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Protein Alignment topi and ZNF891

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001264220.1	Gene:	ZNF891 / 101060200	HGNCID:	38709	Length:	544	Species:	Homo sapiens

Alignment Length:	665	Identity:	148/665 - (22%)
Similarity:	226/665 - (33%)	Gaps:	233/665 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SGEYTLAEIEV--ELDQQ------------LTPDD-LQPGATVLATNESTGGLERIVSHEELSRF 55
            |.||.|..:.|  .|||:            :.||. :||     .|.|||  :::|:..|
Human    81 SVEYQLYRLTVISPLDQEEIRNMKKRIPQAICPDQKIQP-----KTKEST--VQKILWEE----- 133

  Fly    56 FAVGPAGALPMPTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAG------VTSSK 114
                |:.|:.|     ::.|:.:  :...|:|       |.:..:::.:..:.|      :.:.|
Human   134 ----PSNAVKM-----IKLTMHN--WSSTLRE-------DWECHKIRKQHKIPGGHWRQMIYAPK 180

  Fly   115 MTTEQSVF---HGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPT 176
            .|..|.:|   |....||        |..:.|: |....|.:..|:....|:.
Human   181 KTVPQELFRDYHELEENS--------KLGSKLI-FSQSIFTSKHCQKCYSEIG------------ 224

  Fly   177 VSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHAS 241
                           .::.|.: :..|:|:.:...|....|               ||....|..
Human   225 ---------------CLKHNSI-INNYVKNSISEKLYESHE---------------CDTTLWHFQ 258

  Fly   242 GLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQ 306
                          .:||.::.:|....|:|                  |.|.:.....:..|.|
Human   259 --------------RNQTVQKEYTYSKHGMH------------------FTHNMFPVPNNLHMAQ 291

  Fly   307 SPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFAD 371
                    |..:.|:     :..:.:..:.....| |:..||.           :|..|...|..
Human   292 --------NACECNK-----DETLCHQSSLKKQGQ-THTEKKH-----------ECNQCGKAFKR 331

  Fly   372 IAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCEL 436
            |:.|.::..||:.|:::||..|....|.:.....|.:|.             |..:.:.||.|..
Human   332 ISNLTLYKKSHMGEKQYECKECGKVFNDSSTLRRHVRTH-------------TGEKPYECNQCGK 383

  Fly   437 KFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETR 501
            .|:....|:.|..|                                  |:.||
Human   384 AFSQKTSLKAHMRT----------------------------------HTGEK------------ 402

  Fly   502 NTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTG 566
                    .|.|:.||||:..||:|..|.|.|.|.|.:.|.|  |.:.|.....|..| :|.|||
Human   403 --------PYECNQCGKSFGTSSYLIVHKRIHTGEKLYECSE--CGKAFNTSSHLKVH-KKIHTG 456

  Fly   567 ERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFC 631
            |..|.|..|||.|...|....|...|.||:.|||:||.|.|..:.:|:.|.|||||||||.|:.|
Human   457 ENVYECSDCGKVFSGVSSLRMHIRTHTGEKPYECKECRKAFSVSSSLRRHVRIHTGEKPYECIQC 521

  Fly   632 TKTFRQRGDRDKHIR 646
            .|.|.|......|.|
Human   522 GKAFSQSSSLIIHKR 536

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.