DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and ZNF785

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:XP_011544054.1 Gene:ZNF785 / 146540 HGNCID:26496 Length:418 Species:Homo sapiens


Alignment Length:248 Identity:77/248 - (31%)
Similarity:107/248 - (43%) Gaps:44/248 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   421 LNVTLSRYF--VCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFE-----F 478
            |..||:|..  .|..|...|:...||..|:        |::...:.  ..|..|...|.     .
Human   175 LKDTLTRRLPHSCPDCGRNFSYPSLLASHQ--------RVHSGERP--FSCGQCQARFSQRRYLL 229

  Fly   479 AHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQE 543
            .|.|: |:.||                    .|.|..||:.:.|...|..|.|.|.|.||:.|.:
Human   230 QHQFI-HTGEK--------------------PYPCPDCGRRFRQRGSLAIHRRAHTGEKPYACSD 273

  Fly   544 ENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFY 608
              |..:||....|..|.|| ||||:||.|..|..||...|:...||.||.||:.|.|.:||:||.
Human   274 --CKSRFTYPYLLAIHQRK-HTGEKPYSCPDCSLRFAYTSLLAIHRRIHTGEKPYPCPDCGRRFT 335

  Fly   609 RADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQ 661
            .:..|.:|:|||:..:|:.|:.|.|.|:::...:.|   |..|...:.|...|
Human   336 YSSLLLSHRRIHSDSRPFPCVECGKGFKRKTALEAH---RWIHRSCSERRAWQ 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368 6/21 (29%)
COG5048 <450..647 CDD:227381 63/201 (31%)
C2H2 Zn finger 469..490 CDD:275368 7/25 (28%)
zf-C2H2 511..533 CDD:278523 8/21 (38%)
C2H2 Zn finger 513..564 CDD:275368 19/50 (38%)
C2H2 Zn finger 541..561 CDD:275368 6/19 (32%)
zf-H2C2_2 555..581 CDD:290200 14/25 (56%)
C2H2 Zn finger 572..592 CDD:275368 7/19 (37%)
zf-H2C2_2 585..609 CDD:290200 12/23 (52%)
zf-C2H2 598..620 CDD:278523 9/21 (43%)
C2H2 Zn finger 600..620 CDD:275368 8/19 (42%)
zf-H2C2_2 612..637 CDD:290200 10/24 (42%)
C2H2 Zn finger 628..646 CDD:275368 5/17 (29%)
ZNF785XP_011544054.1 KRAB 29..102 CDD:214630
COG5048 <156..372 CDD:227381 73/233 (31%)
C2H2 Zn finger 187..207 CDD:275368 7/27 (26%)
C2H2 Zn finger 215..235 CDD:275368 5/20 (25%)
C2H2 Zn finger 243..263 CDD:275368 7/19 (37%)
C2H2 Zn finger 271..291 CDD:275368 8/22 (36%)
C2H2 Zn finger 299..319 CDD:275368 7/19 (37%)
C2H2 Zn finger 327..347 CDD:275368 8/19 (42%)
C2H2 Zn finger 355..375 CDD:275368 6/22 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7696
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.860

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