DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and LOC110437722

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_021330543.1	Gene:	LOC110437722 / 110437722	-ID:	-	Length:	801	Species:	Danio rerio

Alignment Length:	635	Identity:	163/635 - (25%)
Similarity:	236/635 - (37%)	Gaps:	164/635 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 KMTTEQSVF---HGSRSNSSASTVNR---------IKCPTCLVQFDAVAFQNHSCEAKPIEVAVP 166
            |:.||:..|   ...:|....||:|.         .:|..|...|   .|.::..:    .:.:.
Zfish    76 KIHTEEKPFTCTECGKSFRQISTLNTHTILTGEKPFRCTLCGKSF---TFSSNYTK----HLRIH 133

  Fly   167 QQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEM--------KYDLATGIESSRK-N 222
            ..|||.   |.|......|...|..:||..::    :.:|::        .:...:.:::.:| :
Zfish   134 TGEKPF---TCSQCGKRFSVSQSSILIRHMKI----HTEDKLFTCTQCGKSFRQISSLDTHKKIH 191

  Fly   223 AAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAG--------------LHV 273
            ..:.|..||:|.:.|..:|....||..|        |..:|.|....|              :|.
Zfish   192 TGEKPLTCTLCGKSFTFSSNYNDHMMIH--------TGVKPFTCTQCGKSFTFSSNYNQHMRIHS 248

  Fly   274 VVK---CNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPA 335
            ..|   |:.||:.|.......:|..||..|      .|.|.....::......|.|.|.|
Zfish   249 GEKPFTCSQCGKSFSISSYLIKHMRIHTGE------KPYTCSQCGQSFRQTSTLKGHMEI----- 302

  Fly   336 FATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTA 400
                :....|              ..|..|...|..||.|..|...|..|:.|.||.|......:
Zfish   303 ----HTGEKP--------------FTCTECGKSFRKIATLKGHMRIHTGEKPFRCTQCGKSFTLS 349

  Fly   401 KEASIHFQ----------TDCIFMREAIRSLNV-----TLSRYFVCNVCELKFANTDLLQEH--- 447
            ...:.|.:          :.|......:.|||.     |..:.:.|..|...|..|.:|..|
Zfish   350 SNYNQHMRIHTGEKPFTCSQCGKSFSMLSSLNQHMRIHTGEKPYTCTQCGQSFRQTSVLNRHMKI 414

  Fly   448 -------RCT----SFHYFPRLNEN-----GKKLLLPCDFCDVNF----EFAHDFLAHSEEK--- 489
                   .||    ||.|...|||:     |:| ...|..|..:|    ..:...:.|..||
Zfish   415 HTGEKPFTCTQCGKSFSYSSSLNEHMVIHTGEK-PFTCTQCGKSFSRSSNLSQHMMIHVGEKPFI 478

  Fly   490 ------------HLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQ 542
                        :||    :..|.:||.   :.:.|..||||::|||:|.|||..|.|.||:.|.
Zfish   479 CTQCGKSFCRLSNLN----QHMTTHTGE---KPFTCSQCGKSFSQSSNLNQHLTIHTGEKPYTCT 536

  Fly   543 EENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRF 607
            :  |.:.|:....||.|: ..||||:|:.|..|||.|...:....|.:||.||..:.|.:|||.|
Zfish   537 Q--CGKSFSQSSSLNKHM-MIHTGEKPFTCSQCGKSFNQSTNLNHHMMIHTGETPFTCTQCGKSF 598

  Fly   608 YRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSR 657
            .::.:||.||.||||||||.|..|.|.|.|.           |||.|:.|
Zfish   599 SQSSSLKQHQMIHTGEKPYKCSHCDKRFSQT-----------SHLKAHER 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	9/35 (26%)
		COG5048	<450..647	CDD:227381	79/224 (35%)
		C2H2 Zn finger	469..490	CDD:275368	6/39 (15%)
		zf-C2H2	511..533	CDD:278523	12/21 (57%)
		C2H2 Zn finger	513..564	CDD:275368	22/50 (44%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	10/23 (43%)
		zf-C2H2	598..620	CDD:278523	9/21 (43%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	16/24 (67%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
LOC110437722	XP_021330543.1	COG5048	52..486	CDD:227381	94/461 (20%)
		C2H2 Zn finger	58..78	CDD:275368	1/1 (100%)
		C2H2 Zn finger	86..105	CDD:275368	4/18 (22%)
		C2H2 Zn finger	113..133	CDD:275368	4/26 (15%)
		C2H2 Zn finger	141..163	CDD:275368	5/25 (20%)
		C2H2 Zn finger	171..191	CDD:275368	1/19 (5%)
		C2H2 Zn finger	199..219	CDD:275368	7/19 (37%)
		C2H2 Zn finger	227..247	CDD:275368	1/19 (5%)
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..303	CDD:275368	4/28 (14%)
		C2H2 Zn finger	311..331	CDD:275368	7/19 (37%)
		COG5048	335..747	CDD:227381	101/325 (31%)
		C2H2 Zn finger	339..359	CDD:275368	4/19 (21%)
		C2H2 Zn finger	367..387	CDD:275368	4/19 (21%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	3/19 (16%)
		C2H2 Zn finger	479..499	CDD:275368	3/23 (13%)
		C2H2 Zn finger	507..527	CDD:275368	12/19 (63%)
		C2H2 Zn finger	535..555	CDD:275368	6/22 (27%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		C2H2 Zn finger	591..611	CDD:275368	9/19 (47%)
		C2H2 Zn finger	619..639	CDD:275368	10/30 (33%)
		C2H2 Zn finger	647..667	CDD:275368
		C2H2 Zn finger	675..695	CDD:275368
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	731..751	CDD:275368
		C2H2 Zn finger	759..779	CDD:275368
		C2H2 Zn finger	784..800	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910