DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and ZNF681

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_612143.2	Gene:	ZNF681 / 148213	HGNCID:	26457	Length:	645	Species:	Homo sapiens

Alignment Length:	619	Identity:	159/619 - (25%)
Similarity:	245/619 - (39%)	Gaps:	159/619 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 AKPIEVAVPQQEKP------HLVPTVSAPPAPLSKPAS----ERVIREN--QVRLRRYIKDEMK- 209
            :||..:...:|||.      |.:  |:.||...|..|.    |:.|:::  :|..|||.|.|.:
Human    48 SKPDLITCLEQEKEPWTRKRHRM--VAEPPVICSHFAQDFSPEQNIKDSFQKVTPRRYGKCEHEN 110

  Fly   210 YDLATGIESSR--KNAAKGPNECT--------MCDR--KFVHA-SGLVRHMEKHALDLIPSQTSE 261
            ..|:..::..:  |....|.|:|.        .||:  |..|. |.|..|..:|        |.:
Human   111 LQLSKSVDECKVQKGGYNGLNQCLPTTQSKIFQCDKYMKIFHKFSNLNGHKVRH--------TRK 167

  Fly   262 QPHTIPAAG----------LHVVV-------KCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQ--- 306
            :|......|          .|.::       ||..||:.|....:..:|..||..|.|.:.:
Human   168 KPFKYKEFGKSFCIFSNLTQHKIICTRVNFYKCEDCGKAFNGSSIFTKHKRIHIGEKSYICEECG 232

  Fly   307 ---SPMTQVPSNRADF-NELLLDGEMLIDNDPAFATSNQNT---------NPPKKE-----MFSS 353
               :..|.:.:::..: .:.|...|   :...||..|:..|         ||.|:|     ...|
Human   233 KACNQFTNLTTHKIIYTRDKLYKRE---ECSKAFNLSSHITTHTIIHTGENPYKREECDKAFNQS 294

  Fly   354 LILGS---------VLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQT 409
            |.|.:         :.:.:.|...|...:.|..|...|..|:.::|..|....|.:...:.|
Human   295 LTLTTHKIIHTREKLNEYKECGKAFNQSSHLTRHKIIHTGEKPYKCEECGKAFNQSSHLTRH--- 356

  Fly   410 DCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLP--CDFC 472
                      .:..|..:.:.|..|...|..:..|..|         ::...|:|   |  |:.|
Human   357 ----------KIIHTGEKPYRCEECGKAFRQSSHLTTH---------KIIHTGEK---PYKCEEC 399

  Fly   473 DVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVK 537
            ...|         ::..||.:.|    :.:||.   :.|.|:.|||:..|||:|.:|...|...|
Human   400 GKAF---------NKSSHLTRHK----SIHTGE---KPYQCEKCGKASNQSSNLTEHKNIHTEEK 448

  Fly   538 PFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEE 602
            |:.|:|  |.:.|....:|..| ::.||||:||.|..|||.|...|:...|:.||.||:.|:|||
Human   449 PYKCEE--CGKAFNQFSNLTTH-KRIHTGEKPYKCEECGKAFNQSSILTTHKRIHTGEKSYKCEE 510

  Fly   603 CGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARH------------------ 649
            |||.|||:..|..|::||||||||:|..|.|.|    :...|: |.|
Human   511 CGKAFYRSSKLTEHKKIHTGEKPYTCEECGKAF----NHSSHL-ATHKVIHTGEKPYQCEECGKA 570

  Fly   650 ----SHLDANSRLMMQMQKFQLETAAAQKAQSHN 679
                |||..:.|:....:.:|.|.......||.|
Human   571 FNQSSHLTRHKRIHTGEKPYQCEKCGKAFNQSSN 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	8/30 (27%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	72/198 (36%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	10/21 (48%)
		C2H2 Zn finger	513..564	CDD:275368	18/50 (36%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	13/23 (57%)
		zf-C2H2	598..620	CDD:278523	12/21 (57%)
		C2H2 Zn finger	600..620	CDD:275368	11/19 (58%)
		zf-H2C2_2	612..637	CDD:290200	14/24 (58%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
ZNF681	NP_612143.2	KRAB	4..64	CDD:214630	5/15 (33%)
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		C2H2 Zn finger	176..192	CDD:275368	2/15 (13%)
		COG5048	198..610	CDD:227381	123/459 (27%)
		C2H2 Zn finger	200..220	CDD:275368	5/19 (26%)
		C2H2 Zn finger	285..304	CDD:275368	4/18 (22%)
		C2H2 Zn finger	313..332	CDD:275368	4/18 (22%)
		zf-H2C2_2	324..349	CDD:290200	6/24 (25%)
		C2H2 Zn finger	340..360	CDD:275368	4/32 (13%)
		zf-H2C2_2	352..377	CDD:290200	5/37 (14%)
		C2H2 Zn finger	368..388	CDD:275368	5/28 (18%)
		zf-H2C2_2	380..404	CDD:290200	8/44 (18%)
		C2H2 Zn finger	396..416	CDD:275368	6/32 (19%)
		C2H2 Zn finger	424..444	CDD:275368	9/19 (47%)
		zf-H2C2_2	436..461	CDD:290200	9/26 (35%)
		C2H2 Zn finger	452..472	CDD:275368	6/22 (27%)
		zf-H2C2_2	464..489	CDD:290200	13/25 (52%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		zf-H2C2_2	493..517	CDD:290200	13/23 (57%)
		C2H2 Zn finger	508..528	CDD:275368	11/19 (58%)
		zf-H2C2_2	521..545	CDD:290200	14/27 (52%)
		C2H2 Zn finger	536..556	CDD:275368	7/24 (29%)
		zf-H2C2_2	548..573	CDD:290200	3/25 (12%)
		C2H2 Zn finger	564..584	CDD:275368	4/19 (21%)
		zf-H2C2_2	576..601	CDD:290200	5/24 (21%)
		C2H2 Zn finger	592..612	CDD:275368	4/13 (31%)
		C2H2 Zn finger	620..638	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	626..645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910