DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Y111B2A.10

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_499640.1	Gene:	Y111B2A.10 / 176678	WormBaseID:	WBGene00013734	Length:	430	Species:	Caenorhabditis elegans

Alignment Length:	322	Identity:	69/322 - (21%)
Similarity:	114/322 - (35%)	Gaps:	75/322 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 KKEMFSSLI----LGSVLQCEFCEYIFADIAELLVHS--ASHVAERRFECTACDIQMNTAKEASI 405
            |:::..||:    .||:..|..|...|.:...|.:|:  ...::..:..|..|.......|....
Worm   129 KQQLEDSLLKPHTAGSIFTCVMCSKAFPNAEALQIHTDQVHDLSRLKHRCKLCGKAYKRKKNLDA 193

  Fly   406 HFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLL--- 467
            |.   .:.::|            ..|:.|.|.|.:...||.|...  |:    .|:..:|.:
Worm   194 HM---ALHLKE------------IQCDNCSLVFQSEKSLQSHIIR--HH----QEDADELEVWKA 237

  Fly   468 PCDFCDVNFEF----AHDFLAHSEEKHLNKKKREKETR-------------------------NT 503
            ||..|...|..    .|::...:.||.:.|::..|..:                         .|
Worm   238 PCSICKELFPSTSVKTHEWYCKNREKIIEKQRVSKILKVQSLPSSPALSTVSYASFSSCQPGPIT 302

  Fly   504 GAGRIRQYLCDICGKSYTQSSHLWQHL-RFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGE 567
            .....|...|.:||:|:.....:.:|: |.|...|    .:.|......|..:...|
Worm   303 SPVSYRDKSCQVCGESFASRQSMLRHVGRKHPDAK----NDPNVTAVRYISAESPKH-------- 355

  Fly   568 RPYLCLVCGKRFLTGSVFYQHRL-IHRGERRYECEECGKRFYRADALKNH-QRIHTGEKPYS 627
             ||.|:.|||||.|.:....|:. :|....|:||..|.|.:.....|:.| :|:|..:.|.|
Worm   356 -PYACIECGKRFTTVTALSTHKARVHSQSNRFECTICHKSYPVPSELRKHIKRVHEKDAPKS 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368	7/21 (33%)
		COG5048	<450..647	CDD:227381	47/213 (22%)
		C2H2 Zn finger	469..490	CDD:275368	5/24 (21%)
		zf-C2H2	511..533	CDD:278523	6/22 (27%)
		C2H2 Zn finger	513..564	CDD:275368	11/51 (22%)
		C2H2 Zn finger	541..561	CDD:275368	3/19 (16%)
		zf-H2C2_2	555..581	CDD:290200	9/25 (36%)
		C2H2 Zn finger	572..592	CDD:275368	8/20 (40%)
		zf-H2C2_2	585..609	CDD:290200	7/24 (29%)
		zf-C2H2	598..620	CDD:278523	7/22 (32%)
		C2H2 Zn finger	600..620	CDD:275368	6/20 (30%)
		zf-H2C2_2	612..637	CDD:290200	6/17 (35%)
		C2H2 Zn finger	628..646	CDD:275368	69/322 (21%)
Y111B2A.10	NP_499640.1	C2H2 Zn finger	148..169	CDD:275368	5/20 (25%)
		zf-C2H2_8	151..221	CDD:292531	15/84 (18%)
		C2H2 Zn finger	178..198	CDD:275368	4/22 (18%)
		C2H2 Zn finger	204..224	CDD:275368	7/21 (33%)
		C2H2 Zn finger	312..333	CDD:275368	6/20 (30%)
		C2H2 Zn finger	359..380	CDD:275368	8/20 (40%)
		C2H2 Zn finger	388..409	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000