DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and AgaP_AGAP008984

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_319733.4	Gene:	AgaP_AGAP008984 / 1279946	VectorBaseID:	AGAP008984	Length:	1261	Species:	Anopheles gambiae

Alignment Length:	1072	Identity:	220/1072 - (20%)
Similarity:	340/1072 - (31%)	Gaps:	407/1072 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPMPTDVVVERTLADPAFK-QILQ 86
            |||                |.|.:|....:.....:.|...:.|.....:....||...: .|:.
Mosquito     1 TPD----------------GREYLVDERSIQNIDQIPPENLIYMTASEALSVVDADDVGQLAIVD 49

  Fly    87 EADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAF 151
            |:           |:.:.|:.|  ...::|.|                        ::..|.|..
Mosquito    50 ES-----------QLALHDYYA--EECEVTEE------------------------VITDDWVQP 77

  Fly   152 QNHSCEAKPIEVAVPQ--------QEKPHLVPTVSAPPAPLSKP-----ASERVIREN--QVRLR 201
            |...|    ::|.|.|        ||:..:...:......||:|     .|.|..:::  |..|.
Mosquito    78 QGEEC----VQVTVDQLGVSAVVVQEEDDISVPLDQDQYTLSRPYPCDFCSRRFRKKSSLQNHLM 138

  Fly   202 RYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALD-------LIPSQT 259
            .:..|.                   |:.|.:|..::.|.:.|:.|:::||.|       .:.|..
Mosquito   139 AHSNDR-------------------PHCCNLCGAQYSHRADLINHLKQHADDEDMYIQNSMVSYN 184

  Fly   260 SEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSP-MTQVP---SNRADFN 320
            |:.|..:.:...:.....::.|...|          :||   ..|.|.| :..||   ..:....
Mosquito   185 SQPPMQLISTTHYGASSSSTIGSSSY----------VHD---VPMEQPPYLESVPPVLEQKYALG 236

  Fly   321 ELLLDGEMLIDNDPAFAT-------SNQNTNPPK-KEMFSSLILGS------------------- 358
            ::...|...:.|.....|       |.|:|...: |.:|:|. |||
Mosquito   237 KMDPTGPATLSNTTGKRTPRKKQSQSTQDTRTARTKPVFASK-LGSRQIKKEPLEHGEGGNAISS 300

  Fly   359 -------------VLQCEFCEYIFADIAELLVHSASHVAERRFECTACDI-------------QM 397
                         ...|:.|...||....||.|:.:|....|::|..|:.             :.
Mosquito   301 PPPTRTVAADWRKPFVCQQCGASFAREKALLSHARTHAGSTRYDCALCNAHFWEQSLLRDHVQRA 365

  Fly   398 NTAKEA---------SIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFH 453
            :.|:||         |.|...:...:      ...|.::.:.|:.|...|...|.|..|...:..
Mosquito   366 HQAQEAWVADHEPYGSAHGAIELPVV------TTTTTTKQYNCDSCSAVFFQLDHLLNHTHQAHG 424

  Fly   454 YFPRLNENG--------KKLL--------------LPCDFCDVNFEFAHDFLAHSE--------- 487
            .|.:..::.        ::||              |.|..|..:|:.|.|.|.|||
Mosquito   425 TFEQHQQSSSNRSVLVKQELLQTSSKRSNEPDQSALTCRDCGESFDSAMDLLDHSEVHGGGAAQY 489

  Fly   488 ------------------EKHLNKKKREKETRNTGA-------------------GRIRQYLCDI 515
                              ::|:..:.|::.|..:.|                   .|.|.:.|..
Mosquito   490 EPLECQLCGEKFPDEANIKQHVQDRHRDELTATSCAICGKRCKSQTTLMKHAWDHSRERAHSCSK 554

