Protein Alignment topi and LOC1272487

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_061515235.1
• Gene: LOC1272487 / 1272487
• VectorBaseID: AGAMI1_008231
• Length: 492
• Species: Anopheles gambiae
• Alignment Length: 472
• Identity: 111/472 - (23%)
• Similarity: 185/472 - (39%)
• Gaps: 93/472 - (19%)

  Fly   230 CTMCDRK------FVHASG----LVRHMEKHALDLIPSQTSEQ---PHTIPAA---GLHVVV--- 275
            |.:|..:      :.:..|    .:|:..|.||||:..:.::.   |:.:..|   .|:|:|
Mosquito    31 CRLCLSRERLISIYCNVQGRNVYFIRNFVKFALDLLKIKINKNDALPNFLCEACEKNLNVIVNFK 95

  Fly   276 -KCNSCGRIFYDPQVAFRHGLIHDSE------HSTMRQSPMTQVPSNRADFNELLLDGEMLIDND 333
             ||:...:|.:  ::.......:.||      ..:.|:|...:|..|..:..:.|..| :.:...
Mosquito    96 RKCDDSIQILH--RIREEKAKTNRSEKTDVLPRKSKRKSATKRVKQNCEEILKKLPHG-IRVQKR 157

  Fly   334 PAFATS---NQNTNPPKKEMFSS-------LILGS---VLQCEFCEYIFADIAELLVHS---ASH 382
            .|..|.   .:||.....|..:|       ||.|.   .:|.|........:.|.|...   |::
Mosquito   158 SANLTQKDVEENTENEGSERITSSGASMCALIEGQNKPEVQNEAAVTEQDRVIEALNDDGKCATY 222

  Fly   383 VAERRFECTACDI-QMNTAKEASIHFQTDCIFMRE---AIRSLNVTLSRYFVCNVCELKFAN--- 440
            ..|..|..|..:: :::..:|.:|..|.:|.....   |:.|..........|:||.....|
Mosquito   223 EEEIEFTYTDDNLEEVDHPEEVTIIIQNECPIGTSDATALESKKPVTKEKIACSVCGTSVNNIRS 287

  Fly   441 ---TDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRN 502
               ...::.||                    ||.|..:|...|...:|....||.|
Mosquito   288 HMAIHSVRSHR--------------------CDQCPKSFTSRHKLQSHINGVHLRK--------- 323

  Fly   503 TGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGE 567
                  |.:.|:||||::.::::|..|:|.|.|.:.:.|  :.|.::|.....|..|: ..|:.|
Mosquito   324 ------RDFKCEICGKAFLENNNLKGHMRIHSGERKYAC--DLCPKRFLFAGTLRSHM-LTHSQE 379

  Fly   568 RPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCT 632
            :.:.|.:|.|.||..:...:|..:|.||:.:.|..|.|||.....|..|.|.||||||..|..|.
Mosquito   380 KHHKCEICDKLFLLRTTLNKHLRVHTGEKPHSCSVCDKRFRTTTHLAVHMRTHTGEKPLCCRICG 444

  Fly   633 KTFRQRGDRDKHIRARH 649
            ..|.....|..|::|:|
Mosquito   445 MAFAHHKGRSVHMKAKH 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	4/29 (14%)
		C2H2 Zn finger	277..297	CDD:275370	2/19 (11%)
		C2H2 Zn finger	431..453	CDD:275368	6/27 (22%)
		COG5048	<450..647	CDD:227381	55/196 (28%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		C2H2 Zn finger	513..564	CDD:275368	15/50 (30%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:463886	12/24 (50%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
LOC1272487	XP_061515235.1	None