DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and ZNF765-ZNF761

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001337425.1	Gene:	ZNF765-ZNF761 / 110116772	-ID:	-	Length:	746	Species:	Homo sapiens

Alignment Length:	713	Identity:	173/713 - (24%)
Similarity:	262/713 - (36%)	Gaps:	202/713 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 VERTLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTS--------SKMTTEQ--SVFHGS- 125
            |::.:.|..|:....|.:|.     :|...||:. |.|:|.        :|...:|  |.||..
Human    90 VDKDIHDYEFQWQEDERNGH-----EAPMTKIKK-LTGITERYDQSHARNKPIKDQLGSSFHSHL 148

  Fly   126 --------------------RSNSSASTVNRIKC--PTCLVQFDAVAFQNHSCEAKPIEVAVPQQ 168
                                ...|..||..||.|  .|.:.......|.|.|        .:.|:
Human   149 PEMHIFQTEEKIDNQVVKSVHDASLVSTAQRISCRPKTHISNNHGNNFWNSS--------LLTQK 205

  Fly   169 EKPHLVPTVSAPPAPLSKPASE--------RVIRENQVRLRRYIKDEMKYDLATGIESSRKNAA- 224
            ::.|:        ...|...:|        .::|::|:   .::.|:.|.|:...:.:.::|.|
Human   206 QEVHM--------REKSFQCNESGKAFNYSSLLRKHQI---IHLADKYKCDVCGKLFNQKRNLAC 259

  Fly   225 -------KGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGR 282
                   :.|.:|..|.:.|...|.|..|...|        |.|:|:           ||..|.:
Human   260 HRRCHTGENPYKCNECGKTFSQTSSLTCHRRLH--------TGEKPY-----------KCEECDK 305

  Fly   283 IFYDPQVAFRHGLIHDSEH--------STMRQ-SPMTQVPSNRADFNELLLDGEMLIDNDPAFAT 338
            .|:...:..||.:||..|.        .|.|| |.:|:        :..|..||.....:....|
Human   306 AFHFKSILERHRIIHTEEKPYKCNECGKTFRQKSILTR--------HHRLHTGEKPYKCNECGKT 362

  Fly   339 SNQNTNPPKKEMFSSLILGSVL-------QCEFCEYIFADIAELLVHSASHVAERRFECTACD-- 394
            .:..         |||.....|       :|..|...|:..:.|..|...|..|:.::|..||
Human   363 FSHK---------SSLTCHHRLHTGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPYKCEECDKA 418

  Fly   395 --IQMNTAKEASIHFQTDCIFMREAIRSLNVTLS-----------RYFVCNVCELKFANTDLLQE 446
              .:.|......||.:.:.....|..::.:.|.|           :.:.|..|:..|.....|:.
Human   419 YSFRSNFEIHRKIHTEDNAYKCNECGKTFSRTSSLTCHRRRHTGEQPYKCEECDKAFRFKSNLER 483

  Fly   447 HRCTSFHYFP-RLNENGK-----------------KLLLPCDFCDVNFEFAHDFLA----HSEE- 488
            ||.......| :.||.||                 :....|:.|...|.:......    ||.|
Human   484 HRRIHTGEKPYKCNECGKTFSRKSYLTCHHRLHTGEKAYKCNECGKTFSWKSSLTCHRRLHSGEK 548

  Fly   489 --------KHLNKKKREKETRNTGAG-------------------RIRQ--------YLCDICGK 518
                    |..|::...|..|...:|                   .|.|        |.|:.|||
Human   549 PYKCKECGKTFNQQLTLKRHRRLHSGENPYKCEDSDKAYSFKSNLEIHQKIHTEENPYKCNECGK 613

  Fly   519 SYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGS 583
            :::::|.|..|.|.|.|.||:.|:|  ||:.|.::.:|..| |:.||||:||.|..|||.|...|
Human   614 TFSRTSSLTCHRRLHTGEKPYKCEE--CDKAFRVKSNLEGH-RRIHTGEKPYKCNECGKTFSRKS 675

  Fly   584 VFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIR 646
            .|..|..:|.||:.|:|.||||.|.:..:|..|.|:|||||||.|..|.|||.|:.:...|.|
Human   676 YFICHHRLHTGEKPYKCNECGKNFSQKSSLICHHRLHTGEKPYKCNECGKTFSQKSNLTCHRR 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	81/255 (32%)
		C2H2 Zn finger	469..490	CDD:275368	6/33 (18%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	20/50 (40%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	14/25 (56%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..609	CDD:290200	12/23 (52%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	7/17 (41%)
ZNF765-ZNF761	NP_001337425.1	KRAB	7..48	CDD:307490
		C2H2 Zn finger	217..237	CDD:275368	3/22 (14%)
		COG5048	242..617	CDD:227381	82/410 (20%)
		C2H2 Zn finger	244..264	CDD:275368	3/19 (16%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		C2H2 Zn finger	328..348	CDD:275368	5/27 (19%)
		C2H2 Zn finger	356..376	CDD:275368	4/28 (14%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		C2H2 Zn finger	412..432	CDD:275368	4/19 (21%)
		C2H2 Zn finger	440..460	CDD:275368	3/19 (16%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		C2H2 Zn finger	496..516	CDD:275368	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	3/19 (16%)
		C2H2 Zn finger	552..572	CDD:275368	4/19 (21%)
		C2H2 Zn finger	580..600	CDD:275368	2/19 (11%)
		C2H2 Zn finger	608..628	CDD:275368	8/19 (42%)
		C2H2 Zn finger	636..656	CDD:275368	8/22 (36%)
		SFP1	<651..737	CDD:227516	42/86 (49%)
		C2H2 Zn finger	664..684	CDD:275368	8/19 (42%)
		C2H2 Zn finger	692..712	CDD:275368	9/19 (47%)
		C2H2 Zn finger	720..740	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910