DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8478 and CG2678

DIOPT Version :9

Sequence 1:	NP_001163576.1	Gene:	CG8478 / 41194	FlyBaseID:	FBgn0037746	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_649750.1	Gene:	CG2678 / 40937	FlyBaseID:	FBgn0014931	Length:	434	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	85/453 - (18%)
Similarity:	160/453 - (35%)	Gaps:	120/453 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 CGGDNSTLSSSVDVTANTVKANTLKTGDATMDNVSLQEAAKTPAP-----SQVYPLSANVVLENI 209
            |..:..||   ||:.|| |:...|...:.::.:: |....:.|..     .|...:|..:.::|.
  Fly    12 CMDETGTL---VDIFAN-VRDPVLDEPEMSLSHI-LARCTERPVKRGDLLPQFICVSCVLAVQNA 71

  Fly   210 ------TEVSNEGVSMLVSPAGAEKEVAHVNEVVNEVSELIAKALKISADSVKPATSKLKVEAG- 267
                  :|.|.:....:::.:||.:...|:.....:.:::|.:.:::.:|..:......|.:..
  Fly    72 FRFKWQSEQSYQHFFRVLNQSGAPENQVHLAACNGDKNQIINQKMQLKSDRQQDTQQMTKTQKPD 136

  Fly   268 ---KKRQSMSSTYSGAALPRPRRSYLPTTTAETRTYSFKQRMSVVVKTTLNSPARKRSVGGGVS- 328
               .::|::.:......:..|..|:  |.....||...:::..::.|....|........|..:
  Fly   137 DDLSQKQTLQAKLQEGNIDGPPESF--TLHPRKRTCRTEEQADMIPKEATRSTKMICDADGYYNC 199

  Fly   329 --LSRRSC------------------LPVSKLTKSSIRKSLAVTSVRSPEKIASKPAKTSTKSIP 373
              .|:|.|                  .|.:.:.||::::.|        ....||||
  Fly   200 PHCSKRFCSQTQLRTHITDLCNRCPYCPRTYMQKSNLKRHL--------RNHLSKPA-------- 248

  Fly   374 EKVFSCKNCSTTFRVKSLLDVHMRMHDPVDNGANTLKRLNSNPVAAGVSKNRCKFCDKNFALERA 438
               ..|.:||..|..|..|..|:|.||            :..|::       |..|...|.....
  Fly   249 ---HKCFHCSKAFMRKDHLKRHLRTHD------------SDGPLS-------CSQCSAVFIEHVQ 291

  Fly   439 LHIHLMQNCDKIPPSEKRKLEFTELNHEKKAQLPKIGGTSGINHPMTMPQKPQQRISTIPKLAPS 503
            |.||..::..:...|:....:..:.:...:||                ..||:...:|.
  Fly   292 LEIHRREHKQRPGSSKSESTKDPDSDDSDQAQ----------------DLKPKWTKNTF------ 334

  Fly   504 QGTQSMAPPSVKKIPKNVAHAGVYRTPTKTVPCHICKQSFRSILEFTNHSLTVHGNNQLKKMT 566
            .||.|: ||.:|  ||.:              |.||::.|.|:.....|.||.:..:.|||.|
  Fly   335 NGTCSI-PPMLK--PKPI--------------CDICQKKFSSVYALKRHMLTHNRQHHLKKCT 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8478	NP_001163576.1	zf-C2H2	377..399	CDD:278523	8/21 (38%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..444	CDD:275368	6/17 (35%)
CG2678	NP_649750.1	zf-AD	8..85	CDD:214871	16/77 (21%)
		COG5048	220..>284	CDD:227381	21/101 (21%)
		C2H2 Zn finger	223..243	CDD:275368	4/27 (15%)
		zf-C2H2	249..271	CDD:278523	8/21 (38%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	1/2 (50%)
		C2H2 Zn finger	406..427	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100