DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8478 and CG6791

DIOPT Version :9

Sequence 1:	NP_001163576.1	Gene:	CG8478 / 41194	FlyBaseID:	FBgn0037746	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster

Alignment Length:	691	Identity:	125/691 - (18%)
Similarity:	208/691 - (30%)	Gaps:	233/691 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DTLSNAKWQSALVTQNSQFLEVHNSKVEVNTDDKDLRRTILKDLHQLTIGEPDQNSPLRPFDKSI 105
            |..::|:|     :|:.:|:..:.|:..:|....|::...|:....:|   |:....||....|.
  Fly   360 DCDTHAQW-----SQHIEFVHDYVSRRGLNFRSVDMQMQCLECKKIVT---PNTIKSLRAHKFSH 416

  Fly   106 LNRHNAL-CSTPSKGNISTETQTPQIMES--IDLTQIDDKENTQPEG-------CGGDNSTLSSS 160
            |::...| |....||....:.....:::.  :|....:|.|....:.       |.|||
  Fly   417 LSQPEWLRCKLCYKGYTDHQEIIRHLLQQHHMDTLMSEDAEEEDGDAPSAIEDECDGDN------ 475

  Fly   161 VDVTANTVKANTLKTGDATMDNVSLQEAAK--TPAPSQVYPLSANVVLENITEVSNEGVSMLVSP 223
                           |:...:...|.|.:.  ..||.:...:|::.:.|       ..:..|...
  Fly   476 ---------------GNGEGNGAPLDEDSPYFEDAPRRGGRISSDDIFE-------PHIDYLCPQ 518

  Fly   224 AGAE-KEVAHVNEVVNEVSELIAKALKISADSVKPATSKLKVEAGKKRQ--------SMSSTYSG 279
            .|.| .|..|....|            :.|.|:.. .|||..|...:||        .:::.|..
  Fly   519 CGKEFIEKKHWRTHV------------VMAHSMND-LSKLNFEMINERQLKCTECDKIITNAYGI 570

  Fly   280 AALPRPRRSYLP-TTTAETRT--YSFKQRMSVVVK-TTLNSPARKRSVGGGVSLSRRSCLPVSKL 340
            ....:.|.::|| ...|..|.  .|:..|..:|.. .|.:.....|.:.||       | |...|
  Fly   571 QNAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSGG-------C-PAPIL 627

  Fly   341 TKSSIRKSLAVT------------------------------------SVRSPEKIASKPAKTST 369
            |.:...:...||                                    .:..|......|.:.:|
  Fly   628 TPAKQPRKQIVTVANETYEIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIAPPPPSPPPPPQPTT 692

  Fly   370 KSIPEKVFSCKNCSTTFRVKSLLDVHM-----------RMHDPVDNGANTLKRLNSNPVAAGVSK 423
            :...:: :.|.:|.|.|..::.:.||:           |...||.:.|        :|....|.:
  Fly   693 QGNHQR-YKCVHCGTLFATQAAVRVHISEKRCRKTVVRRRRQPVMSSA--------DPSVPTVEQ 748

  Fly   424 N---RCKFCDKNF--ALERALHIHLMQNCDKIPPSEKRKLE------------------------ 459
            |   .|..|...:  ..|...||:.:.|.||......|:|:
  Fly   749 NYIFLCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLKGLQDH 813

  Fly   460 -FTEL---------------NHEKKAQLPKIGGTSGINHPM------TMPQKPQQRISTI----- 497
             |..|               ||:     |.|.......|.:      ||..||:|.:...
  Fly   814 HFRHLPYRLYLKCLICGTCYNHK-----PNIAAHLRARHSIFDRETPTMITKPKQVLGRYKDNSR 873

  Fly   498 --PKL--APSQGTQSMAPPSVKKIPKNVAHAGVYRT--------PTK------------------ 532
              |||  .|.....:.||||......:.|.:...|:        |.:
  Fly   874 ENPKLPSPPPAPALAPAPPSPPACSSSAAASASSRSLKPQPGGLPARPAGLNTLEDSISYHNAVD 938

  Fly   533 ----TVPCHICKQSFRSILEFTNHSLTVHGNNQLKKMTGRE 569
                |..|..|.|:|.|...:..|.:..|..|..:.:..|:
  Fly   939 LDFITYFCPKCNQNFDSHAFWRKHIVEQHNFNSREGLNFRQ 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8478	NP_001163576.1	zf-C2H2	377..399	CDD:278523	7/32 (22%)
		C2H2 Zn finger	379..399	CDD:275368	7/30 (23%)
		C2H2 Zn finger	426..444	CDD:275368	5/19 (26%)
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368
		C2H2 Zn finger	208..230	CDD:275368
		C2H2 Zn finger	235..256	CDD:275368
		C2H2 Zn finger	516..532	CDD:275368	4/15 (27%)
		C2H2 Zn finger	557..580	CDD:275368	2/22 (9%)
		C2H2 Zn finger	589..609	CDD:275368	4/19 (21%)
		COG5236	<939..>1096	CDD:227561	10/41 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100