DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8478 and CG3281

DIOPT Version :9

Sequence 1:	NP_001163576.1	Gene:	CG8478 / 41194	FlyBaseID:	FBgn0037746	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	117/594 - (19%)
Similarity:	198/594 - (33%)	Gaps:	179/594 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LEVHNSKVEVNTDDK--DLRR---TILKDLHQLTIGEPDQNSPLR-------------PFDKSIL 106
            ||.|.:.:.|:.:.|  ||:.   .:|:.:.:|.....|.|.|:.             .|...:.
  Fly    19 LETHETNLYVHDEIKYNDLKLELWQLLEAVSKLKWTWTDPNLPMHLCQNCARRLIGAYEFIVEVE 83

  Fly   107 NRHNALCSTPSKGNISTETQTPQIMESIDLTQIDD-------------KENTQPEGCGGDNSTLS 158
            |.|..|.:...:..::.:.....: :.::|...||             :::.:.|...||....:
  Fly    84 NAHETLQNLFEQQEVAAKPDEVHV-DVVELIDQDDVVSMAQYLSTSFAEQHVEMEEKYGDQDCSA 147

  Fly   159 SSVDVTANTVKANTLKTGDATMDNVSLQEAAKTPAPSQVYPLSANVVLENITEVS---NEGVSML 220
            .:.||....:.|:. ...|...|:..|:     |.|.::    .|..|...:::.   |...:.:
  Fly   148 FTSDVGEEPLYASE-DRDDEPEDSFQLK-----PRPDEI----ENRELSRPSQLGSRLNHSANFI 202

  Fly   221 VSPAGAEKEVAHVNEVVNEVSELIAKALKISADSVKPATSKLKVEA-GK------------KRQS 272
            ...|...:..|....:....|:    |.|::||   .|..||..|: |.            |||.
  Fly   203 YKCAVCPRVFAKSESLTRHFSQ----AHKLTAD---VAAMKLANESCGTGLLTCEHCPRTFKRQD 260

  Fly   273 MSSTYSGAALPRPRRSYLPTTTAETRTYSFKQRMSVVVKTTLNSPARKRSVGGGVSLSRRSC--- 334
                    .|.|..:::.|...|            :..:.|.::.||||..      .||.|
  Fly   261 --------TLRRHMQAFHPDAIA------------LEPEETTDNSARKRIA------KRRDCPHC 299

  Fly   335 ---LPVSKLTKSSIRKSLAVTSVRSPEKIASKPAKTSTKSIPEKVFSCKNCSTTFRVKSLLDVHM 396
               .|||.|| ..||:...                       :..:.|..|...|.....|.:||
  Fly   300 GLSFPVSSLT-IHIRRHTG-----------------------DNPYKCDQCEKAFPRSQDLSLHM 340

  Fly   397 RMHD---PVDNGANTLKRLNSNPVA------AGVSKNRCKFCDKNFALERALHIHLMQNCDKIP- 451
            |.|.   |.:....:.|.::.|.:|      .|.....||.|.|:|.....|.||:.::..:.|
  Fly   341 RQHTGERPSECKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPY 405

  Fly   452 -----------PSEKRKLEFTELNHEKKAQLPKI--GGTSGIN---HPMTMPQKPQQRISTIPKL 500
                       .|.      ..::..:|..|..:  |.....|   .|....:..|:|...|.::
  Fly   406 QCGVCGESFVCGSH------LNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERM 464

  Fly   501 APSQGTQSMAPPSVKKIPKNVAHAGVYRTPTKTVP-----CHICKQSFRSILEFTNHSLTVHGNN 560
                        .:::||:|.....:...|...||     |.:|:|.|:|     ...||||.|
  Fly   465 ------------RLQRIPENQLQQRLENLPKPDVPAMCYKCGVCEQKFKS-----GALLTVHRN- 511

  Fly   561 QLKKMTGRE 569
               ||:..|
  Fly   512 ---KMSHYE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8478	NP_001163576.1	zf-C2H2	377..399	CDD:278523	7/21 (33%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..444	CDD:275368	8/17 (47%)
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	16/72 (22%)
		C2H2 Zn finger	205..226	CDD:275368	3/24 (13%)
		C2H2 Zn finger	249..266	CDD:275368	5/24 (21%)
		COG5048	<294..>391	CDD:227381	27/120 (23%)
		C2H2 Zn finger	296..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	307..330	CDD:290200	6/46 (13%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..358	CDD:290200	6/22 (27%)
		C2H2 Zn finger	351..371	CDD:275368	3/19 (16%)
		zf-H2C2_2	364..388	CDD:290200	7/23 (30%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		zf-H2C2_2	391..416	CDD:290200	4/24 (17%)
		C2H2 Zn finger	407..424	CDD:275368	1/22 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100