DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and AgaP_AGAP012950

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_003435799.1	Gene:	AgaP_AGAP012950 / 11175862	VectorBaseID:	AGAP012950	Length:	712	Species:	Anopheles gambiae

Alignment Length:	152	Identity:	42/152 - (27%)
Similarity:	65/152 - (42%)	Gaps:	21/152 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 GERR----YECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHL-- 652
            |:|:    :.|..|.|.|....::..|.|.||||||::|..|.|:|||:....||.:   :||
Mosquito   561 GQRKERSLHYCSICSKGFKDKYSVNVHIRTHTGEKPFACSLCGKSFRQKAHLAKHYQ---THLAQ 622

  Fly   653 --DANSRLMMQMQKFQLET--AAAQKAQSHNPEQQDNDVAGGASTSDVPSGSGFMSTEPSVAEMQ 713
              .....:..|.::.:|.|  ||:..|.|.....|...||     |..|.....:|....:..|
Mosquito   623 KNPPGGTVTKQSKQSRLSTPLAASSSAGSDPSTGQSMPVA-----SVTPVTLSVVSVAGPLPPM- 681

  Fly   714 YSITPEQQEEMVCVPIDEVNNS 735
              :.|:.|...:.:.....||:
Mosquito   682 --VIPQAQSPPMLLTTTTTNNN 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368
		COG5048	<450..647	CDD:227381	22/56 (39%)
		C2H2 Zn finger	469..490	CDD:275368
		zf-C2H2	511..533	CDD:278523
		C2H2 Zn finger	513..564	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368
		zf-H2C2_2	555..581	CDD:290200
		C2H2 Zn finger	572..592	CDD:275368
		zf-H2C2_2	585..609	CDD:290200	6/18 (33%)
		zf-C2H2	598..620	CDD:278523	6/21 (29%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:290200	12/24 (50%)
		C2H2 Zn finger	628..646	CDD:275368	8/17 (47%)
AgaP_AGAP012950	XP_003435799.1	COG5048	568..>660	CDD:227381	30/94 (32%)
		zf-C2H2	569..591	CDD:278523	6/21 (29%)
		C2H2 Zn finger	571..591	CDD:275370	6/19 (32%)
		zf-H2C2_2	583..608	CDD:290200	12/24 (50%)
		C2H2 Zn finger	599..619	CDD:275370	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100