DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Prdm1

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_006512568.1	Gene:	Prdm1 / 12142	MGIID:	99655	Length:	856	Species:	Mus musculus

Alignment Length:	180	Identity:	61/180 - (33%)
Similarity:	95/180 - (52%)	Gaps:	25/180 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 GRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPY 570
            |:|: |.|::|.|::.|.|:|..|||.|.|.:||.||  .|::.||....|..|. ..||||:|:
Mouse   602 GKIK-YECNVCAKTFGQLSNLKVHLRVHSGERPFKCQ--TCNKGFTQLAHLQKHY-LVHTGEKPH 662

  Fly   571 LCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTF 635
            .|.||.|||.:.|....|..:|.||:.|:|:.|..:|.:...||.|:|:||.|:|:.|..|.|::
Mouse   663 ECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCAQCHKSY 727

  Fly   636 RQRGDRDKHIRARHSHLDAN--------------SRLMMQMQKFQLETAA 671
                   .|:.:...||..|              :|:..::::|.:...|
Mouse   728 -------IHLCSLKVHLKGNCPAGPAAGLPLEDLTRINEEIERFDISDNA 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368
		COG5048	<450..647	CDD:227381	55/140 (39%)
		C2H2 Zn finger	469..490	CDD:275368
		zf-C2H2	511..533	CDD:278523	10/21 (48%)
		C2H2 Zn finger	513..564	CDD:275368	20/50 (40%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..609	CDD:290200	8/23 (35%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	11/24 (46%)
		C2H2 Zn finger	628..646	CDD:275368	4/17 (24%)
Prdm1	XP_006512568.1	PR-SET_PRDM1	112..240	CDD:380964
		COG5048	452..719	CDD:227381	51/120 (43%)
		C2H2 Zn finger	608..628	CDD:275368	9/19 (47%)
		C2H2 Zn finger	636..656	CDD:275368	7/22 (32%)
		C2H2 Zn finger	664..684	CDD:275368	8/19 (42%)
		C2H2 Zn finger	692..712	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..738	CDD:275368	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910