DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment topi and OSR2

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:NP_001273770.1 Gene:OSR2 / 116039 HGNCID:15830 Length:433 Species:Homo sapiens


Alignment Length:213 Identity:59/213 - (27%)
Similarity:96/213 - (45%) Gaps:35/213 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   453 HYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEE----------------KHLNKKKREKETR 501
            |..|.|:::..:           |:||:..:|.::|                ..::...:....|
Human   225 HVLPALHKDRPR-----------FDFANLAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLTPDR 278

  Fly   502 NTGAGRI-----RQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIR 561
            ....||:     ::::|..||:.:|:|.:|..|.|.|...:|:.|  :.|.:.|..:..|.|| |
Human   279 KPSRGRLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTC--DICHKAFRRQDHLRDH-R 340

  Fly   562 KCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPY 626
            ..|:.|:|:.|..|||.|........|:.:|..|..::|..||:.|.:...||.|...||..|||
Human   341 YIHSKEKPFKCQECGKGFCQSRTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPY 405

  Fly   627 SCLFCTKTFRQRGDRDKH 644
            ||..|.|.||:..|..:|
Human   406 SCEQCGKVFRRNCDLRRH 423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368 59/213 (28%)
COG5048 <450..647 CDD:227381 59/213 (28%)
C2H2 Zn finger 469..490 CDD:275368 5/36 (14%)
zf-C2H2 511..533 CDD:278523 8/21 (38%)
C2H2 Zn finger 513..564 CDD:275368 17/50 (34%)
C2H2 Zn finger 541..561 CDD:275368 6/19 (32%)
zf-H2C2_2 555..581 CDD:290200 12/25 (48%)
C2H2 Zn finger 572..592 CDD:275368 6/19 (32%)
zf-H2C2_2 585..609 CDD:290200 7/23 (30%)
zf-C2H2 598..620 CDD:278523 7/21 (33%)
C2H2 Zn finger 600..620 CDD:275368 7/19 (37%)
zf-H2C2_2 612..637 CDD:290200 13/24 (54%)
C2H2 Zn finger 628..646 CDD:275368 7/17 (41%)
OSR2NP_001273770.1 COG5048 <293..428 CDD:227381 48/134 (36%)
C2H2 Zn finger 295..315 CDD:275368 8/19 (42%)
zf-H2C2_2 307..332 CDD:290200 8/26 (31%)
C2H2 Zn finger 323..343 CDD:275368 7/22 (32%)
zf-H2C2_2 335..358 CDD:290200 11/23 (48%)
C2H2 Zn finger 351..371 CDD:275368 6/19 (32%)
zf-C2H2 377..399 CDD:278523 7/21 (33%)
C2H2 Zn finger 379..399 CDD:275368 7/19 (37%)
zf-H2C2_2 391..416 CDD:290200 13/24 (54%)
C2H2 Zn finger 407..427 CDD:275368 7/17 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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