCEAKPIEV-----------------AVPQQ 168
            :    ...|:|  |..|..:|.|:. |..|    :|:..|.|.                 |.|..
Human   102 TKPPDEDDVHR--CGRCQAEFTALEDFVQHKIQKACQRAPPEALPATPATTALLGQEVVPAAPGP 164

  Fly   169 EKP----HLVPTVSAPPAPLSKPASERV----IRE------------------------------ 195
            |:|    |:|...::..|.:|. ||:.|    |:|
Human   165 EEPITVAHIVVEAASLAADISH-ASDLVGGGHIKEVIVAAEAELGDGEMAEAPGSPRQQGLGLAG 228

  Fly   196 --NQVRLRRYIKDEMKYDLA-------TG--------IESSRKNAAKGPNECTMCDRKFVHASGL 243
              .|.:::..:..:.:|..|       ||        ..||||:     :||.:|...|.....|
Human   229 EGEQAQVKLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRKD-----HECKLCGASFRTKGSL 288

  Fly   244 VRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSP 308
            :||..:|        |.|:|:           ||:.||:.|.:.....||         ....:|
Human   289 IRHHRRH--------TDERPY-----------KCSKCGKSFRESGALTRH---------LKSLTP 325

  Fly   309 MTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIA 373
            .|:    :..|:   :..::::..:.|.|.|  ..........:|.:.|..::.....::..|..
Human   326 CTE----KIRFS---VSKDVVVSKEDARAGS--GAGAAGLGTATSSVTGEPIETSPVIHLVTDAK 381

  Fly   374 ELLVHSASHVAERRFECTACDIQMNT-AKEASIHFQTDCI-------FMREAIRSLNVTLSRY-- 428
            ..::|.. ||     :.....:.|.. |.|..:..:..|.       .:.:|:::..:.|.|.
Human   382 GTVIHEV-HV-----QMQELSLGMKALAPEPPVSQELPCSSEGSRENLLHQAMQNSGIVLERAAG 440

  Fly   429 -----------------FVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNF 476
                             ......:|.......|:....:.....||.:        ||..|...|
Human   441 EEGALEPAPAAGSSPQPLAVAAPQLPVLEVQPLETQVASEASAVPRTH--------PCPQCSETF 497

  Fly   477 EFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVC 541
            ..|....||         ||    .:||.   |.:.|..|||::.::..|.:|...|...:.|.|
Human   498 PTAATLEAH---------KR----GHTGP---RPFACAQCGKAFPKAYLLKKHQEVHVRERRFRC 546

  Fly   542 QEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKR 606
            .:  |.:.:.....:..| |:.|:.||||.|..||||:.|.:....|...|..|:.:.|:.|.:.
Human   547 GD--CGKLYKTIAHVRGH-RRVHSDERPYPCPKCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRG 608

  Fly   607 FYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAA 671
            |....:|..|.|.||||||:.|..|.:.|.:.|..::|:|.:...|.....|::.    :...||
Human   609 FREKGSLVRHVRHHTGEKPFKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVS----EDSPAA 669

  Fly   672 AQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTEPSVAEMQYSITPEQQEEMVCVPIDEVNNSF 736
            |....:.:|.           |..|...|....|:..:.|    .|.:..|......|.|...:.
Human   670 ATTVLTEDPH-----------TVLVEFSSVVADTQEYIIE----ATADDAETSEATEIIEGTQTE 719

  Fly   737 FMSHYMQAVP--MEEDGSGQHIIVFEQPGQNMDM 768
            ..||.|:.|.  :.:..:|..|||     ||:.|
Human   720 VDSHIMKVVQQIVHQASAGHQIIV-----QNVTM 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..453	CDD:275368	2/21 (10%)
		COG5048	<450..647	CDD:227381	57/196 (29%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		zf-C2H2	511..533	CDD:278523	6/21 (29%)
		C2H2 Zn finger	513..564	CDD:275368	12/50 (24%)
		C2H2 Zn finger	541..561	CDD:275368	3/19 (16%)
		zf-H2C2_2	555..581	CDD:290200	12/25 (48%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	6/23 (26%)
		zf-C2H2	598..620	CDD:278523	6/21 (29%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:290200	12/24 (50%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
E4F1	XP_005255212.1	COG5048	236..648	CDD:227381	104/486 (21%)
		C2H2 Zn finger	247..267	CDD:275368	3/19 (16%)
		zf-C2H2	273..295	CDD:278523	7/21 (33%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..310	CDD:290200	11/41 (27%)
		zf-C2H2	301..322	CDD:278523	7/40 (18%)
		C2H2 Zn finger	303..321	CDD:275368	6/26 (23%)
		C2H2 Zn finger	490..510	CDD:275368	8/32 (25%)
		DUF45	<506..585	CDD:302795	29/97 (30%)
		C2H2 Zn finger	518..538	CDD:275368	6/19 (32%)
		C2H2 Zn finger	546..566	CDD:275368	4/22 (18%)
		zf-H2C2_2	558..583	CDD:290200	12/25 (48%)
		C2H2 Zn finger	574..594	CDD:275368	7/19 (37%)
		zf-H2C2_2	588..609	CDD:290200	5/20 (25%)
		C2H2 Zn finger	602..622	CDD:275368	6/19 (32%)
		zf-H2C2_2	614..638	CDD:290200	11/23 (48%)
		C2H2 Zn finger	630..649	CDD:275368	5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100