DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and LOC116411645

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_031760205.1	Gene:	LOC116411645 / 116411645	-ID:	-	Length:	918	Species:	Xenopus tropicalis

Alignment Length:	497	Identity:	130/497 - (26%)
Similarity:	188/497 - (37%)	Gaps:	119/497 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 RRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHT 265
            :.|:...||  :.||         :.|..||.|.:.||..:|||.||..|        |.|:|.|
Frog   364 KNYLVSHMK--IHTG---------EKPFTCTECGKGFVQKNGLVSHMRIH--------TGEKPFT 409

  Fly   266 IPAAGLHVVVK-----------------CNSCGRIFYDPQVAFRHGLI-HDSEHSTMRQSPMTQV 312
            ....|...|.|                 |..||:.|     |.::||: |...|:..:....|:.
Frog   410 CTECGKGFVQKNGLVSHMKIHTGEKPFTCTECGKGF-----AQKNGLVSHMKIHTREKPFTCTEC 469

  Fly   313 PSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLV 377
            ....|..|.|:               |:...:..:|.          ..|..|...||...:|:.
Frog   470 GKGFAHKNNLV---------------SHMRIHTGEKP----------FTCTECGKGFAQKIDLVS 509

  Fly   378 HSASHVAERRFECTACD----IQMNTAKEASIHFQ------TDC----IFMREAIRSLNV-TLSR 427
            |...|..|:.|.||.|.    .:.|......||..      |:|    ......:..:.| |..:
Frog   510 HMKIHTGEKPFTCTECGKGFAHRHNLVSHMKIHTGEKPFTCTECGKGFAHKYSLVPHMKVHTGEK 574

  Fly   428 YFVCNVCELKFANTDLLQEH----------RCT--------SFHYFPRLNENGKKLLLPCDFCDV 474
            .|.|..|...||....|..|          .||        .:...|.:..:..:....|..|..
Frog   575 PFTCTECGKGFAQKINLVSHMKIHTGEKPFTCTECGKGFAHKYSLVPHMKVHTGEKPFTCTECGK 639

  Fly   475 NFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPF 539
            .|...::.::|.:             .:||.   :.:.|..|||.:.|.::|..|::.|.|.|||
Frog   640 GFAHKNNLVSHMK-------------IHTGE---KPFTCTECGKGFAQKNNLVSHMKIHTGEKPF 688

  Fly   540 VCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECG 604
            .|.|  |.:.|..:.||..|: |.||||:|:.|..|||.|........|..||.||:.:.|.|||
Frog   689 TCTE--CGKGFAQKIDLVSHM-KIHTGEKPFTCTECGKGFAHRHSLVSHMRIHTGEKPFTCTECG 750

  Fly   605 KRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIR 646
            |.|.:...|.:|.:|||||||::|..|.|.|.|:.....|::
Frog   751 KGFAQKINLVSHMKIHTGEKPFTCTECGKGFAQKNTLVSHMK 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	10/19 (53%)
		C2H2 Zn finger	277..297	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..453	CDD:275368	8/39 (21%)
		COG5048	<450..647	CDD:227381	64/205 (31%)
		C2H2 Zn finger	469..490	CDD:275368	4/20 (20%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	20/50 (40%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	14/25 (56%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	11/23 (48%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	13/24 (54%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
LOC116411645	XP_031760205.1	C2H2 Zn finger	74..94	CDD:275368
		COG5048	102..482	CDD:227381	37/156 (24%)
		C2H2 Zn finger	102..122	CDD:275368
		C2H2 Zn finger	130..150	CDD:275368
		C2H2 Zn finger	158..178	CDD:275368
		C2H2 Zn finger	186..206	CDD:275368
		C2H2 Zn finger	214..234	CDD:275368
		C2H2 Zn finger	242..262	CDD:275368
		C2H2 Zn finger	270..290	CDD:275368
		C2H2 Zn finger	298..318	CDD:275368
		C2H2 Zn finger	326..346	CDD:275368
		C2H2 Zn finger	354..374	CDD:275368	3/11 (27%)
		C2H2 Zn finger	382..402	CDD:275368	10/19 (53%)
		C2H2 Zn finger	410..430	CDD:275368	3/19 (16%)
		COG5048	434..830	CDD:227381	106/408 (26%)
		C2H2 Zn finger	438..458	CDD:275368	8/24 (33%)
		C2H2 Zn finger	466..486	CDD:275368	5/34 (15%)
		C2H2 Zn finger	494..514	CDD:275368	6/19 (32%)
		C2H2 Zn finger	522..542	CDD:275368	4/19 (21%)
		C2H2 Zn finger	550..570	CDD:275368	2/19 (11%)
		C2H2 Zn finger	578..598	CDD:275368	6/19 (32%)
		C2H2 Zn finger	606..626	CDD:275368	3/19 (16%)
		C2H2 Zn finger	634..654	CDD:275368	4/32 (13%)
		C2H2 Zn finger	662..682	CDD:275368	7/19 (37%)
		C2H2 Zn finger	690..710	CDD:275368	8/22 (36%)
		C2H2 Zn finger	718..738	CDD:275368	6/19 (32%)
		C2H2 Zn finger	746..766	CDD:275368	8/19 (42%)
		C2H2 Zn finger	774..794	CDD:275368	6/19 (32%)
		C2H2 Zn finger	802..822	CDD:275368
		C2H2 Zn finger	830..850	CDD:275368
		zf-H2C2_2	842..867	CDD:404364
		C2H2 Zn finger	858..878	CDD:275368
		zf-H2C2_2	870..895	CDD:404364
		C2H2 Zn finger	886..906	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910