DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and LOC101883139

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_005163465.1	Gene:	LOC101883139 / 101883139	-ID:	-	Length:	600	Species:	Danio rerio

Alignment Length:	652	Identity:	137/652 - (21%)
Similarity:	226/652 - (34%)	Gaps:	230/652 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 DRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHD 298
            |.|::.:.....|.|    .|.....||.|.:|....|.:|  |::...|     :::..|:..|
Zfish    33 DEKYLSSLNQTIHRE----GLKMCSLSESPASIATDDLDLV--CSTERAI-----LSYISGIKTD 86

  Fly   299 S----EHSTMRQSP----MTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLI 355
            |    .|:....||    ::..||:.:.|:             |:|::.:           ||..
Zfish    87 SSCNFSHTGDTLSPSLFSLSPSPSSFSAFS-------------PSFSSPS-----------SSHS 127

  Fly   356 LGSVLQCEFCEYIFADIAELLVHSAS--------HVAERRFECTACDIQM-----NTAKEASIHF 407
            .||             ::||.:.|.|        ...|..:.|||...:.     :..:|.:..|
Zfish   128 SGS-------------MSELCLTSPSLSALCGPPETQELLYSCTAQPPEQHLYPKSPKQEPTAEF 179

  Fly   408 QTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCT------SFHYFPRLNENGKKLL 466
                                    ::|..|..:.:.|.::|.:      :||:|....:....|.
Zfish   180 ------------------------HLCSKKLLDKEELFQYRSSDCKEHLNFHHFQTKEQFKNSLA 220

  Fly   467 L--------------PCDF--CDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDI 515
            |              ||.:  |...:....:.:.|.|:.|::::|.|:.| ...||.:|::
Zfish   221 LSGVEGMNGHLSEQQPCKWMDCRATYGQREELVRHIEKIHIDQRKGEEFT-CFWAGCVRRH---- 280

  Fly   516 CGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFL 580
              |.:.....|..|:|.|.|.||..|..|.|::.|:...:|..|:|. ||||:||:|
Zfish   281 --KPFNARYKLLIHMRVHSGEKPNKCMFEGCNKAFSRLENLKIHLRS-HTGEKPYIC-------- 334

  Fly   581 TGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLF--CTKTFRQRGDRDK 643
                  ||            ..|.|.|..:.....|||.|...|||:|..  |||.:.......|
Zfish   335 ------QH------------PGCLKAFSNSSDRAKHQRTHLDTKPYACQLPGCTKRYTDPSSLRK 381

  Fly   644 HIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQQD----NDVAGGA------------- 691
            |::. ||     |:.:....|.||          |:|.:||    ..:.|.:
Zfish   382 HVKV-HS-----SKALQAQDKVQL----------HSPVEQDVVDLQHLQGSSPSVCSPEHRCPIS 430

  Fly   692 -----------------STSDVPSGSGFMSTEP-------SVAEMQYSITPEQQEEMVC------ 726
                             |.|...|||..:|.|.       |:....::.|...|..:||
Zfish   431 LTEIHQDGFSVYSEEDESCSRALSGSSSVSLEQLSRHSSISLHNRLHNNTINSQPRLVCGINLAS 495

  Fly   727 -----VPIDEVNNSFFMSH----YMQAVPMEED---GSGQHIIVFEQPGQNMDMMSIYDQQQVGE 779
                 ..:.|:::||..||    ....||:..:   .:..|:......|:: ||.|.   :|.|.
Zfish   496 GTNEVQSVSEIHSSFLNSHQNLNQFNEVPINHNVFQATFNHVEQISNDGRD-DMQSF---EQNGF 556

  Fly   780 PM 781
            |:
Zfish   557 PL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	4/15 (27%)
		C2H2 Zn finger	277..297	CDD:275368	3/19 (16%)
		C2H2 Zn finger	431..453	CDD:275368	4/27 (15%)
		COG5048	<450..647	CDD:227381	57/220 (26%)
		C2H2 Zn finger	469..490	CDD:275368	4/22 (18%)
		zf-C2H2	511..533	CDD:278523	4/21 (19%)
		C2H2 Zn finger	513..564	CDD:275368	15/50 (30%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	10/25 (40%)
		C2H2 Zn finger	572..592	CDD:275368	3/19 (16%)
		zf-H2C2_2	585..609	CDD:290200	5/23 (22%)
		zf-C2H2	598..620	CDD:278523	6/21 (29%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:290200	11/26 (42%)
		C2H2 Zn finger	628..646	CDD:275368	6/19 (32%)
LOC101883139	XP_005163465.1	C2H2 Zn finger	241..260	CDD:275368	3/18 (17%)
		SFP1	<293..387	CDD:227516	37/121 (31%)
		C2H2 Zn finger	307..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..356	CDD:275368	9/47 (19%)
		C2H2 Zn finger	364..386	CDD:275368	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910