DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and adprm.2

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_002935983.2	Gene:	adprm.2 / 100498212	XenbaseID:	XB-GENE-22063717	Length:	337	Species:	Xenopus tropicalis

Alignment Length:	294	Identity:	51/294 - (17%)
Similarity:	88/294 - (29%)	Gaps:	100/294 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 ADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPT 141
            ::.|.:::||..:|.||                           .:|....|.......|    :
Frog    84 SENALEKVLQVTEGMKG---------------------------RWHHVWGNHELYNFKR----S 117

  Fly   142 CLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKD 206
            .|||        .....:|:|..:|..|:.......:...:|..             |.|..:.|
Frog   118 YLVQ--------SKLNTRPMEDPIPDIERGEAADYYAYHFSPYP-------------RFRFVVID 161

  Fly   207 EMKYDLAT-GIESSRKN--------------AAKGPNECTMCDRKFVHASGLVRHMEKHALDLIP 256
              .|||:: |.:.:..|              ...|.::....:|:.|:.:|.|...:...|..|.
Frog   162 --TYDLSSLGRDMNHPNYQASIAFVTQSCSPEEPGDSKARKHERQLVNFNGGVGKEQLSWLHKIL 224

  Fly   257 SQTSEQPHTIPAAG---LHVVVKCNSCGRIFYDP--QVAFRHGLI-----------------HDS 299
            :...||...:..|.   :|...:..:|....|..  .|..||..:                 |..
Frog   225 TYADEQEEKVVIASHVPIHPNAQVTNCLAWNYSEILDVLHRHSCVVSYIAGHEHHGAYCQDSHGI 289

  Fly   300 EHSTMRQSPMTQVPSNRADF-------NELLLDG 326
            .|.||  ..:.:.|.|...|       |:::|.|
Frog   290 HHITM--EGVIESPPNTNAFATVHMYKNKMVLHG 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	5/38 (13%)
		C2H2 Zn finger	431..453	CDD:275368
		COG5048	<450..647	CDD:227381
		C2H2 Zn finger	469..490	CDD:275368
		zf-C2H2	511..533	CDD:278523
		C2H2 Zn finger	513..564	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368
		zf-H2C2_2	555..581	CDD:290200
		C2H2 Zn finger	572..592	CDD:275368
		zf-H2C2_2	585..609	CDD:290200
		zf-C2H2	598..620	CDD:278523
		C2H2 Zn finger	600..620	CDD:275368
		zf-H2C2_2	612..637	CDD:290200
		C2H2 Zn finger	628..646	CDD:275368
adprm.2	XP_002935983.2	MPP_Nbla03831	17..319	CDD:277341	49/290 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910