DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and LOC101734875

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_031760127.1	Gene:	LOC101734875 / 101734875	-ID:	-	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	136/523 - (26%)
Similarity:	202/523 - (38%)	Gaps:	118/523 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 EAKPIEVAVPQQE---KPHLVPTVSAPPA--PLSKPASERVIRENQVRLRRYIKDEMKYDLATGI 216
            |::.:::.:.::|   :.|..|..|:..|  .::.|..|..|.:.:::......|:....:..|.
Frog    13 ESEILQIKIKEEEPDPEDHQTPMESSAVALTGVAFPEGEPEILQVKIKEEDSNSDDHLNPMDVGF 77

  Fly   217 ESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCG 281
              .:.|..:.|..||.|.:.|........|...|        |.|:|..           |:.|.
Frog    78 --PQLNTEEKPFICTECGKSFDGHRSFTTHKRIH--------TGEKPFA-----------CHLCW 121

  Fly   282 RIF-YDPQVAFRHGLIHDSEHSTMRQSPMTQVP-SNRADFNELLLDGEMLIDNDPAFATSNQNTN 344
            :.| |..|:     |.|.|.|:.::  |.|... ..|...|:.|              |::|..:
Frog   122 KKFTYKYQL-----LTHISNHAGVK--PFTCAECGKRFSLNKRL--------------TNHQKIH 165

  Fly   345 PPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACD----IQMNTAKEASI 405
            ..:|.: .||..|.::..:.         .|..|...|..|:.|.|..|.    ::....|...|
Frog   166 TGEKPL-RSLECGELVSSKH---------RLKEHQRLHAGEKPFTCPECGKSFALKYRVNKHLRI 220

  Fly   406 HFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHR------------------CTSF 452
            |                 |..:.|.|......|...|.||:.:                  |...
Frog   221 H-----------------TGEKPFACTGGGKGFCVKDELQKQQRFHSGVKPFTCAECGKGFCLRT 268

  Fly   453 HYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICG 517
            .....|..:..:..|.|..|...|....:|     :.||...:          |.: .:||..||
Frog   269 GLIKHLATHAGEKPLTCPECGQRFRLRSEF-----QNHLRLHR----------GAV-PFLCTECG 317

  Fly   518 KSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTG 582
            ||:.|.|.|..|||.|.|.|||:|.|  |.|.|.::..|..| :|.||||:|:.|..|||||...
Frog   318 KSFCQKSSLDAHLRIHTGEKPFMCTE--CGRSFNLKNGLRKH-QKIHTGEKPFKCTECGKRFSMK 379

  Fly   583 SVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRA 647
            :...:|...|.||:.:.|.||||.|....:|.||||||||:||::|..|.:.|..||...||.|.
Frog   380 TDLQKHHRTHTGEKPFICTECGKSFSHHSSLYNHQRIHTGKKPFTCTECGRGFGSRGRFYKHQRV 444

  Fly   648 RHS 650
             ||
Frog   445 -HS 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/20 (30%)
		C2H2 Zn finger	431..453	CDD:275368	6/39 (15%)
		COG5048	<450..647	CDD:227381	73/196 (37%)
		C2H2 Zn finger	469..490	CDD:275368	4/20 (20%)
		zf-C2H2	511..533	CDD:278523	12/21 (57%)
		C2H2 Zn finger	513..564	CDD:275368	24/50 (48%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	14/25 (56%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	10/23 (43%)
		zf-C2H2	598..620	CDD:278523	11/21 (52%)
		C2H2 Zn finger	600..620	CDD:275368	11/19 (58%)
		zf-H2C2_2	612..637	CDD:290200	14/24 (58%)
		C2H2 Zn finger	628..646	CDD:275368	7/17 (41%)
LOC101734875	XP_031760127.1	C2H2 Zn finger	89..109	CDD:275368	5/19 (26%)
		COG5048	113..501	CDD:227381	115/413 (28%)
		C2H2 Zn finger	117..137	CDD:275368	8/24 (33%)
		C2H2 Zn finger	145..165	CDD:275368	5/33 (15%)
		C2H2 Zn finger	173..193	CDD:275368	5/28 (18%)
		C2H2 Zn finger	201..221	CDD:275368	3/19 (16%)
		C2H2 Zn finger	229..249	CDD:275368	5/19 (26%)
		C2H2 Zn finger	257..277	CDD:275368	2/19 (11%)
		C2H2 Zn finger	285..305	CDD:275368	6/24 (25%)
		C2H2 Zn finger	313..333	CDD:275368	11/19 (58%)
		C2H2 Zn finger	341..361	CDD:275368	8/22 (36%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	11/19 (58%)
		C2H2 Zn finger	425..445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	453..473	CDD:275368
		C2H2 Zn finger	481..501	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910