DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8478 and ZNF142

DIOPT Version :9

Sequence 1:	NP_001163576.1	Gene:	CG8478 / 41194	FlyBaseID:	FBgn0037746	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	521	Identity:	94/521 - (18%)
Similarity:	154/521 - (29%)	Gaps:	154/521 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 VSLQEAAKTPAPSQVYPLSANVVLENITEVSNEGVSMLVSPAGAEKEVAHVN----EVVNEVSEL 243
            |.|::....|.|....||..  ||.. |:.|.:..|....||..|.|:....    |:..|..|.
Human  1091 VLLRKNKGLPRPDSPIPLQP--VLPG-TQASEDTESGKPPPASQEAELLLPKDAPLELPREPEET 1152

  Fly   244 IAKALKISADSVKPATSKLKVEAGKKRQSMSSTYSGAALP--RPRRSYL--------PTTTAETR 298
            ......:|...|.||.:.|..||.||........:|.:.|  .|::.:|        .:.|...:
Human  1153 EEPLATVSGSPVPPAGNSLPTEAPKKHCFDPVPPAGNSSPTEAPKKHHLDPVPPAGNSSPTEALK 1217

  Fly   299 TYSFKQ-------------RMSVVVKTTLNSPARKRSVGG--GVSLSRRSCLPVSKLTKSSIRKS 348
            .:.|:|             |:|.:...........|..||  |...::....|:|....:..:..
Human  1218 KHRFEQGKFHCNSCPFLCSRLSSITSHVAEGCRGGRGGGGKRGTPQTQPDVSPLSNGDSAPPKNG 1282

  Fly   349 LAVTSVRSPEKIASKPAKTSTKSIPEKVFSCKN------------------------CSTTFRVK 389
            ...:|....:.:..:..|.:..|.|...|||:.                        |..|....
Human  1283 STESSSGDGDTVLVQKQKGARFSCPTCPFSCQQERALRTHQIRGCPLEESGELHCSLCPFTAPAA 1347

  Fly   390 SLLDVHMRMHDPVDNGAN-------------TLK---------RLNSNPVAAGVSKNRCKFCD-- 430
            :.|.:|.:...|....|.             |.|         ||...    ||..::|.|||
Human  1348 TALRLHQKRRHPTAAPARGPRPHLQCGDCGFTCKQSRCMQQHRRLKHE----GVKPHQCPFCDFS 1408

  Fly   431 --------------------------KNFALERALHIHLMQNCDKIPPSEKRKLEFT-ELNHE-- 466
                                      :.|.....|.:|.::..||.|.......::: .|.|:
Human  1409 TTRRYRLEAHQSRHTGIGRIPCSSCPQTFGTNSKLRLHRLRVHDKTPTHFCPLCDYSGYLRHDIT 1473

  Fly   467 ---------------KKAQLPKIGGTSGINHPMTMPQKPQQRISTIPKLAPSQGTQSMAPPSVKK 516
                           .:.:......|:...|.:....:|.|         |:.|    :|....:
Human  1474 RHVNSCHQGTPAFACSQCEAQFSSETALKQHALRRHPEPAQ---------PAPG----SPAETTE 1525

  Fly   517 IPKNVAHAGVY-----------RTPTKTVPCHICKQSFRSILEFTNHSLTVHGNN--QLKKMTGR 568
            .|.:.:..|:.           |.....:.|..|:::|.|.|....|....|.::  ||.....|
Human  1526 GPLHCSRCGLLCPSPASLRGHTRKQHPRLECGACQEAFPSRLALDEHRRQQHFSHRCQLCDFAAR 1590

  Fly   569 E 569
            |
Human  1591 E 1591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8478	NP_001163576.1	zf-C2H2	377..399	CDD:278523	7/45 (16%)
		C2H2 Zn finger	379..399	CDD:275368	5/43 (12%)
		C2H2 Zn finger	426..444	CDD:275368	7/45 (16%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368
		C2H2 Zn finger	393..413	CDD:275368
		C2H2 Zn finger	421..438	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	545..566	CDD:275368
		C2H2 Zn finger	574..595	CDD:275368
		zf-H2C2_5	601..625	CDD:404746
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
		C2H2 Zn finger	714..731	CDD:275368
		PHA03247	928..>1219	CDD:223021	32/130 (25%)
		C2H2 Zn finger	1306..1353	CDD:275368	7/46 (15%)
		C2H2 Zn finger	1373..1394	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1402..1422	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1430..1451	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1626..1646	CDD:275368
		C2H2 Zn finger	1654..1674	CDD:275368
		C2H2 Zn finger	1682..1702	CDD:275368
		C2H2 Zn finger	1710..1730	CDD:275368
		zf-H2C2_2	1723..1747	CDD:404364
		C2H2 Zn finger	1738..1759	CDD:275368
		C2H2 Zn finger	1767..1787	CDD:275368
		C2H2 Zn finger	1795..1815	CDD:275368
		C2H2 Zn finger	1823..1843	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100