DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and ZNF717

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_011531546.1	Gene:	ZNF717 / 100131827	HGNCID:	29448	Length:	948	Species:	Homo sapiens

Alignment Length:	559	Identity:	138/559 - (24%)
Similarity:	202/559 - (36%)	Gaps:	145/559 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 NSSA---STVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPAS 189
            |:||   ..:.::..|||..:.|....|......||.|..  :.|||.
Human   281 NNSAVIVQVITQVGQPTCCRKSDFTKHQQTHTGEKPYECV--ECEKPS----------------- 326

  Fly   190 ERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDL 254
               |.::.:.|:..:..|.|                 |..|..|::.|.:.|.|:.|...|
Human   327 ---ISKSDLMLQCKMPTEEK-----------------PYACNWCEKLFSYKSSLIIHQRIH---- 367

  Fly   255 IPSQTSEQPHTIPAAG----------LH-------VVVKCNSCGRIFYDPQVAFRHGLIHDSEHS 302
                |.|:|:.....|          ||       ...||..||:.|:...:...|...|..|.
Human   368 ----TGEKPYGCNECGKTFRRKSFLTLHERTHTGDKPYKCIECGKTFHCKSLLTLHHRTHSGEK- 427

  Fly   303 TMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEY 367
                      |...::..:..        :..::.|.:..|:..:|.          ..|:.||.
Human   428 ----------PYQCSECGKTF--------SQKSYLTIHHRTHTGEKP----------YACDHCEE 464

  Fly   368 IFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCN 432
            .|:..:.|.||..:|..|:.:||..|...........:|.:|.             |..:.:.||
Human   465 AFSHKSRLTVHQRTHTGEKPYECNECGKPFINKSNLRLHQRTH-------------TGEKPYECN 516

  Fly   433 VCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLP--CDFCDVNFEFAHDFLAHSEEKHLNKKK 495
            .|...|.....|..|:.|         ..|:|   |  |:.|...|. ...||...:..|..:|
Human   517 ECGKTFHRKSFLTIHQWT---------HTGEK---PYECNECGKTFR-CKSFLTVHQRTHAGEK- 567

  Fly   496 REKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHI 560
                          .|.|:.|||:|:..|:|..|.|.|.|.||:.|.|  |.:.|..:..|..|
Human   568 --------------PYACNECGKTYSHKSYLTVHHRTHTGEKPYECNE--CGKSFHCKSFLTIH- 615

  Fly   561 RKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKP 625
            ::.|.|::||.|..|.|.|:.......|:..|.|||.|||.||||.|.:...|..||..||||||
Human   616 QRTHAGKKPYECNECEKTFINKLNLGIHKRTHTGERPYECNECGKTFRQKSNLSTHQGTHTGEKP 680

  Fly   626 YSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQK 664
            |.|..|.|||.::.....|.|   :|...|...:|.::|
Human   681 YVCNECGKTFHRKSFLTIHQR---THTGKNRMDVMNVEK 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	7/21 (33%)
		COG5048	<450..647	CDD:227381	68/198 (34%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	10/21 (48%)
		C2H2 Zn finger	513..564	CDD:275368	19/50 (38%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	10/25 (40%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	585..609	CDD:290200	13/23 (57%)
		zf-C2H2	598..620	CDD:278523	11/21 (52%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
ZNF717	XP_011531546.1	KRAB	56..116	CDD:214630
		KRAB	56..95	CDD:279668
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	343..723	CDD:227381	121/475 (25%)
		C2H2 Zn finger	347..367	CDD:275368	6/19 (32%)
		C2H2 Zn finger	375..395	CDD:275368	3/19 (16%)
		zf-H2C2_2	388..412	CDD:290200	7/23 (30%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		zf-H2C2_2	416..440	CDD:290200	4/42 (10%)
		zf-C2H2	429..451	CDD:278523	1/29 (3%)
		C2H2 Zn finger	431..451	CDD:275368	1/27 (4%)
		zf-H2C2_2	443..468	CDD:290200	7/34 (21%)
		C2H2 Zn finger	459..479	CDD:275368	7/19 (37%)
		zf-H2C2_2	472..494	CDD:290200	8/21 (38%)
		C2H2 Zn finger	487..507	CDD:275368	3/19 (16%)
		zf-H2C2_2	499..524	CDD:290200	7/37 (19%)
		C2H2 Zn finger	515..535	CDD:275368	7/28 (25%)
		zf-H2C2_2	528..552	CDD:290200	9/36 (25%)
		C2H2 Zn finger	543..563	CDD:275368	5/20 (25%)
		C2H2 Zn finger	571..591	CDD:275368	9/19 (47%)
		zf-H2C2_2	583..608	CDD:290200	11/26 (42%)
		COG5048	595..932	CDD:227381	50/128 (39%)
		C2H2 Zn finger	599..619	CDD:275368	6/22 (27%)
		C2H2 Zn finger	627..647	CDD:275368	5/19 (26%)
		zf-H2C2_2	639..664	CDD:290200	13/24 (54%)
		C2H2 Zn finger	655..675	CDD:275368	9/19 (47%)
		zf-H2C2_2	667..692	CDD:290200	15/24 (63%)
		C2H2 Zn finger	683..703	CDD:275368	7/22 (32%)
		zf-H2C2_2	779..801	CDD:290200
		C2H2 Zn finger	794..814	CDD:275368
		C2H2 Zn finger	822..842	CDD:275368
		zf-H2C2_2	835..859	CDD:290200
		C2H2 Zn finger	850..870	CDD:275368
		zf-H2C2_2	863..887	CDD:290200
		C2H2 Zn finger	878..898	CDD:275368
		zf-H2C2_2	891..913	CDD:290200
		zf-C2H2	904..926	CDD:278523
		C2H2 Zn finger	906..926	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910