Protein Alignment topi and AgaP_AGAP012741

DIOPT Version :9

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_306506.3
• Gene: AgaP_AGAP012741 / 1267949
• VectorBaseID: AGAP012741
• Length: 390
• Species: Anopheles gambiae
• Alignment Length: 460
• Identity: 100/460 - (21%)
• Similarity: 163/460 - (35%)
• Gaps: 117/460 - (25%)

  Fly   243 LVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSC----GRIFYDPQVAFRHGLIHDSE--- 300
            |.||:   :|.::|..               |::|..|    |.:  .....||:..|.:.|
Mosquito     1 LHRHL---SLQILPDD---------------VLRCAICFECLGSL--KKSTDFRYACIRNDETFR 45

  Fly   301 ------HSTMRQSP--MTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNT------NPPKKEMF 351
                  .|..::.|  :...|....|.:.|.|..:||||........:::|      |...:|..
Mosquito    46 RLCVGPSSVGKKEPVKLGHNPMVHPDADPLELKFDMLIDEVVETKLYDEDTSIQIIANQDARETV 110

  Fly   352 SSLILGSVLQCEFCEYIFADIAELLVHSASHVAE-----------------------RRFECTAC 393
            |            ||    ::||...::|.:.|.                       ||.:....
Mosquito   111 S------------CE----EVAEAEEYNAPYSANYIELGEPFSDDTDTDEPKRKGKPRRRKADLN 159

  Fly   394 DIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRY--FVCNVCELKFANTDLLQEHRCTSFHYFP 456
            ..:.:..|:.|   :|..|...|:..||.....::  .:|.||.:...|.|             .
Mosquito   160 GTRSDATKQPS---RTPTILENESDPSLKPKAPKHKKVLCYVCGIWITNID-------------G 208

  Fly   457 RLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYT 521
            .:..:.|:....|..|.|              |.:||....:..:.....||..| |::|||.:|
Mosquito   209 HIASHNKQANFACPHCPV--------------KMINKCNLMRHVKQVHEKRIIMY-CELCGKGFT 258

  Fly   522 QSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFY 586
            ..::...|:..|...:.:.|..  |..||..:..|.:|.|..|..| .:.|..||..|.|.....
Mosquito   259 HKNNYVSHMVSHNIGRTYDCSV--CFVKFRHQGALRNHFRSVHLNE-TFPCATCGMVFRTPERLK 320

  Fly   587 QHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSH 651
            :|:.:|..|:.|.|.:|.|||....|...|:..||| ..:.|..|.|::|.:.....|.|..|..
Mosquito   321 RHQPVHSTEQPYVCRQCPKRFKYRYARTIHEITHTG-VIFRCRHCDKSYRYKAQLKVHQRKTHPD 384

  Fly   652 LDANS 656
            .:::|
Mosquito   385 SESDS 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	3/6 (50%)
		C2H2 Zn finger	277..297	CDD:275368	5/23 (22%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	50/196 (26%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	14/50 (28%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	9/25 (36%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	9/23 (39%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	8/24 (33%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
AgaP_AGAP012741	XP_306506.3	zf-AD	<1..46	CDD:214871	13/64 (20%)
		C2H2 Zn finger	196..213	CDD:275368	5/29 (17%)
		C2H2 Zn finger	221..242	CDD:275368	6/34 (18%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	361..382	CDD:275368	6/20 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910