  Fly   516 CGKSYTQSSHLWQHLRFH--QGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKR 578
            |||::...:.|.:|:..|  :.|:..||:||..|.:     .|.:| |..||....|.|..|||.
Mosquito   555 CGKTFHHMTRLKRHMDSHRNKAVRCEVCKEEFPDGR-----TLMNH-RHSHTKSNEYPCHECGKT 613

  Fly   579 FLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDK 643
            |.:.|....|..||.|||.|.|..|.|.|.....|:.|:|||||||||:|..|.|.|.||....:
Mosquito   614 FGSRSSQQIHMRIHTGERPYACRFCWKAFADGGTLRKHERIHTGEKPYACPVCPKAFNQRVVLRE 678

  Fly   644 HIRARHS----------------------------------HLDANSRLMMQMQKFQLETAAAQK 674
            ||||.||                                  |.|.|:.:..:...|..:....:|
Mosquito   679 HIRAHHSQADAKRGSPDQPYYCTVCSSPFGTTADLVQHLIEHSDTNTAMKRKPPTFPRKYKRRRK 743

  Fly   675 AQSH-------------------------NPEQQDNDVAGG----------ASTSD--------- 695
            .:.|                         ..|:.|:|.:||          |.|:|
Mosquito   744 LKPHELERLQSGRRKQKSKRQMDNEEEEEEEEEDDDDGSGGSGNQFEDGTTARTTDRTVVERARG 808

  Fly   696 --VPSGSGFMSTEP------SVAEM--QY------SIT--PE----------------------- 719
              .|:||.|:...|      |..||  :|      |:|  |:
Mosquito   809 DGKPTGSSFVRYHPDGTRKASTREMYLEYDDMGGGSVTHAPKASSQGMLDVNGINLLSNVVLLHG 873

  Fly   720 QQEEMVCVPIDEVNNSFFMSHYMQAVPMEEDGSGQHII-----VFEQPGQNMDMMSIYDQQQV-- 777
            ||||    |....||    :|..::.|       :|:.     ..:||..|..|  ||.|:..
Mosquito   874 QQEE----PSHAHNN----NHLPESPP-------RHMFGELPKAKQQPPGNSRM--IYTQKSATK 921

  Fly   778 GEPMHESGVP---KRPAEENARVVVVKNNPTK 806
            ..|......|   ||||.:..|.......|.|
Mosquito   922 AAPASSRKTPSARKRPAAKEQRPAAAPPPPVK 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	74/266 (28%)
		C2H2 Zn finger	469..490	CDD:275368	9/47 (19%)
		zf-C2H2	511..533	CDD:278523	6/21 (29%)
		C2H2 Zn finger	513..564	CDD:275368	16/52 (31%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	11/25 (44%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	11/23 (48%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	7/17 (41%)
AgaP_AGAP008984	XP_319733.4	C2H2 Zn finger	120..140	CDD:275368	4/19 (21%)
		C2H2 Zn finger	148..168	CDD:275368	5/19 (26%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..366	CDD:275368	2/20 (10%)
		C2H2 Zn finger	402..420	CDD:275368	6/17 (35%)
		C2H2 Zn finger	462..482	CDD:275368	9/19 (47%)
		C2H2 Zn finger	494..511	CDD:275368	0/16 (0%)
		C2H2 Zn finger	524..544	CDD:275370	1/19 (5%)
		C2H2 Zn finger	552..572	CDD:275370	6/19 (32%)
		C2H2 Zn finger	579..599	CDD:275368	8/25 (32%)
		zf-C2H2	605..627	CDD:278523	8/21 (38%)
		C2H2 Zn finger	607..627	CDD:275368	7/19 (37%)
		zf-H2C2_2	621..643	CDD:290200	10/21 (48%)
		C2H2 Zn finger	635..655	CDD:275368	7/19 (37%)
		zf-H2C2_2	648..672	CDD:290200	15/23 (65%)
		C2H2 Zn finger	663..683	CDD:275368	9/19 (47%)
		C2H2 Zn finger	700..720	CDD:275368	0/19 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100