Protein Alignment topi and LOC1272068

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_310938.6
• Gene: LOC1272068 / 1272068
• VectorBaseID: AGAMI1_013905
• Length: 713
• Species: Anopheles gambiae
• Alignment Length: 544
• Identity: 120/544 - (22%)
• Similarity: 187/544 - (34%)
• Gaps: 112/544 - (20%)

  Fly   194 RENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLI--- 255
            :.|........|:..::..|..::..|:...| |.....|:||:.....|..|::.|...|:
Mosquito   213 KSNNANSSERSKEGARFTFAALLKHYRQVHGK-PGYAVCCNRKYTRRRSLKMHLQTHGRKLVYRC 276

  Fly   256 -------PSQTSEQPHTIPAAGLHVV-----VKCNSCGRIFYDPQVAFRHGLIHDS--------- 299
                   ..|.|...|.:.   :|..     .:|:.|.:.|....:...|||.|::
Mosquito   277 VPCGIKFRKQESLDEHNLL---IHTSEEEKRYRCDKCDKAFATEHLLNSHGLWHENVARKNITCS 338

  Fly   300 ------------------EHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPP 346
                              .|.:|..|.:: |||......| .:|.|.|:.:.  :.|....|...
Mosquito   339 VCNIFFTSQPSLKKHRALHHPSMESSDVS-VPSTNGSTAE-AVDDEKLVASQ--YRTRISATEIG 399

  Fly   347 KKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACD----IQMNTAKEASIHF 407
            ::|..  :....:|.|..|.:......:|..|:|.....|..:...|:    .:.:..:...:|.
Mosquito   400 EQEKL--IRRHCLLHCSRCAFFGESFTQLKEHAAEAHGLRSCDVVCCERTYSKRQSLYEHCLVHE 462

  Fly   408 QTDCIFMREAIRSLNVTLS--------------RYFVCNVCELKFANTDLLQEHRCTSFHYFPRL 458
            ..||.......:|.:.:.|              |.|.|:||...|....||::|.........:|
Mosquito   463 NPDCFRCDVCGKSYSSSRSLQNHKWRIHTPAAERPFRCDVCGETFVKDYLLKQHLVHHLAKHKKL 527

  Fly   459 NENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQS 523
            |.        ||.|:.:|..|.....|.:..|             |.|  ...:||||.|.:...
Mosquito   528 NH--------CDVCERSFTTATVLKCHQQTYH-------------GGG--FALICDICAKGFNSR 569

  Fly   524 SHLWQHLRFH--QGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFY 586
            :....|...|  :|......|.|.|.:....:.....|..:|||.:.|..|..|||..:..|...
Mosquito   570 ALFENHRLTHSVEGKSQLKHQCEQCKKWLRNKKSYQQHRIRCHTNDGPVTCKFCGKESVNASALK 634

  Fly   587 QHRLIHRGER-RYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHS 650
            .|..:|...| .|.|..|.|||..|..|:.|:..|||...|.|.:|.:||....:..||.:|.|
Mosquito   635 SHVHLHHAARPEYPCTLCDKRFKTALRLREHEATHTGTALYRCPWCPRTFACGSNMYKHKKAGH- 698

  Fly   651 HLDANSRLMMQMQKFQLETAAAQK 674
                           .||.||:.|
Mosquito   699 ---------------PLEWAASVK 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275370	6/19 (32%)
		C2H2 Zn finger	431..453	CDD:275368	7/21 (33%)
		COG5048	<450..647	CDD:227381	54/199 (27%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		C2H2 Zn finger	513..564	CDD:275368	12/52 (23%)
		C2H2 Zn finger	541..561	CDD:275368	4/19 (21%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:463886	10/24 (42%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
LOC1272068	XP_310938.6	None