DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and LOC101731242

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_017952890.2	Gene:	LOC101731242 / 101731242	-ID:	-	Length:	696	Species:	Xenopus tropicalis

Alignment Length:	748	Identity:	167/748 - (22%)
Similarity:	252/748 - (33%)	Gaps:	256/748 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VSGEYTLAEIEVELDQQLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPMPTD 69
            :.|||.        |::..|.||  |.|:...||.:                .:|..||     |
Frog   105 LDGEYE--------DKREIPADL--GGTLCYNNEPS----------------KIGAEGA-----D 138

  Fly    70 VVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTV 134
            ...:|.|.:|...              .|||..:.:   |:.....:.|:    |::|:.|
Frog   139 FCADRNLTNPEIS--------------PAEQPPLAN---GIKEEAASWEE----GNQSDCS---- 178

  Fly   135 NRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVR 199
                                         .:|..|:.....|    |.|:   .:....:.:.|.
Frog   179 -----------------------------IIPLTEQRQGTDT----PTPI---MAHTFNKSSDVN 207

  Fly   200 LRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPH 264
            ..|:  |:..:..|.......|:..:|...|..|.:.|..:...:||:..|        |..:|.
Frog   208 HNRF--DKNIHTNALHAAHLAKHPTQGTYNCPTCHKPFTKSYDFIRHLRTH--------TGVKPF 262

  Fly   265 TIPAAGLHVVVKCNSCGRIF---YDPQVAFR-HG-------------------LIHD-------S 299
            :           |:.||:.|   ::..|..| |.                   .:||       |
Frog   263 S-----------CSECGKSFTRRFNLNVHRRTHSGNIPQGQQQTAADSVKGATALHDGGNQSGCS 316

  Fly   300 EHSTMRQSPMTQVPS-------------------------------NRAD--FNELLLDGEMLID 331
            .:|.|:|:..|..|:                               |::|  .|.|.   |.:..
Frog   317 LNSFMKQTWGTDTPTPVMGSSLGNSSADNSISSGMRGSAPALWKEGNQSDCSINPLT---EQIQG 378

  Fly   332 ND---PAFATS---------------NQNTN----PPKKEMFSSLILGSVLQCEFCEYIFADIAE 374
            .|   |....|               |.|:|    .|.|.:.|:        .:.|.:.|.:..:
Frog   379 TDTPTPIMGCSLSNSSAETKTYECDKNINSNGSHESPVKNLKST--------SDECHFAFTNRRD 435

  Fly   375 LLVHSASHVAERRFECTACDIQMNTAKEASIH----------FQTDC--IFMREAIRSLNV---T 424
            |:.|..:|..|:.|.|..|........:.::|          ..:||  .|...|..:.:|   |
Frog   436 LVRHERTHTGEKPFPCPVCGKCFARCSDLNVHKGVHSGEKPFCCSDCGKCFTHRANLAAHVKTHT 500

  Fly   425 LSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEK 489
            ..:.|.|:.|...|.....|:.|         ::...|:| ...|..|..:|....:|.||.
Frog   501 DLKPFSCDKCGKCFKRRSHLKGH---------QIVHTGEK-PFSCSECGKSFAKRSNFTAHC--- 552

  Fly   490 HLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRP 554
                     .|...|    :.:.|..|||.:...:....|.|.|.|..||.|.|  |.:.||.|.
Frog   553 ---------STHTDG----KTFTCSDCGKGFKYRADFKVHQRLHLGENPFPCSE--CGKSFTRRS 602

  Fly   555 DLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRI 619
            .|..|: |.||||:|:.|..|||.|...|....||.:|.|||.:.|.||||.|.:...|..|:|.
Frog   603 HLIVHL-KTHTGEKPFTCPECGKSFTQRSDMNIHRRLHTGERPFPCPECGKCFSQFSYLNVHRRT 666

  Fly   620 HTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHL 652
            ||||:|:||..|.|.|:||...:.|   |..||
Frog   667 HTGERPFSCDECGKCFKQRTHLNVH---RKIHL 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/42 (17%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	68/196 (35%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		zf-C2H2	511..533	CDD:278523	6/21 (29%)
		C2H2 Zn finger	513..564	CDD:275368	19/50 (38%)
		C2H2 Zn finger	541..561	CDD:275368	8/19 (42%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..609	CDD:290200	12/23 (52%)
		zf-C2H2	598..620	CDD:278523	9/21 (43%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	13/24 (54%)
		C2H2 Zn finger	628..646	CDD:275368	7/17 (41%)
LOC101731242	XP_017952890.2	KRAB_A-box	64..>93	CDD:413388
		COG5048	233..636	CDD:227381	99/461 (21%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..443	CDD:275368	4/18 (22%)
		C2H2 Zn finger	451..471	CDD:275368	3/19 (16%)
		C2H2 Zn finger	479..499	CDD:275368	5/19 (26%)
		C2H2 Zn finger	507..527	CDD:275368	5/28 (18%)
		C2H2 Zn finger	535..555	CDD:275368	6/31 (19%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		C2H2 Zn finger	591..611	CDD:275368	9/22 (41%)
		C2H2 Zn finger	619..639	CDD:275368	8/19 (42%)
		zf-H2C2_2	635..656	CDD:404364	12/20 (60%)
		C2H2 Zn finger	647..667	CDD:275368	9/19 (47%)
		zf-H2C2_2	659..684	CDD:404364	13/24 (54%)
		C2H2 Zn finger	675..695	CDD:275368	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910