DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and bcl-11

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001122913.1	Gene:	bcl-11 / 179019	WormBaseID:	WBGene00017430	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	799	Identity:	151/799 - (18%)
Similarity:	252/799 - (31%)	Gaps:	242/799 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AEIEVELDQQLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFA----VGPAGA-LPMP---- 67
            ::..::|.::|| ..|...:.:.:::....|:|..|.| :||...|    :...|| .|.|
Worm    44 SDYRLDLKKRLT-TFLTSNSQMASSDSGVSGVESTVEH-DLSELKASDSPMSHDGADSPRPELDR 106

  Fly    68 TDVVV----ERTLADPAFKQILQ----EADGK-----------KGFDPQAEQMKIRDF--LAGVT 111
            ||:||    ..:.:...|...::    ...||           :.||    :.:.|.|  .|.:.
Worm   107 TDIVVCGECHTSFSLSCFSNFIEHKVSNCGGKLTPSDDCEVTPRNFD----RSRRRTFNPAALIR 167

  Fly   112 SSKMTTEQSVFHG------SRSNSSASTVNRIKCPTCLVQF-DAVAFQNHSCEAKPIEV---AVP 166
            ..:.|:..::...      :.:|...|:...:.|..|..:| |......||.:...:.|   |:|
Worm   168 CGRSTSANALLPNYNMDVTTDTNDLGSSSKSLTCCNCKERFGDVWTLLKHSYDIHGLRVCQEAIP 232

  Fly   167 QQEKPHLVPTVSAPPAPLSKPASER-------------VIRENQVRLRRYIKDEMKYDLATGIES 218
            :.:..  |.:.|:|.:..|...|.|             .|:.....:..:..:.:|..:....|.
Worm   233 ESDVS--VTSTSSPTSNESMHMSSRYNHNDTSSKIMHQTIKSESTMMNSFCSERLKEIVTRAGEQ 295

  Fly   219 SRKNAAK----GPNECTMCDR--KFVHASGLVRHMEKHALDLIPS----QTS-------EQPHTI 266
            .:|....    .|:|.|..::  .|...|.|.....:..|..:.|    |||       .||..:
Worm   296 DQKPLMALRRLMPSEETEEEQVSAFTSTSLLNSRASQPQLPTVSSSAGFQTSGSMPNVWMQPSML 360

  Fly   267 PAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLID 331
            .|...:..    |..::.|....:....|::.|.:...:|....|:...:          :.||.
Worm   361 AAMQEYYA----SIQQMPYPMTNSTAVALLNISNNLQQQQQQQQQLQQQQ----------QNLIA 411

  Fly   332 NDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQ 396
            ..|..||...   |....:|.||                                 ...:..|..
Worm   412 AQPQVATPQP---PAPTPLFQSL---------------------------------NRLSTADES 440

  Fly   397 MNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNEN 461
            ..|.:.||:..:      |.|.....:|..|.      .:|....|.|            .:.::
Worm   441 SYTPRPASVAIR------RRASPEEELTPPRK------SMKIEEEDQL------------IVVDD 481

  Fly   462 GKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHL 526
            |:                   ||....:..|..|:|:              |:.|.|.:|..|:|
Worm   482 GE-------------------LAEPAARKPNNIKKER--------------CNFCNKVFTNRSNL 513

  Fly   527 WQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLI 591
            ..|||.|.|.||:.||                   .|     ||.|....|  ||     :|...
Worm   514 IVHLRSHTGEKPYKCQ-------------------LC-----PYACAQSSK--LT-----RHMRT 547

  Fly   592 H--RGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGD-RDKHIRARHSHL- 652
            |  :|:..|.|..|...|.....|:.|.|        .|:..|:..|:.|. .::.||...|.|
Worm   548 HGQQGKETYHCYICRMPFSVHSTLEKHMR--------KCVVSTQGRREGGSPPERSIRPTPSALA 604

  Fly   653 DANSRLMMQMQKF------QLETAAAQKAQSH-------NPEQQDNDVAGGASTSD-VPSGSGFM 703
            :|.|.|.:.....      |..|....::|||       :.....|......|..| :.:.....
Worm   605 EATSLLALSAPSISVPPQPQASTVGQNQSQSHQIVLNWLHALNASNSTPTATSKEDMIEADEDME 669

  Fly   704 STEPSVAEMQYSITPEQQE 722
            .||.|..:....:|.|..:
Worm   670 ETEASDLQSHQPLTSESNQ 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	4/21 (19%)
		C2H2 Zn finger	277..297	CDD:275368	3/19 (16%)
		C2H2 Zn finger	431..453	CDD:275368	3/21 (14%)
		COG5048	<450..647	CDD:227381	43/199 (22%)
		C2H2 Zn finger	469..490	CDD:275368	2/20 (10%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	15/50 (30%)
		C2H2 Zn finger	541..561	CDD:275368	2/19 (11%)
		zf-H2C2_2	555..581	CDD:290200	5/25 (20%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	585..609	CDD:290200	7/25 (28%)
		zf-C2H2	598..620	CDD:278523	7/21 (33%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:290200	5/24 (21%)
		C2H2 Zn finger	628..646	CDD:275368	4/18 (22%)
bcl-11	NP_001122913.1	zf-C2H2	499..520	CDD:278523	9/34 (26%)
		zf-C2H2_2	500..>577	CDD:289522	32/115 (28%)
		C2H2 Zn finger	500..520	CDD:275368	9/19 (47%)
		zf-H2C2_2	512..537	CDD:290200	14/48 (29%)
		C2H2 Zn finger	528..548	CDD:275368	10/50 (20%)
		C2H2 Zn finger	558..576	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100